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Title: Cholesterol's location in lipid bilayers

It is well known that cholesterol modifies the physical properties of lipid bilayers. For example, the much studied liquid-ordered L o phase contains rapidly diffusing lipids with their acyl chains in the all trans configuration, similar to gel phase bilayers. Moreover, the L o phase is commonly associated with cholesterol-enriched lipid rafts, which are thought to serve as platforms for signaling proteins in the plasma membrane. Cholesterol's location in lipid bilayers has been studied extensively, and it has been shown – at least in some bilayers – to align differently from its canonical upright orientation, where its hydroxyl group is in the vicinity of the lipid–water interface. In this study we review recent works describing cholesterol's location in different model membrane systems with emphasis on results obtained from scattering, spectroscopic and molecular dynamics studies.
 [1] ;  [2] ;  [3] ;  [4] ;  [5]
  1. Univ. of Graz, Graz (Austria); BioTechMed-Graz (Austria)
  2. Joint Institute for Nuclear Research, Dubna (Moscow); Comenius Univ., Bratislava (Slovakia)
  3. Indiana Univ. Purdue Univ. Indianapolis, Indianapolis, IN (United States)
  4. Brock Univ., St. Catharines, ON (Canada)
  5. Brock Univ., St. Catharines, ON (Canada); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Joint Institute for Neutron Sciences, Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
Publication Date:
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Chemistry and Physics of Lipids
Additional Journal Information:
Journal Volume: 199; Journal Issue: C; Journal ID: ISSN 0009-3084
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; biomembranes; cholesterol; neutron scattering; sterol; membrane dynamics; membrane structure; lipid domains
OSTI Identifier:
Alternate Identifier(s):
OSTI ID: 1396442