Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice
Abstract
To improve our understanding of the stability of mammalian intestinal communities, we characterized the responses of both bacterial and viral communities in murine fecal samples to dietary changes between high- and low-fat (LF) diets. Targeted DNA extraction methods for bacteria, virus-like particles and induced prophages were used to generate bacterial and viral metagenomes as well as 16S ribosomal RNA amplicons. Gut microbiome communities from two cohorts of C57BL/6 mice were characterized in a 6-week diet perturbation study in response to high fiber, LF and high-refined sugar, milkfat (MF) diets. The resulting metagenomes from induced bacterial prophages and extracellular viruses showed significant overlap, supporting a largely temperate viral lifestyle within these gut microbiomes. The resistance of baseline communities to dietary disturbances was evaluated, and we observed contrasting responses of baseline LF and MF bacterial and viral communities. In contrast to baseline LF viral communities and bacterial communities in both diet treatments, baseline MF viral communities were sensitive to dietary disturbances as reflected in their non-recovery during the washout period. Finally, the contrasting responses of bacterial and viral communities suggest that these communities can respond to perturbations independently of each other and highlight the potentially unique role of viruses in gut health.
- Authors:
-
- Iowa State Univ., Ames, IA (United States); Argonne National Lab. (ANL), Argonne, IL (United States)
- Univ. of Chicago, Chicago, IL (United States)
- Iowa State Univ., Ames, IA (United States)
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, Chicago, IL (United States)
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1315658
- Grant/Contract Number:
- AC02-06CH11357
- Resource Type:
- Accepted Manuscript
- Journal Name:
- The ISME Journal
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 5; Journal ID: ISSN 1751-7362
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Howe, Adina, Ringus, Daina L., Williams, Ryan J., Choo, Zi -Ning, Greenwald, Stephanie M., Owens, Sarah M., Coleman, Maureen L., Meyer, Folker, and Chang, Eugene B. Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice. United States: N. p., 2015.
Web. doi:10.1038/ismej.2015.183.
Howe, Adina, Ringus, Daina L., Williams, Ryan J., Choo, Zi -Ning, Greenwald, Stephanie M., Owens, Sarah M., Coleman, Maureen L., Meyer, Folker, & Chang, Eugene B. Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice. United States. https://doi.org/10.1038/ismej.2015.183
Howe, Adina, Ringus, Daina L., Williams, Ryan J., Choo, Zi -Ning, Greenwald, Stephanie M., Owens, Sarah M., Coleman, Maureen L., Meyer, Folker, and Chang, Eugene B. Fri .
"Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice". United States. https://doi.org/10.1038/ismej.2015.183. https://www.osti.gov/servlets/purl/1315658.
@article{osti_1315658,
title = {Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice},
author = {Howe, Adina and Ringus, Daina L. and Williams, Ryan J. and Choo, Zi -Ning and Greenwald, Stephanie M. and Owens, Sarah M. and Coleman, Maureen L. and Meyer, Folker and Chang, Eugene B.},
abstractNote = {To improve our understanding of the stability of mammalian intestinal communities, we characterized the responses of both bacterial and viral communities in murine fecal samples to dietary changes between high- and low-fat (LF) diets. Targeted DNA extraction methods for bacteria, virus-like particles and induced prophages were used to generate bacterial and viral metagenomes as well as 16S ribosomal RNA amplicons. Gut microbiome communities from two cohorts of C57BL/6 mice were characterized in a 6-week diet perturbation study in response to high fiber, LF and high-refined sugar, milkfat (MF) diets. The resulting metagenomes from induced bacterial prophages and extracellular viruses showed significant overlap, supporting a largely temperate viral lifestyle within these gut microbiomes. The resistance of baseline communities to dietary disturbances was evaluated, and we observed contrasting responses of baseline LF and MF bacterial and viral communities. In contrast to baseline LF viral communities and bacterial communities in both diet treatments, baseline MF viral communities were sensitive to dietary disturbances as reflected in their non-recovery during the washout period. Finally, the contrasting responses of bacterial and viral communities suggest that these communities can respond to perturbations independently of each other and highlight the potentially unique role of viruses in gut health.},
doi = {10.1038/ismej.2015.183},
journal = {The ISME Journal},
number = 5,
volume = 10,
place = {United States},
year = {Fri Oct 16 00:00:00 EDT 2015},
month = {Fri Oct 16 00:00:00 EDT 2015}
}
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Works referenced in this record:
Bacteriophage adhering to mucus provide a non-host-derived immunity
journal, May 2013
- Barr, J. J.; Auro, R.; Furlan, M.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 26
Viral diversity and dynamics in an infant gut
journal, June 2008
- Breitbart, Mya; Haynes, Matthew; Kelley, Scott
- Research in Microbiology, Vol. 159, Issue 5
Host genetic and environmental effects on mouse intestinal microbiota
journal, June 2012
- Campbell, James H.; Foster, Carmen M.; Vishnivetskaya, Tatiana
- The ISME Journal, Vol. 6, Issue 11
Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
journal, March 2012
- Caporaso, J. Gregory; Lauber, Christian L.; Walters, William A.
