Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy
Abstract
We present that targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as 223Ra, 225Ra, and 225Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during their decay. Utilizing appropriate carriers capable of retaining both the parent radioisotope as well as daughter products is important for the effective delivery of the radioisotope to the tumor site while mitigating global in vivo radiotoxicity. In this article, LaPO4 core and core + 2 shells nanoparticles (NPs) (NPs with 2 layers of cold LaPO4 deposited on the core surfaces) were synthesized containing either 223Ra or 225Ra/225Ac, and the retention of the parents and daughters within the NPs in vitro was investigated.
- Authors:
-
[2]
- Missouri Univ. of Science and Technology, Rolla, MO (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Provision Center for Biomedical Research, Knoxville, TN (United States)
- Missouri Univ. of Science and Technology, Rolla, MO (United States)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
- Sponsoring Org.:
- USDOE Office of Science (SC), Nuclear Physics (NP); USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1185834
- Alternate Identifier(s):
- OSTI ID: 1327625; OSTI ID: 1359708
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nuclear Medicine and Biology
- Additional Journal Information:
- Journal Volume: 42; Journal Issue: 7; Journal ID: ISSN 0969-8051
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; Targeted alpha Therapy; Actinium-225; Radium-223; Radium-225; Lanthanum Phosphate; 60 APPLIED LIFE SCIENCES; Targeted alpha therapy; Targeted radioimmunotherapy; Radioactive nanoparticles; Lanthanum phosphate; in-vitro retention; in-vivo generators
Citation Formats
Rojas, J. V., Woodward, J. D., Chen, N., Rondinone, A. J., Castano, C. H., and Mirzadeh, S. Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy. United States: N. p., 2015.
Web. doi:10.1016/j.nucmedbio.2015.03.007.
Rojas, J. V., Woodward, J. D., Chen, N., Rondinone, A. J., Castano, C. H., & Mirzadeh, S. Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy. United States. https://doi.org/10.1016/j.nucmedbio.2015.03.007
Rojas, J. V., Woodward, J. D., Chen, N., Rondinone, A. J., Castano, C. H., and Mirzadeh, S. Thu .
"Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy". United States. https://doi.org/10.1016/j.nucmedbio.2015.03.007. https://www.osti.gov/servlets/purl/1185834.
@article{osti_1185834,
title = {Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy},
author = {Rojas, J. V. and Woodward, J. D. and Chen, N. and Rondinone, A. J. and Castano, C. H. and Mirzadeh, S.},
abstractNote = {We present that targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as 223Ra, 225Ra, and 225Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during their decay. Utilizing appropriate carriers capable of retaining both the parent radioisotope as well as daughter products is important for the effective delivery of the radioisotope to the tumor site while mitigating global in vivo radiotoxicity. In this article, LaPO4 core and core + 2 shells nanoparticles (NPs) (NPs with 2 layers of cold LaPO4 deposited on the core surfaces) were synthesized containing either 223Ra or 225Ra/225Ac, and the retention of the parents and daughters within the NPs in vitro was investigated.},
doi = {10.1016/j.nucmedbio.2015.03.007},
journal = {Nuclear Medicine and Biology},
number = 7,
volume = 42,
place = {United States},
year = {Thu Mar 19 00:00:00 EDT 2015},
month = {Thu Mar 19 00:00:00 EDT 2015}
}
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