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Title: Strain and bioprocess improvement of a thermophilic anaerobe for the production of ethanol from wood

Here, the thermophilic, anaerobic bacterium Thermoanaerobacterium saccharolyticum digests hemicellulose and utilizes the major sugars present in biomass. It was previously engineered to produce ethanol at yields equivalent to yeast. While saccharolytic anaerobes have been long studied as potential biomass-fermenting organisms, development efforts for commercial ethanol production have not been reported.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7] ;  [3] ;  [4] ;  [4] ;  [4] ;  [4] ;  [4] ;  [8] ;  [9] ;  [9] ;  [9] ;  [10] ;  [11]
  1. Mascoma Corp., Lebanon, NH (United States); Dartmouth College, Hanover, NH (United States)
  2. Mascoma Corp., Lebanon, NH (United States); Verdezyne, Carlsbad, CA (United States)
  3. Mascoma Corp., Lebanon, NH (United States); Novogy, Inc., Cambridge, MA (United States)
  4. Mascoma Corp., Lebanon, NH (United States)
  5. Dartmouth College, Hanover, NH (United States); Bioenergy Science Center, Oak Ridge, TN (United States)
  6. Mascoma Corp., Lebanon, NH (United States); Genzyme, Cambridge, MA (United States)
  7. Mascoma Corp., Lebanon, NH (United States); Myriant Corp., Quincy, MA (United States)
  8. Mascoma Corp., Lebanon, NH (United States); Nalco Champion, Houston, TX (United States)
  9. Bioenergy Science Center, Oak Ridge, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  10. Mascoma Corp., Lebanon, NH (United States); Dartmouth College, Hanover, NH (United States); Bioenergy Science Center, Oak Ridge, TN (United States)
  11. Mascoma Corp., Lebanon, NH (United States); Novozymes, Inc., Davis, CA (United States)
Publication Date:
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Biotechnology for Biofuels
Additional Journal Information:
Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 1754-6834
Publisher:
BioMed Central
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). BioEnergy Science Center (BESC)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS; cellulosic ethanol; consolidated bioprocessing; organism development; metabolic engineering; bioprocess development; Thermophilic bacteria
OSTI Identifier:
1327705