Transcriptional control of Sost in bone

Sebastian, Aimy; Loots, Gabriela G.

doi:10.1016/j.bone.2016.10.009

Title: Transcriptional control of Sost in bone

Abstract

Sclerostin is an osteocyte derived negative regulator of bone formation. A highly specific expression pattern and the exclusive bone phenotype have made Sclerostin an attractive target for therapeutic intervention in treating metabolic bone diseases such as osteoporosis and in facilitating fracture repair. Understanding the molecular mechanisms that regulate Sclerostin transcription is of great interest as it may unveil new avenues for therapeutic approaches. Such studies may also elucidate how various signaling pathways intersect to modulate bone metabolism. Furthermore we review the current understanding of the upstream molecular mechanisms that regulate Sost/SOST transcription, in bone.

Authors:: Sebastian, Aimy; Loots, Gabriela G.

Publication Date:: Wed Mar 01 00:00:00 EST 2017

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1330597

Alternate Identifier(s):: OSTI ID: 1347664

Report Number(s):: LLNL-JRNL-691682
Journal ID: ISSN 8756-3282; S875632821630299X; PII: S875632821630299X

Grant/Contract Number:: 16-ERD-007; AC52-07NA27344

Resource Type:: Published Article

Journal Name:: Bone

Additional Journal Information:: Journal Name: Bone Journal Volume: 96 Journal Issue: C; Journal ID: ISSN 8756-3282

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Sebastian, Aimy, and Loots, Gabriela G. Transcriptional control of Sost in bone.  United States: N. p., 2017. 
Web.  doi:10.1016/j.bone.2016.10.009.

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                    Sebastian, Aimy, & Loots, Gabriela G. Transcriptional control of Sost in bone.  United States.  https://doi.org/10.1016/j.bone.2016.10.009

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                    Sebastian, Aimy, and Loots, Gabriela G. Wed .  
"Transcriptional control of Sost in bone".  United States.  https://doi.org/10.1016/j.bone.2016.10.009.

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@article{osti_1330597,

  title        = {Transcriptional control of Sost in bone},

  author       = {Sebastian, Aimy and Loots, Gabriela G.},

  abstractNote = {Sclerostin is an osteocyte derived negative regulator of bone formation. A highly specific expression pattern and the exclusive bone phenotype have made Sclerostin an attractive target for therapeutic intervention in treating metabolic bone diseases such as osteoporosis and in facilitating fracture repair. Understanding the molecular mechanisms that regulate Sclerostin transcription is of great interest as it may unveil new avenues for therapeutic approaches. Such studies may also elucidate how various signaling pathways intersect to modulate bone metabolism. Furthermore we review the current understanding of the upstream molecular mechanisms that regulate Sost/SOST transcription, in bone.},

  doi          = {10.1016/j.bone.2016.10.009},

  journal      = {Bone},

  number       = C,

  volume       = 96,

  place        = {United States},

  year         = {Wed Mar 01 00:00:00 EST 2017},

  month        = {Wed Mar 01 00:00:00 EST 2017}

}

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Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice
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Title: Transcriptional control of Sost in bone

Abstract

Citation Formats

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journal, May 2019

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