- The ISME Journal, Vol. 6, Issue 8
Diet Dominates Host Genotype in Shaping the Murine Gut Microbiota
journal, January 2015
- Carmody, Rachel N.; Gerber, Georg K.; Luevano, Jesus M.
- Cell Host & Microbe, Vol. 17, Issue 1
Diet rapidly and reproducibly alters the human gut microbiome
journal, December 2013
- David, Lawrence A.; Maurice, Corinne F.; Carmody, Rachel N.
- Nature, Vol. 505, Issue 7484
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice
journal, June 2012
- Devkota, Suzanne; Wang, Yunwei; Musch, Mark W.
- Nature, Vol. 487, Issue 7405
A composite bacteriophage alters colonization by an intestinal commensal bacterium
journal, October 2012
- Duerkop, B. A.; Clements, C. V.; Rollins, D.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 43
Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity
journal, April 2014
- Everard, Amandine; Lazarevic, Vladimir; Gaïa, Nadia
- The ISME Journal, Vol. 8, Issue 10
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
journal, March 2014
- Gevers, Dirk; Kugathasan, Subra; Denson, Lee A.
- Cell Host & Microbe, Vol. 15, Issue 3
Bacteria-Phage Antagonistic Coevolution in Soil
journal, March 2011
- Gomez, P.; Buckling, A.
- Science, Vol. 332, Issue 6025
Tackling soil diversity with the assembly of large, complex metagenomes
journal, March 2014
- Howe, Adina Chuang; Jansson, Janet K.; Malfatti, Stephanie A.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 13
Obesity alters gut microbial ecology
journal, July 2005
- Ley, R. E.; Backhed, F.; Turnbaugh, P.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 31
Effects of Diet on Resource Utilization by a Model Human Gut Microbiota Containing Bacteroides cellulosilyticus WH2, a Symbiont with an Extensive Glycobiome
journal, August 2013
- McNulty, Nathan P.; Wu, Meng; Erickson, Alison R.
- PLoS Biology, Vol. 11, Issue 8
The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes
journal, September 2008
- Meyer, F.; Paarmann, D.; D'Souza, M.
- BMC Bioinformatics, Vol. 9, Issue 1
Hypervariable loci in the human gut virome
journal, February 2012
- Minot, S.; Grunberg, S.; Wu, G. D.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 10
The human gut virome: Inter-individual variation and dynamic response to diet
journal, August 2011
- Minot, S.; Sinha, R.; Chen, J.
- Genome Research, Vol. 21, Issue 10
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
journal, January 2015
- Norman, Jason M.; Handley, Scott A.; Baldridge, Megan T.
