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Title: In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel

Abstract

Here, we present a simple microfluidic technique to in-situ photopolymerize (by 365 nm ultraviolet) monodisperse oxidized methacrylated alginate (OMA) microgels using a photoinitiator (VA-086). By this technique, we generated monodisperse spherical OMA beads and discoid non-spherical beads with better shape consistency than ionic crosslinking methods do. We found that a high monomer concentration (8 w/v %), a high photoinitiator concentration (1.5 w/v %) and absence of oxygen are critical factors to cure OMA microgels. This photopolymerizing method is an alternative to current methods to form alginate microgels and is a simpler approach to generate non-spherical alginate microgels.

Authors:
 [1];  [2];  [3];  [1];  [2];  [3]; ORCiD logo [1];  [1]
  1. Michigan Technological Univ., Houghton, MI (United States)
  2. Case Western Reserve Univ., Cleveland, OH (United States)
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1327751
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Biomicrofluidics
Additional Journal Information:
Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 1932-1058
Publisher:
American Institute of Physics (AIP)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 36 MATERIALS SCIENCE; microgels; fluid drops; ultraviolet light; polymers; microscale flows

Citation Formats

Wang, Shuo, Jeon, Oju, Shankles, Peter G., Liu, Yuan, Alsberg, Eben, Retterer, Scott T., Lee, Bruce P., and Choi, Chang Kyoung. In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel. United States: N. p., 2016. Web. doi:10.1063/1.4941339.
Wang, Shuo, Jeon, Oju, Shankles, Peter G., Liu, Yuan, Alsberg, Eben, Retterer, Scott T., Lee, Bruce P., & Choi, Chang Kyoung. In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel. United States. doi:10.1063/1.4941339.
Wang, Shuo, Jeon, Oju, Shankles, Peter G., Liu, Yuan, Alsberg, Eben, Retterer, Scott T., Lee, Bruce P., and Choi, Chang Kyoung. Wed . "In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel". United States. doi:10.1063/1.4941339. https://www.osti.gov/servlets/purl/1327751.
@article{osti_1327751,
title = {In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel},
author = {Wang, Shuo and Jeon, Oju and Shankles, Peter G. and Liu, Yuan and Alsberg, Eben and Retterer, Scott T. and Lee, Bruce P. and Choi, Chang Kyoung},
abstractNote = {Here, we present a simple microfluidic technique to in-situ photopolymerize (by 365 nm ultraviolet) monodisperse oxidized methacrylated alginate (OMA) microgels using a photoinitiator (VA-086). By this technique, we generated monodisperse spherical OMA beads and discoid non-spherical beads with better shape consistency than ionic crosslinking methods do. We found that a high monomer concentration (8 w/v %), a high photoinitiator concentration (1.5 w/v %) and absence of oxygen are critical factors to cure OMA microgels. This photopolymerizing method is an alternative to current methods to form alginate microgels and is a simpler approach to generate non-spherical alginate microgels.},
doi = {10.1063/1.4941339},
journal = {Biomicrofluidics},
number = 1,
volume = 10,
place = {United States},
year = {2016},
month = {2}
}

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