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Title: Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles

Amphiphilic Janus particles self-assemble into complex metastructures, but little is known about how their assembly might be modified by weak interactions with a nearby biological membrane surface. Here, we report an integrated experimental and molecular dynamics simulation study to investigate the self-assembly of amphiphilic Janus particles on a lipid membrane. We created an experimental system in which Janus particles are allowed to self-assemble in the same medium where zwitterionic lipids form giant unilamellar vesicles (GUVs). Janus particles spontaneously concentrated on the inner leaflet of the GUVs. They exhibited biased orientation and heterogeneous rotational dynamics as revealed by single particle rotational tracking. The combined experimental and simulation results show that Janus particles concentrate on the lipid membranes due to weak particle–lipid attraction, whereas the biased orientation of particles is driven predominantly by inter-particle interactions. Furthermore, this study demonstrates the potential of using lipid membranes to influence the self-assembly of Janus particles.
Authors:
 [1] ;  [2] ;  [1] ;  [1] ;  [3] ;  [1] ;  [2] ;  [1]
  1. Indiana Univ., Bloomington, IN (United States)
  2. Columbia Univ., Broadway, NY (United States)
  3. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Report Number(s):
SAND-2016-12074J
Journal ID: ISSN 1744-683X; SMOABF; 649523
Grant/Contract Number:
AC04-94AL85000
Type:
Accepted Manuscript
Journal Name:
Soft Matter
Additional Journal Information:
Journal Volume: 12; Journal Issue: 45; Journal ID: ISSN 1744-683X
Publisher:
Royal Society of Chemistry
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES
OSTI Identifier:
1334497

Chambers, Mariah, Mallory, Stewart Anthony, Malone, Heather, Gao, Yuan, Anthony, Stephen M., Yi, Yi, Cacciuto, Angelo, and Yu, Yan. Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles. United States: N. p., Web. doi:10.1039/c6sm02171a.
Chambers, Mariah, Mallory, Stewart Anthony, Malone, Heather, Gao, Yuan, Anthony, Stephen M., Yi, Yi, Cacciuto, Angelo, & Yu, Yan. Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles. United States. doi:10.1039/c6sm02171a.
Chambers, Mariah, Mallory, Stewart Anthony, Malone, Heather, Gao, Yuan, Anthony, Stephen M., Yi, Yi, Cacciuto, Angelo, and Yu, Yan. 2016. "Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles". United States. doi:10.1039/c6sm02171a. https://www.osti.gov/servlets/purl/1334497.
@article{osti_1334497,
title = {Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles},
author = {Chambers, Mariah and Mallory, Stewart Anthony and Malone, Heather and Gao, Yuan and Anthony, Stephen M. and Yi, Yi and Cacciuto, Angelo and Yu, Yan},
abstractNote = {Amphiphilic Janus particles self-assemble into complex metastructures, but little is known about how their assembly might be modified by weak interactions with a nearby biological membrane surface. Here, we report an integrated experimental and molecular dynamics simulation study to investigate the self-assembly of amphiphilic Janus particles on a lipid membrane. We created an experimental system in which Janus particles are allowed to self-assemble in the same medium where zwitterionic lipids form giant unilamellar vesicles (GUVs). Janus particles spontaneously concentrated on the inner leaflet of the GUVs. They exhibited biased orientation and heterogeneous rotational dynamics as revealed by single particle rotational tracking. The combined experimental and simulation results show that Janus particles concentrate on the lipid membranes due to weak particle–lipid attraction, whereas the biased orientation of particles is driven predominantly by inter-particle interactions. Furthermore, this study demonstrates the potential of using lipid membranes to influence the self-assembly of Janus particles.},
doi = {10.1039/c6sm02171a},
journal = {Soft Matter},
number = 45,
volume = 12,
place = {United States},
year = {2016},
month = {1}
}