5-Fluoroimidazo[4,5- b ]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

Zhang, Zhongsheng; Koh, Cho Yeow; Ranade, Ranae M.; Shibata, Sayaka; Gillespie, J. Robert; Hulverson, Matthew A.; Huang, Wenlin; Nguyen, Jasmine; Pendem, Nagendar; Gelb, Michael H.; Verlinde, Christophe L. M. J.; Hol, Wim G. J.; Buckner, Frederick S.; Fan, Erkang

doi:10.1021/acsinfecdis.6b00036

Title: 5-Fluoroimidazo[4,5- b ]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

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Authors:

Zhang, Zhongsheng ^[1]; Koh, Cho Yeow ^[1]; Ranade, Ranae M. ^[2]; Shibata, Sayaka ^[1]; Gillespie, J. Robert ^[2]; Hulverson, Matthew A. ^[2]; Huang, Wenlin ^[1]; Nguyen, Jasmine ^[1]; Pendem, Nagendar ^[3]; Gelb, Michael H. ^[3]; Verlinde, Christophe L. M. J. ^[1]; Hol, Wim G. J. ^[1]; Buckner, Frederick S. ^[2]; Fan, Erkang ^[1]

Department of Biochemistry, University of Washington, 1705 N.E. Pacific Street, Seattle, Washington 98195, United States
Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States
Department of Chemistry, Bagley Hall, University of Washington, Seattle, Washington 98195, United States

Publication Date:: Mon Apr 11 00:00:00 EDT 2016

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:: 1331717

Grant/Contract Number:: AC02-76SF00515

Resource Type:: Published Article

Journal Name:: ACS Infectious Diseases

Additional Journal Information:: Journal Name: ACS Infectious Diseases Journal Volume: 2 Journal Issue: 6; Journal ID: ISSN 2373-8227

Publisher:: American Chemical Society

Country of Publication:: United States

Language:: English

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                    Zhang, Zhongsheng, Koh, Cho Yeow, Ranade, Ranae M., Shibata, Sayaka, Gillespie, J. Robert, Hulverson, Matthew A., Huang, Wenlin, Nguyen, Jasmine, Pendem, Nagendar, Gelb, Michael H., Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., and Fan, Erkang. 5-Fluoroimidazo[4,5- b ]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.  United States: N. p., 2016. 
Web.  doi:10.1021/acsinfecdis.6b00036.

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                    Zhang, Zhongsheng, Koh, Cho Yeow, Ranade, Ranae M., Shibata, Sayaka, Gillespie, J. Robert, Hulverson, Matthew A., Huang, Wenlin, Nguyen, Jasmine, Pendem, Nagendar, Gelb, Michael H., Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., & Fan, Erkang. 5-Fluoroimidazo[4,5- b ]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.  United States.  https://doi.org/10.1021/acsinfecdis.6b00036

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                    Zhang, Zhongsheng, Koh, Cho Yeow, Ranade, Ranae M., Shibata, Sayaka, Gillespie, J. Robert, Hulverson, Matthew A., Huang, Wenlin, Nguyen, Jasmine, Pendem, Nagendar, Gelb, Michael H., Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., and Fan, Erkang. Mon .  
"5-Fluoroimidazo[4,5- b ]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors".  United States.  https://doi.org/10.1021/acsinfecdis.6b00036.

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@article{osti_1331717,

  title        = {5-Fluoroimidazo[4,5- b ]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors},

  author       = {Zhang, Zhongsheng and Koh, Cho Yeow and Ranade, Ranae M. and Shibata, Sayaka and Gillespie, J. Robert and Hulverson, Matthew A. and Huang, Wenlin and Nguyen, Jasmine and Pendem, Nagendar and Gelb, Michael H. and Verlinde, Christophe L. M. J. and Hol, Wim G. J. and Buckner, Frederick S. and Fan, Erkang},

  abstractNote = {},

  doi          = {10.1021/acsinfecdis.6b00036},

  journal      = {ACS Infectious Diseases},

  number       = 6,

  volume       = 2,

  place        = {United States},

  year         = {Mon Apr 11 00:00:00 EDT 2016},

  month        = {Mon Apr 11 00:00:00 EDT 2016}

}

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