- Cell, Vol. 160, Issue 3
Scaling metagenome sequence assembly with probabilistic de Bruijn graphs
journal, July 2012
- Pell, J.; Hintze, A.; Canino-Koning, R.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 33
Viruses in the faecal microbiota of monozygotic twins and their mothers
journal, July 2010
- Reyes, Alejandro; Haynes, Matthew; Hanson, Nicole
- Nature, Vol. 466, Issue 7304
Going viral: next-generation sequencing applied to phage populations in the human gut
journal, August 2012
- Reyes, Alejandro; Semenkovich, Nicholas P.; Whiteson, Katrine
- Nature Reviews Microbiology, Vol. 10, Issue 9
Gnotobiotic mouse model of phage-bacterial host dynamics in the human gut
journal, November 2013
- Reyes, A.; Wu, M.; McNulty, N. P.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 50
Viruses manipulate the marine environment
journal, May 2009
- Rohwer, Forest; Thurber, Rebecca Vega
- Nature, Vol. 459, Issue 7244
Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission
journal, February 2014
- Rooks, Michelle G.; Veiga, Patrick; Wardwell-Scott, Leslie H.
- The ISME Journal, Vol. 8, Issue 7
Metavir 2: new tools for viral metagenome comparison and assembled virome analysis
journal, January 2014
- Roux, Simon; Tournayre, Jeremy; Mahul, Antoine
- BMC Bioinformatics, Vol. 15, Issue 1
Marine viruses — major players in the global ecosystem
journal, October 2007
- Suttle, Curtis A.
- Nature Reviews Microbiology, Vol. 5, Issue 10
The intestinal microbiota in aged mice is modulated by dietary resistant starch and correlated with improvements in host responses
journal, September 2012
- Tachon, Sybille; Zhou, June; Keenan, Michael
- FEMS Microbiology Ecology, Vol. 83, Issue 2
Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome
journal, April 2008
- Turnbaugh, Peter J.; Bäckhed, Fredrik; Fulton, Lucinda
- Cell Host & Microbe, Vol. 3, Issue 4
A core gut microbiome in obese and lean twins
journal, November 2008
- Turnbaugh, Peter J.; Hamady, Micah; Yatsunenko, Tanya
- Nature, Vol. 457, Issue 7228
An obesity-associated gut microbiome with increased capacity for energy harvest
journal, December 2006
- Turnbaugh, Peter J.; Ley, Ruth E.; Mahowald, Michael A.
- Nature, Vol. 444, Issue 7122
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
journal, November 2009
- Turnbaugh, P. J.; Ridaura, V. K.; Faith, J. J.
- Science Translational Medicine, Vol. 1, Issue 6
Dominant and diet-responsive groups of bacteria within the human colonic microbiota
journal, August 2010
- Walker, Alan W.; Ince, Jennifer; Duncan, Sylvia H.
- The ISME Journal, Vol. 5, Issue 2
Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations
journal, April 2012
- Zhang, Chenhong; Zhang, Menghui; Pang, Xiaoyan
- The ISME Journal, Vol. 6, Issue 10
Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome
journal, April 2008
- Turnbaugh, Peter J.; Bäckhed, Fredrik; Fulton, Lucinda
- Cell Host & Microbe, Vol. 3, Issue 4
Viral diversity and dynamics in an infant gut
journal, June 2008
- Breitbart, Mya; Haynes, Matthew; Kelley, Scott
- Research in Microbiology, Vol. 159, Issue 5
Prophage: a crucial catalyst in infectious disease modulation
journal, March 2022
- Nepal, Roshan; Houtak, Ghais; Wormald, Peter-John
- The Lancet Microbe, Vol. 3, Issue 3
Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations
journal, April 2012
- Zhang, Chenhong; Zhang, Menghui; Pang, Xiaoyan
- The ISME Journal, Vol. 6, Issue 10
Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission
journal, February 2014
- Rooks, Michelle G.; Veiga, Patrick; Wardwell-Scott, Leslie H.
- The ISME Journal, Vol. 8, Issue 7
Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity
journal, April 2014
- Everard, Amandine; Lazarevic, Vladimir; Gaïa, Nadia
- The ISME Journal, Vol. 8, Issue 10
Viruses manipulate the marine environment
journal, May 2009
- Rohwer, Forest; Thurber, Rebecca Vega
- Nature, Vol. 459, Issue 7244
Viruses in the faecal microbiota of monozygotic twins and their mothers
journal, July 2010
- Reyes, Alejandro; Haynes, Matthew; Hanson, Nicole
- Nature, Vol. 466, Issue 7304
Getting to the core of the gut microbiome
journal, April 2009
- Tschöp, Matthias H.; Hugenholtz, Philip; Karp, Christopher L.
