Shock Wave-Induced Damage of a Protein by Void Collapse

Lau, Edmond Y.; Berkowitz, Max L.; Schwegler, Eric

doi:10.1016/j.bpj.2015.11.030

Title: Shock Wave-Induced Damage of a Protein by Void Collapse

Abstract

In this study, we report on a series of molecular dynamics simulations that were used to examine the effects of shockwaves on a membrane bound ion channel. A planar shockwave was found to compress the ion channel upon impact but the protein geometry resembles the initial structure as soon as the solvent density begins to dissipate. When a void was placed in close proximity to the membrane, the shockwave proved to be much more destructive to the protein due to formation of a nanojet that results from the asymmetric collapse of the void. The nanojet was able to cause significant structural changes to the protein even at low particle velocities that are not able to directly cause poration of the membrane.

Authors:: Lau, Edmond Y.; Berkowitz, Max L.; Schwegler, Eric

Publication Date:: Fri Jan 01 00:00:00 EST 2016

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1338259

Alternate Identifier(s):: OSTI ID: 1241952; OSTI ID: 1325274

Report Number(s):: LLNL-JRNL-671538
Journal ID: ISSN 0006-3495; S0006349515012138; PII: S0006349515012138

Grant/Contract Number:: AC52-07NA27344

Resource Type:: Published Article

Journal Name:: Biophysical Journal

Additional Journal Information:: Journal Name: Biophysical Journal Journal Volume: 110 Journal Issue: 1; Journal ID: ISSN 0006-3495

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Lau, Edmond Y., Berkowitz, Max L., and Schwegler, Eric. Shock Wave-Induced Damage of a Protein by Void Collapse.  United States: N. p., 2016. 
Web.  doi:10.1016/j.bpj.2015.11.030.

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                    Lau, Edmond Y., Berkowitz, Max L., & Schwegler, Eric. Shock Wave-Induced Damage of a Protein by Void Collapse.  United States.  https://doi.org/10.1016/j.bpj.2015.11.030

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                    Lau, Edmond Y., Berkowitz, Max L., and Schwegler, Eric. Fri .  
"Shock Wave-Induced Damage of a Protein by Void Collapse".  United States.  https://doi.org/10.1016/j.bpj.2015.11.030.

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@article{osti_1338259,

  title        = {Shock Wave-Induced Damage of a Protein by Void Collapse},

  author       = {Lau, Edmond Y. and Berkowitz, Max L. and Schwegler, Eric},

  abstractNote = {In this study, we report on a series of molecular dynamics simulations that were used to examine the effects of shockwaves on a membrane bound ion channel. A planar shockwave was found to compress the ion channel upon impact but the protein geometry resembles the initial structure as soon as the solvent density begins to dissipate. When a void was placed in close proximity to the membrane, the shockwave proved to be much more destructive to the protein due to formation of a nanojet that results from the asymmetric collapse of the void. The nanojet was able to cause significant structural changes to the protein even at low particle velocities that are not able to directly cause poration of the membrane.},

  doi          = {10.1016/j.bpj.2015.11.030},

  journal      = {Biophysical Journal},

  number       = 1,

  volume       = 110,

  place        = {United States},

  year         = {Fri Jan 01 00:00:00 EST 2016},

  month        = {Fri Jan 01 00:00:00 EST 2016}

}

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Nanobubbles, cavitation, shock waves and traumatic brain injury
journal, January 2016

Adhikari, Upendra; Goliaei, Ardeshir; Berkowitz, Max L.
Physical Chemistry Chemical Physics, Vol. 18, Issue 48
DOI: 10.1039/c6cp06704b

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