skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

Authors:
; ; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1337464
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Published Article
Journal Name:
PLoS ONE
Additional Journal Information:
Journal Name: PLoS ONE Journal Volume: 11 Journal Issue: 8; Journal ID: ISSN 1932-6203
Publisher:
Public Library of Science (PLoS)
Country of Publication:
United States
Language:
English

Citation Formats

Waight, Andrew B., Bargsten, Katja, Doronina, Svetlana, Steinmetz, Michel O., Sussman, Django, Prota, Andrea E., and Komarova, ed., Yulia. Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics. United States: N. p., 2016. Web. doi:10.1371/journal.pone.0160890.
Waight, Andrew B., Bargsten, Katja, Doronina, Svetlana, Steinmetz, Michel O., Sussman, Django, Prota, Andrea E., & Komarova, ed., Yulia. Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics. United States. doi:10.1371/journal.pone.0160890.
Waight, Andrew B., Bargsten, Katja, Doronina, Svetlana, Steinmetz, Michel O., Sussman, Django, Prota, Andrea E., and Komarova, ed., Yulia. Fri . "Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics". United States. doi:10.1371/journal.pone.0160890.
@article{osti_1337464,
title = {Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics},
author = {Waight, Andrew B. and Bargsten, Katja and Doronina, Svetlana and Steinmetz, Michel O. and Sussman, Django and Prota, Andrea E. and Komarova, ed., Yulia},
abstractNote = {},
doi = {10.1371/journal.pone.0160890},
journal = {PLoS ONE},
number = 8,
volume = 11,
place = {United States},
year = {2016},
month = {8}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1371/journal.pone.0160890

Citation Metrics:
Cited by: 8 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications
journal, December 2014

  • Maderna, Andreas; Doroski, Matthew; Subramanyam, Chakrapani
  • Journal of Medicinal Chemistry, Vol. 57, Issue 24
  • DOI: 10.1021/jm501649k

Structural basis for the regulation of tubulin by vinblastine
journal, May 2005

  • Gigant, Benoît; Wang, Chunguang; Ravelli, Raimond B. G.
  • Nature, Vol. 435, Issue 7041
  • DOI: 10.1038/nature03566

cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity
journal, August 2003


Dolastatin 10, a powerful cytostatic peptide derived from a marine animal
journal, June 1990


Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules
journal, December 2015

  • Wang, Yuxi; Benz, Frederick W.; Wu, Yangping
  • Molecular Pharmacology, Vol. 89, Issue 2
  • DOI: 10.1124/mol.115.100149

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
journal, January 2013


Microtubules as a target for anticancer drugs
journal, April 2004

  • Jordan, Mary Ann; Wilson, Leslie
  • Nature Reviews Cancer, Vol. 4, Issue 4
  • DOI: 10.1038/nrc1317

Variations in the colchicine-binding domain provide insight into the structural switch of tubulin
journal, August 2009

  • Dorleans, A.; Gigant, B.; Ravelli, R. B. G.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 33
  • DOI: 10.1073/pnas.0904223106

Dynamic instability of microtubule growth
journal, November 1984

  • Mitchison, Tim; Kirschner, Marc
  • Nature, Vol. 312, Issue 5991
  • DOI: 10.1038/312237a0

Development of potent monoclonal antibody auristatin conjugates for cancer therapy
journal, June 2003

  • Doronina, Svetlana O.; Toki, Brian E.; Torgov, Michael Y.
  • Nature Biotechnology, Vol. 21, Issue 7
  • DOI: 10.1038/nbt832

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate
journal, November 2008


A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end
journal, July 2012

  • Pecqueur, Ludovic; Duellberg, Christian; Dreier, Birgit
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 30
  • DOI: 10.1073/pnas.1204129109

Enhanced Activity of Monomethylauristatin F through Monoclonal Antibody Delivery:  Effects of Linker Technology on Efficacy and Toxicity
journal, January 2006

  • Doronina, Svetlana O.; Mendelsohn, Brian A.; Bovee, Tim D.
  • Bioconjugate Chemistry, Vol. 17, Issue 1
  • DOI: 10.1021/bc0502917

The binding conformation of Taxol in  -tubulin: A model based on electron crystallographic density
journal, April 2001

  • Snyder, J. P.; Nettles, J. H.; Cornett, B.
  • Proceedings of the National Academy of Sciences, Vol. 98, Issue 9
  • DOI: 10.1073/pnas.051309398

Structural plasticity of tubulin assembly probed by vinca-domain ligands
journal, July 2012

  • Ranaivoson, Fanomezana M.; Gigant, Benoît; Berritt, Simon
  • Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 8
  • DOI: 10.1107/S0907444912017143

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
journal, May 2014


Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins
journal, August 2015


The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin
journal, September 2011

  • Nawrotek, Agata; Knossow, Marcel; Gigant, Benoît
  • Journal of Molecular Biology, Vol. 412, Issue 1
  • DOI: 10.1016/j.jmb.2011.07.029

Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A
journal, January 2014

  • Prota, Andrea E.; Bargsten, Katja; Northcote, Peter T.
  • Angewandte Chemie International Edition, Vol. 53, Issue 6
  • DOI: 10.1002/anie.201307749

Mitosis is not a key target of microtubule agents in patient tumors
journal, February 2011

  • Komlodi-Pasztor, Edina; Sackett, Dan; Wilkerson, Julia
  • Nature Reviews Clinical Oncology, Vol. 8, Issue 4
  • DOI: 10.1038/nrclinonc.2010.228

Structural insight into the inhibition of tubulin by vinca domain peptide ligands
journal, September 2008

  • Cormier, Anthony; Marchand, Matthieu; Ravelli, Raimond B. G.
  • EMBO reports, Vol. 9, Issue 11
  • DOI: 10.1038/embor.2008.171

Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.
journal, October 1992

  • Hyman, A. A.; Salser, S.; Drechsel, D. N.
  • Molecular Biology of the Cell, Vol. 3, Issue 10
  • DOI: 10.1091/mbc.3.10.1155

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization
journal, April 2014

  • Prota, Andrea E.; Danel, Franck; Bachmann, Felix
  • Journal of Molecular Biology, Vol. 426, Issue 8
  • DOI: 10.1016/j.jmb.2014.02.005

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
journal, August 2014

  • Prota, A. E.; Bargsten, K.; Diaz, J. F.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 38
  • DOI: 10.1073/pnas.1408124111

Structural basis of tubulin tyrosination by tubulin tyrosine ligase
journal, January 2013

  • Prota, Andrea E.; Magiera, Maria M.; Kuijpers, Marijn
  • The Journal of Cell Biology, Vol. 200, Issue 3
  • DOI: 10.1083/jcb.201211017

Microtubule Polymerization Dynamics
journal, November 1997


Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
journal, March 2004

  • Ravelli, Raimond B. G.; Gigant, Benoît; Curmi, Patrick A.
  • Nature, Vol. 428, Issue 6979
  • DOI: 10.1038/nature02393