- Nature Biotechnology, Vol. 27, Issue 4
Marine viruses — major players in the global ecosystem
journal, October 2007
- Suttle, Curtis A.
- Nature Reviews Microbiology, Vol. 5, Issue 10
Going viral: next-generation sequencing applied to phage populations in the human gut
journal, August 2012
- Reyes, Alejandro; Semenkovich, Nicholas P.; Whiteson, Katrine
- Nature Reviews Microbiology, Vol. 10, Issue 9
Obesity alters gut microbial ecology
journal, July 2005
- Ley, R. E.; Backhed, F.; Turnbaugh, P.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 31
Bacteriophage adhering to mucus provide a non-host-derived immunity
journal, May 2013
- Barr, J. J.; Auro, R.; Furlan, M.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 26
Gnotobiotic mouse model of phage-bacterial host dynamics in the human gut
journal, November 2013
- Reyes, A.; Wu, M.; McNulty, N. P.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 50
The human gut virome: Inter-individual variation and dynamic response to diet
journal, August 2011
- Minot, S.; Sinha, R.; Chen, J.
- Genome Research, Vol. 21, Issue 10
The intestinal microbiota in aged mice is modulated by dietary resistant starch and correlated with improvements in host responses
journal, September 2012
- Tachon, Sybille; Zhou, June; Keenan, Michael
- FEMS Microbiology Ecology, Vol. 83, Issue 2
Metavir 2: new tools for viral metagenome comparison and assembled virome analysis
journal, January 2014
- Roux, Simon; Tournayre, Jeremy; Mahul, Antoine
- BMC Bioinformatics, Vol. 15, Issue 1
The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes
journal, September 2008
- Meyer, F.; Paarmann, D.; D'Souza, M.
- BMC Bioinformatics, Vol. 9, Issue 1
Effects of Diet on Resource Utilization by a Model Human Gut Microbiota Containing Bacteroides cellulosilyticus WH2, a Symbiont with an Extensive Glycobiome
journal, August 2013
- McNulty, Nathan P.; Wu, Meng; Erickson, Alison R.
- PLoS Biology, Vol. 11, Issue 8
Scaling metagenome sequence assembly with probabilistic de Bruijn graphs
text, January 2011
- Pell, Jason; Hintze, Arend; Canino-Koning, Rosangela
- arXiv
Data from: Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome
dataset, January 2013
- McNulty, Nathan P.; Meng, Wu; Erickson, Alison R.
- Dryad
Works referencing / citing this record:
Effect of barley supplementation on the fecal microbiota, caecal biochemistry, and key biomarkers of obesity and inflammation in obese db/db mice
journal, August 2017
- Garcia-Mazcorro, Jose F.; Mills, David A.; Murphy, Kevin
- European Journal of Nutrition, Vol. 57, Issue 7
Lysogeny is prevalent and widely distributed in the murine gut microbiota
journal, February 2018
- Kim, Min-Soo; Bae, Jin-Woo
- The ISME Journal, Vol. 12, Issue 4
Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis
journal, December 2018
- Schwartz, Michael H.; Wang, Haipeng; Pan, Jessica N.
- Nature Communications, Vol. 9, Issue 1
Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children
journal, January 2019
- Mathew, Shilu; Smatti, Maria K.; Al Ansari, Khalid
- Scientific Reports, Vol. 9, Issue 1
The human gut virome: form and function
journal, November 2017
- Ogilvie, Lesley A.; Jones, Brian V.
- Emerging Topics in Life Sciences, Vol. 1, Issue 4
Consumption of a high-fat diet alters the seminal fluid and gut microbiomes in male mice
journal, January 2017
- Javurek, Angela B.; Spollen, William G.; Johnson, Sarah A.
