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Title: LUNGx Challenge for computerized lung nodule classification

The purpose of this work is to describe the LUNGx Challenge for the computerized classification of lung nodules on diagnostic computed tomography (CT) scans as benign or malignant and report the performance of participants’ computerized methods along with that of six radiologists who participated in an observer study performing the same Challenge task on the same dataset. The Challenge provided sets of calibration and testing scans, established a performance assessment process, and created an infrastructure for case dissemination and result submission. We present ten groups that applied their own methods to 73 lung nodules (37 benign and 36 malignant) that were selected to achieve approximate size matching between the two cohorts. Area under the receiver operating characteristic curve (AUC) values for these methods ranged from 0.50 to 0.68; only three methods performed statistically better than random guessing. The radiologists’ AUC values ranged from 0.70 to 0.85; three radiologists performed statistically better than the best-performing computer method. The LUNGx Challenge compared the performance of computerized methods in the task of differentiating benign from malignant lung nodules on CT scans, placed in the context of the performance of radiologists on the same task. Lastly, the continued public availability of the Challenge casesmore » will provide a valuable resource for the medical imaging research community.« less
Authors:
 [1] ;  [1] ;  [1] ;  [2] ;  [3] ;  [1] ;  [1] ;  [4] ;  [4] ;  [5] ;  [4]
  1. Univ. of Chicago, IL (United States). Department of Radiology
  2. Univ. of Michigan, Ann Arbor, MI (United States). Department of Radiology
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Health Data Sciences Institute, Biomedical Science and Engineering Center
  4. National Cancer Institute, Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, Bethesda, MD (United States)
  5. Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Cancer Imaging Program, Frederick, MD (United States)
Publication Date:
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Journal of Medical Imaging
Additional Journal Information:
Journal Volume: 3; Journal Issue: 4; Journal ID: ISSN 2329-4302
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 97 MATHEMATICS AND COMPUTING
OSTI Identifier:
1338539