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Title: pH-Controlled Assembly of DNA Tiles

We demonstrate a strategy to trigger and finely control the assembly of supramolecular DNA nanostructures with pH. Control is achieved via a rationally designed strand displacement circuit that responds to pH and activates a downstream DNA tile self-assembly process. We observe that the DNA structures form under neutral/basic conditions, while the self-assembly process is suppressed under acidic conditions. The strategy presented here demonstrates a modular approach toward building systems capable of processing biochemical inputs and finely controlling the assembly of DNA-based nanostructures under isothermal conditions. In particular, the presented architecture is relevant for the development of complex DNA devices able to sense and respond to molecular markers associated with abnormal metabolism.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [1]
  1. Univ. of Rome Tor Vergata (Italy)
  2. Univ. of Trieste (Italy); Univ. of Udine (Italy)
  3. Univ. of Trieste (Italy); Univ. of Udine (Italy); Univ. of Leeds (United Kingdom)
  4. Univ. of California, Riverside, CA (United States)
Publication Date:
Grant/Contract Number:
SC0010595
Type:
Published Article
Journal Name:
Journal of the American Chemical Society
Additional Journal Information:
Journal Volume: 138; Journal Issue: 39; Journal ID: ISSN 0002-7863
Publisher:
American Chemical Society (ACS)
Research Org:
Univ. of California, Riverside, CA (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 36 MATERIALS SCIENCE
OSTI Identifier:
1326110
Alternate Identifier(s):
OSTI ID: 1329029