- Reproduction, Fertility and Development, Vol. 29, Issue 8
Western diets, gut dysbiosis, and metabolic diseases: Are they linked?
journal, January 2017
- Martinez, Kristina B.; Leone, Vanessa; Chang, Eugene B.
- Gut Microbes, Vol. 8, Issue 2
Dietary prophage inducers and antimicrobials: toward landscaping the human gut microbiome
journal, January 2020
- Boling, Lance; Cuevas, Daniel A.; Grasis, Juris A.
- Gut Microbes, Vol. 11, Issue 4
Using noninvasive metagenomics to characterize viral communities from wildlife
journal, October 2018
- Bergner, Laura M.; Orton, Richard J.; da Silva Filipe, Ana
- Molecular Ecology Resources, Vol. 19, Issue 1
Thinking Outside the Cereal Box: Noncarbohydrate Routes for Dietary Manipulation of the Gut Microbiota
journal, November 2018
- Reese, Aspen T.; Carmody, Rachel N.
- Applied and Environmental Microbiology, Vol. 85, Issue 10
The In-Feed Antibiotic Carbadox Induces Phage Gene Transcription in the Swine Gut Microbiome
journal, August 2017
- Johnson, Timothy A.; Looft, Torey; Severin, Andrew J.
- mBio, Vol. 8, Issue 4
Bacteriophages: Uncharacterized and Dynamic Regulators of the Immune System
journal, September 2019
- Sinha, Anshul; Maurice, Corinne F.
- Mediators of Inflammation, Vol. 2019
The altered gut virome community in rhesus monkeys is correlated with the gut bacterial microbiome and associated metabolites
journal, August 2019
- Li, Heng; Li, Hongzhe; Wang, Jingjing
- Virology Journal, Vol. 16, Issue 1
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study
journal, January 2017
- Kang, Dae-Wook; Adams, James B.; Gregory, Ann C.
- Microbiome, Vol. 5, Issue 1
Dietary energy drives the dynamic response of bovine rumen viral communities
journal, November 2017
- Anderson, Christopher L.; Sullivan, Matthew B.; Fernando, Samodha C.
- Microbiome, Vol. 5, Issue 1
Using pseudoalignment and base quality to accurately quantify microbial community composition
journal, April 2018
- Reppell, Mark; Novembre, John
- PLOS Computational Biology, Vol. 14, Issue 4
Bacteriophages shift the focus of the mammalian microbiota
journal, October 2018
- Duerkop, Breck A.
- PLOS Pathogens, Vol. 14, Issue 10
Phage Therapy: Beyond Antibacterial Action
journal, May 2018
- Górski, Andrzej; Jończyk-Matysiak, Ewa; Międzybrodzki, Ryszard
- Frontiers in Medicine, Vol. 5
Phages in the Human Body
journal, April 2017
- Navarro, Ferran; Muniesa, Maite
- Frontiers in Microbiology, Vol. 8
Metabolic Modeling Elucidates the Transactions in the Rumen Microbiome and the Shifts Upon Virome Interactions
journal, October 2019
- Islam, Mohammad Mazharul; Fernando, Samodha C.; Saha, Rajib
- Frontiers in Microbiology, Vol. 10
The Human Gut Phage Community and Its Implications for Health and Disease
journal, June 2017
- Manrique, Pilar; Dills, Michael; Young, Mark
- Viruses, Vol. 9, Issue 6
Gut microbiota dysbiosis associated with glucose metabolism disorders and the metabolic syndrome in older adults
journal, August 2017
- Lippert, K.; Kedenko, L.; Antonielli, L.
- Beneficial Microbes, Vol. 8, Issue 4
Using pseudoalignment and base quality to accurately quantify microbial community composition
posted_content, January 2017
- Reppell, M.; Novembre, J.
- PLOS Computational Biology
Mouse Vendor Influence on the Bacterial and Viral Gut Composition Exceeds the Effect of Diet
journal, May 2019
- Rasmussen, Torben Sølbeck; de Vries, Liv; Kot, Witold
- Viruses, Vol. 11, Issue 5
Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis
journal, December 2018
- Schwartz, Michael H.; Wang, Haipeng; Pan, Jessica N.
- