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Title: Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain

Abstract

The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. Here we mapped the posterior projections of the human AF in the inferior parietal and lateral temporal cortices using surface-based structural connectivity analysis based on diffusion MRI and investigated their hemispheric differences. We then performed the cross-modal comparison with functional connectivity based on resting-state functional MRI (fMRI) and task-related cortical activation based on fMRI using a semantic classification task of single words. Structural connectivity analysis showed that the left AF connecting to Broca's area predominantly projected in the lateral temporal cortex extending from the posterior superior temporal gyrus to the mid part of the superior temporal sulcus and the middle temporal gyrus, whereas the right AF connecting to the right homolog of Broca's area predominantly projected to the inferior parietal cortex extending from the mid part of the supramarginal gyrus to the anterior part of the angular gyrus. The left-lateralized projection regions of the AF in the left temporal cortex had asymmetric functional connectivity with Broca's area, indicating structure-function concordance through the AF. During the language task, left-lateralizedmore » cortical activation was observed. Among them, the brain responses in the temporal cortex and Broca's area that were connected through the left-lateralized AF pathway were specifically correlated across subjects. These results suggest that the human left AF, which structurally and functionally connects the mid temporal cortex and Broca's area in asymmetrical fashion, coordinates the cortical activity in these remote cortices during a semantic decision task. As a result, the unique feature of the left AF is discussed in the context of the human capacity for language.« less

Authors:
 [1];  [1];  [2];  [1];  [1];  [1];  [1];  [2]
  1. Massachusetts General Hospital and Harvard Medical School, Charlestown, MA (United States)
  2. (United States)
Publication Date:
Research Org.:
Massachusetts General Hospital, Charlestown, MA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1324974
Grant/Contract Number:  
SC0008430
Resource Type:
Accepted Manuscript
Journal Name:
Frontiers in Neuroanatomy
Additional Journal Information:
Journal Volume: 9; Journal ID: ISSN 1662-5129
Publisher:
Frontiers Research Foundation
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; language pathway; cortical projection; structure-function; surface-based; structural connectivity; functional connectivity; MRI; semantic decision

Citation Formats

Takaya, Shigetoshi, Kuperberg, Gina R., Tufts Univ., Medford, MA, Liu, Hesheng, Greve, Douglas N., Makris, Nikos, Stufflebeam, Steven M., and Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA. Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain. United States: N. p., 2015. Web. doi:10.3389/fnana.2015.00119.
Takaya, Shigetoshi, Kuperberg, Gina R., Tufts Univ., Medford, MA, Liu, Hesheng, Greve, Douglas N., Makris, Nikos, Stufflebeam, Steven M., & Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA. Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain. United States. doi:10.3389/fnana.2015.00119.
Takaya, Shigetoshi, Kuperberg, Gina R., Tufts Univ., Medford, MA, Liu, Hesheng, Greve, Douglas N., Makris, Nikos, Stufflebeam, Steven M., and Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA. Tue . "Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain". United States. doi:10.3389/fnana.2015.00119. https://www.osti.gov/servlets/purl/1324974.
@article{osti_1324974,
title = {Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain},
author = {Takaya, Shigetoshi and Kuperberg, Gina R. and Tufts Univ., Medford, MA and Liu, Hesheng and Greve, Douglas N. and Makris, Nikos and Stufflebeam, Steven M. and Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA},
abstractNote = {The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. Here we mapped the posterior projections of the human AF in the inferior parietal and lateral temporal cortices using surface-based structural connectivity analysis based on diffusion MRI and investigated their hemispheric differences. We then performed the cross-modal comparison with functional connectivity based on resting-state functional MRI (fMRI) and task-related cortical activation based on fMRI using a semantic classification task of single words. Structural connectivity analysis showed that the left AF connecting to Broca's area predominantly projected in the lateral temporal cortex extending from the posterior superior temporal gyrus to the mid part of the superior temporal sulcus and the middle temporal gyrus, whereas the right AF connecting to the right homolog of Broca's area predominantly projected to the inferior parietal cortex extending from the mid part of the supramarginal gyrus to the anterior part of the angular gyrus. The left-lateralized projection regions of the AF in the left temporal cortex had asymmetric functional connectivity with Broca's area, indicating structure-function concordance through the AF. During the language task, left-lateralized cortical activation was observed. Among them, the brain responses in the temporal cortex and Broca's area that were connected through the left-lateralized AF pathway were specifically correlated across subjects. These results suggest that the human left AF, which structurally and functionally connects the mid temporal cortex and Broca's area in asymmetrical fashion, coordinates the cortical activity in these remote cortices during a semantic decision task. As a result, the unique feature of the left AF is discussed in the context of the human capacity for language.},
doi = {10.3389/fnana.2015.00119},
journal = {Frontiers in Neuroanatomy},
number = ,
volume = 9,
place = {United States},
year = {2015},
month = {9}
}

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