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Title: Local phase separation of co-solvents enhances pretreatment of biomass for bioenergy applications

Abstract

Pretreatment facilitates more complete deconstruction of plant biomass to enable more economic production of lignocellulosic biofuels and byproducts. Various co-solvent pretreatments have demonstrated advantages relative to aqueous-only methods by enhancing lignin removal to allow unfettered access to cellulose. However, there is a limited mechanistic understanding of the interactions between the co-solvents and cellulose that impedes further improvement of such pretreatment methods. Recently, tetrahydrofuran (THF) has been identified as a highly effective co-solvent for the pretreatment and fractionation of biomass. Here, to elucidate the mechanism of the THF water interactions with cellulose, we pair simulation and experimental data demonstrating that enhanced solubilization of cellulose can be achieved by the THF water co-solvent system at equivolume mixtures and moderate temperatures (≤445 K). The simulations show that THF and water spontaneously phase separate on the local surface of a cellulose fiber, owing to hydrogen bonding of water molecules with the hydrophilic cellulose faces and stacking of THF molecules on the hydrophobic faces. Furthermore, a single fully solvated cellulose chain is shown to be preferentially bound by water molecules in the THF water mixture. In light of these findings, co-solvent reactions were performed on microcrystalline cellulose and maple wood to show that THF significantlymore » enhanced cellulose deconstruction and lignocellulose solubilization at simulation conditions, enabling a highly versatile and efficient biomass pretreatment and fractionation method.« less

Authors:
 [1];  [2];  [3];  [3];  [3];  [2];  [3]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of California, Riverside, CA (United States)
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); The Univ. of Tennessee, Knoxville, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). BioEnergy Science Center (BESC)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1326557
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Journal of the American Chemical Society
Additional Journal Information:
Journal Volume: 138; Journal Issue: 34; Journal ID: ISSN 0002-7863
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS

Citation Formats

Mostofian, Barmak, Cai, Charles M., Smith, Micholas Dean, Petridis, Loukas, Cheng, Xiaolin, Wyman, Charles E., and Smith, Jeremy C.. Local phase separation of co-solvents enhances pretreatment of biomass for bioenergy applications. United States: N. p., 2016. Web. https://doi.org/10.1021/jacs.6b03285.
Mostofian, Barmak, Cai, Charles M., Smith, Micholas Dean, Petridis, Loukas, Cheng, Xiaolin, Wyman, Charles E., & Smith, Jeremy C.. Local phase separation of co-solvents enhances pretreatment of biomass for bioenergy applications. United States. https://doi.org/10.1021/jacs.6b03285
Mostofian, Barmak, Cai, Charles M., Smith, Micholas Dean, Petridis, Loukas, Cheng, Xiaolin, Wyman, Charles E., and Smith, Jeremy C.. Tue . "Local phase separation of co-solvents enhances pretreatment of biomass for bioenergy applications". United States. https://doi.org/10.1021/jacs.6b03285. https://www.osti.gov/servlets/purl/1326557.
@article{osti_1326557,
title = {Local phase separation of co-solvents enhances pretreatment of biomass for bioenergy applications},
author = {Mostofian, Barmak and Cai, Charles M. and Smith, Micholas Dean and Petridis, Loukas and Cheng, Xiaolin and Wyman, Charles E. and Smith, Jeremy C.},
abstractNote = {Pretreatment facilitates more complete deconstruction of plant biomass to enable more economic production of lignocellulosic biofuels and byproducts. Various co-solvent pretreatments have demonstrated advantages relative to aqueous-only methods by enhancing lignin removal to allow unfettered access to cellulose. However, there is a limited mechanistic understanding of the interactions between the co-solvents and cellulose that impedes further improvement of such pretreatment methods. Recently, tetrahydrofuran (THF) has been identified as a highly effective co-solvent for the pretreatment and fractionation of biomass. Here, to elucidate the mechanism of the THF water interactions with cellulose, we pair simulation and experimental data demonstrating that enhanced solubilization of cellulose can be achieved by the THF water co-solvent system at equivolume mixtures and moderate temperatures (≤445 K). The simulations show that THF and water spontaneously phase separate on the local surface of a cellulose fiber, owing to hydrogen bonding of water molecules with the hydrophilic cellulose faces and stacking of THF molecules on the hydrophobic faces. Furthermore, a single fully solvated cellulose chain is shown to be preferentially bound by water molecules in the THF water mixture. In light of these findings, co-solvent reactions were performed on microcrystalline cellulose and maple wood to show that THF significantly enhanced cellulose deconstruction and lignocellulose solubilization at simulation conditions, enabling a highly versatile and efficient biomass pretreatment and fractionation method.},
doi = {10.1021/jacs.6b03285},
journal = {Journal of the American Chemical Society},
number = 34,
volume = 138,
place = {United States},
year = {2016},
month = {8}
}

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