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Title: Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers

Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. Lastly, CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.
Authors:
 [1] ;  [2] ;  [2] ;  [2] ;  [3] ;  [3] ;  [4] ;  [5] ;  [5] ;  [3] ;  [2] ;  [2] ;  [2] ;  [6] ;  [2] ;  [3] ;  [2] ;  [2] ;  [7] ;  [5] more »;  [5] ;  [5] ;  [4] ;  [3] ;  [5] ;  [7] ;  [3] ;  [3] ;  [2] « less
  1. The Univ. of Texas MD Anderson Cancer Center (MDACC), Houston, TX (United States); Chiba Univ., Chiba (Japan)
  2. The Univ. of Texas MD Anderson Cancer Center (MDACC), Houston, TX (United States)
  3. MDACC, Houston, TX (United States)
  4. Univ. of Puerto Rico-Mayaguez, Mayaguez (Puerto Rico)
  5. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  6. The Univ. of Texas MD Anderson Cancer Center (MDACC), Houston, TX (United States); Hokkaido Univ. Graduate School of Medicine, Sapporo (Japan)
  7. Catholic Univ. of the Sacred Heart, Rome (Italy)
Publication Date:
Report Number(s):
PNNL-SA-120868
Journal ID: ISSN 2211-1247; 48666; 453040220
Grant/Contract Number:
AC05-76RL01830
Type:
Accepted Manuscript
Journal Name:
Cell Reports
Additional Journal Information:
Journal Volume: 17; Journal Issue: 6; Journal ID: ISSN 2211-1247
Publisher:
Elsevier
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Environmental Molecular Sciences Laboratory; hyperthermia; ovarian cancer; CTGF; DOPC-liposome; thermosensitivity; copper sulfide nanoparticle
OSTI Identifier:
1339834