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Title: Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma

Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain poor. In addition, advances in next-generation sequencing provide a route to therapeutic approaches, and integrating DNA and RNA analysis with clinicopathologic data may be a crucial step toward personalized treatment strategies for this disease.
Authors:
 [1] ;  [2] ;  [2] ;  [2] ;  [2] ;  [3] ;  [3] ;  [2] ;  [2] ;  [2] ;  [2] ;  [2] ;  [2] ;  [4] ;  [4] ;  [4] ;  [4] ;  [4] ;  [5] ;  [6] more »;  [7] ;  [8] ;  [9] ;  [9] ;  [10] ;  [11] ;  [12] ;  [9] ;  [13] ;  [2] ;  [2] ;  [14] ;  [2] ;  [15] ;  [10] ;  [16] ;  [17] ;  [2] ;  [18] ;  [1] « less
  1. Ontario Institute for Cancer Research, Toronto, ON (Canada); Mount Sinai Hospital, Toronto, ON (Canada); Univ. Health Network, Toronto, ON (Canada)
  2. Ontario Institute for Cancer Research, Toronto, ON (Canada)
  3. Mount Sinai Hospital, Toronto, ON (Canada)
  4. The Univ. of Liverpool, Liverpool (United Kingdom)
  5. Heidelberg University Hospital, Heidelberg (Germany)
  6. Mayo Clinic, Rochester, MN (United States)
  7. Massachusetts General Hospital, Boston, MA (United States)
  8. Univ. of Nebraska Medical Centre, Omaha, NE (United States)
  9. Mount Sinai Hospital, Toronto, ON (Canada); Univ. of Toronto, Toronto, ON (Canada)
  10. Princess Margaret Cancer Centre, Toronto, ON (Canada)
  11. Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
  12. Univ. Health Network, Toronto, ON (Canada)
  13. Ontario Institute for Cancer Research, Toronto, ON (Canada); Univ. Health Network, Toronto, ON (Canada); Univ. of Toronto, Toronto, ON (Canada)
  14. Ontario Institute for Cancer Research, Toronto, ON (Canada); Univ. Health Network, Toronto, ON (Canada)
  15. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  16. Univ. of Toronto, Toronto, ON (Canada)
  17. Genome Technologies Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada17Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
  18. Ontario Institute for Cancer Research, Toronto, ON (Canada); Univ. of Toronto, Toronto, ON (Canada)
Publication Date:
Report Number(s):
LA-UR-16-20982
Journal ID: ISSN 2374-2437
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
JAMA Oncology
Additional Journal Information:
Journal Name: JAMA Oncology; Journal ID: ISSN 2374-2437
Publisher:
American Medical Association
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE Laboratory Directed Research and Development (LDRD) Program
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Biological Science
OSTI Identifier:
1331271

Connor, Ashton A., Denroche, Robert E., Jang, Gun Ho, Timms, Lee, Kalimuthu, Sangeetha N., Selander, Iris, McPherson, Treasa, Wilson, Gavin W., Chan-Seng-Yue, Michelle A., Borozan, Ivan, Ferretti, Vincent, Grant, Robert C., Lungu, Ilinca M., Costello, Eithne, Greenhalf, William, Palmer, Daniel, Ghaneh, Paula, Neoptolemos, John P., Buchler, Markus, Petersen, Gloria, Thayer, Sarah, Hollingsworth, Michael A., Sherker, Alana, Durocher, Daniel, Dhani, Neesha, Hedley, David, Serra, Stefano, Pollett, Aaron, Roehrl, Michael H. A., Bavi, Prashant, Bartlett, John M. S., Cleary, Sean, Wilson, Julie M., Alexandrov, Ludmil B., Moore, Malcolm, Wouters, Bradly G., McPherson, John D., Notta, Faiyaz, Stein, Lincoln D., and Gallinger, Steven. Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma. United States: N. p., Web. doi:10.1001/jamaoncol.2016.3916.
