Lipid metabolic changes in an early divergent fungus govern the establishment of a mutualistic symbiosis with endobacteria
Abstract
Significance Mutually beneficial interactions of fungi with bacteria are increasingly recognized as ubiquitous and economically important. However, little is known about their establishment and maintenance. Utilizing the association between the fungus Rhizopus microsporus and its endosymbiont Burkholderia as a model, we provide first insights into fungal molecular mechanisms governing symbiosis establishment with bacteria. We show that specific changes in fungal lipid metabolism, mediated by diacylgycerol kinase enzymes, are required to maintain a mutualistic outcome of interaction with bacteria, a pattern consistent with the addiction model of mutualism evolution. We also offer insights into genetics and biochemistry of lipid metabolism in an understudied group of oleaginous fungi, which are a promising source of oils for biodiesel production.
- Authors:
-
[2];
- Graduate Field of Microbiology, Cornell University, Ithaca, NY 14853,
- Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853,
- US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598,
- School of Integrative Plant Science, Plant Pathology and Plant-Microbe Biology, Cornell University, Ithaca, NY 14853
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1335527
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Published Article
- Journal Name:
- Proceedings of the National Academy of Sciences of the United States of America
- Additional Journal Information:
- Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Volume: 113 Journal Issue: 52; Journal ID: ISSN 0027-8424
- Publisher:
- Proceedings of the National Academy of Sciences
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Lastovetsky, Olga A., Gaspar, Maria L., Mondo, Stephen J., LaButti, Kurt M., Sandor, Laura, Grigoriev, Igor V., Henry, Susan A., and Pawlowska, Teresa E. Lipid metabolic changes in an early divergent fungus govern the establishment of a mutualistic symbiosis with endobacteria. United States: N. p., 2016.
Web. doi:10.1073/pnas.1615148113.
Lastovetsky, Olga A., Gaspar, Maria L., Mondo, Stephen J., LaButti, Kurt M., Sandor, Laura, Grigoriev, Igor V., Henry, Susan A., & Pawlowska, Teresa E. Lipid metabolic changes in an early divergent fungus govern the establishment of a mutualistic symbiosis with endobacteria. United States. https://doi.org/10.1073/pnas.1615148113
Lastovetsky, Olga A., Gaspar, Maria L., Mondo, Stephen J., LaButti, Kurt M., Sandor, Laura, Grigoriev, Igor V., Henry, Susan A., and Pawlowska, Teresa E. Mon .
"Lipid metabolic changes in an early divergent fungus govern the establishment of a mutualistic symbiosis with endobacteria". United States. https://doi.org/10.1073/pnas.1615148113.
@article{osti_1335527,
title = {Lipid metabolic changes in an early divergent fungus govern the establishment of a mutualistic symbiosis with endobacteria},
author = {Lastovetsky, Olga A. and Gaspar, Maria L. and Mondo, Stephen J. and LaButti, Kurt M. and Sandor, Laura and Grigoriev, Igor V. and Henry, Susan A. and Pawlowska, Teresa E.},
abstractNote = {Significance Mutually beneficial interactions of fungi with bacteria are increasingly recognized as ubiquitous and economically important. However, little is known about their establishment and maintenance. Utilizing the association between the fungus Rhizopus microsporus and its endosymbiont Burkholderia as a model, we provide first insights into fungal molecular mechanisms governing symbiosis establishment with bacteria. We show that specific changes in fungal lipid metabolism, mediated by diacylgycerol kinase enzymes, are required to maintain a mutualistic outcome of interaction with bacteria, a pattern consistent with the addiction model of mutualism evolution. We also offer insights into genetics and biochemistry of lipid metabolism in an understudied group of oleaginous fungi, which are a promising source of oils for biodiesel production.},
doi = {10.1073/pnas.1615148113},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 52,
volume = 113,
place = {United States},
year = {Mon Dec 12 00:00:00 EST 2016},
month = {Mon Dec 12 00:00:00 EST 2016}
}
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https://doi.org/10.1073/pnas.1615148113
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