Connor, Ashton A., Denroche, Robert E., Jang, Gun Ho, Timms, Lee, Kalimuthu, Sangeetha N., Selander, Iris, McPherson, Treasa, Wilson, Gavin W., Chan-Seng-Yue, Michelle A., Borozan, Ivan, Ferretti, Vincent, Grant, Robert C., Lungu, Ilinca M., Costello, Eithne, Greenhalf, William, Palmer, Daniel, Ghaneh, Paula, Neoptolemos, John P., Buchler, Markus, Petersen, Gloria, Thayer, Sarah, Hollingsworth, Michael A., Sherker, Alana, Durocher, Daniel, Dhani, Neesha, Hedley, David, Serra, Stefano, Pollett, Aaron, Roehrl, Michael H. A., Bavi, Prashant, Bartlett, John M. S., Cleary, Sean, Wilson, Julie M., Alexandrov, Ludmil B., Moore, Malcolm, Wouters, Bradly G., McPherson, John D., Notta, Faiyaz, Stein, Lincoln D., & Gallinger, Steven. Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma. United States. doi:10.1001/jamaoncol.2016.3916.
Connor, Ashton A., Denroche, Robert E., Jang, Gun Ho, Timms, Lee, Kalimuthu, Sangeetha N., Selander, Iris, McPherson, Treasa, Wilson, Gavin W., Chan-Seng-Yue, Michelle A., Borozan, Ivan, Ferretti, Vincent, Grant, Robert C., Lungu, Ilinca M., Costello, Eithne, Greenhalf, William, Palmer, Daniel, Ghaneh, Paula, Neoptolemos, John P., Buchler, Markus, Petersen, Gloria, Thayer, Sarah, Hollingsworth, Michael A., Sherker, Alana, Durocher, Daniel, Dhani, Neesha, Hedley, David, Serra, Stefano, Pollett, Aaron, Roehrl, Michael H. A., Bavi, Prashant, Bartlett, John M. S., Cleary, Sean, Wilson, Julie M., Alexandrov, Ludmil B., Moore, Malcolm, Wouters, Bradly G., McPherson, John D., Notta, Faiyaz, Stein, Lincoln D., and Gallinger, Steven. 2016. "Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma". United States. doi:10.1001/jamaoncol.2016.3916. https://www.osti.gov/servlets/purl/1331271.
@article{osti_1331271,
title = {Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma},
author = {Connor, Ashton A. and Denroche, Robert E. and Jang, Gun Ho and Timms, Lee and Kalimuthu, Sangeetha N. and Selander, Iris and McPherson, Treasa and Wilson, Gavin W. and Chan-Seng-Yue, Michelle A. and Borozan, Ivan and Ferretti, Vincent and Grant, Robert C. and Lungu, Ilinca M. and Costello, Eithne and Greenhalf, William and Palmer, Daniel and Ghaneh, Paula and Neoptolemos, John P. and Buchler, Markus and Petersen, Gloria and Thayer, Sarah and Hollingsworth, Michael A. and Sherker, Alana and Durocher, Daniel and Dhani, Neesha and Hedley, David and Serra, Stefano and Pollett, Aaron and Roehrl, Michael H. A. and Bavi, Prashant and Bartlett, John M. S. and Cleary, Sean and Wilson, Julie M. and Alexandrov, Ludmil B. and Moore, Malcolm and Wouters, Bradly G. and McPherson, John D. and Notta, Faiyaz and Stein, Lincoln D. and Gallinger, Steven},
abstractNote = {Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain poor. In addition, advances in next-generation sequencing provide a route to therapeutic approaches, and integrating DNA and RNA analysis with clinicopathologic data may be a crucial step toward personalized treatment strategies for this disease.},
doi = {10.1001/jamaoncol.2016.3916},
journal = {JAMA Oncology},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {10}
}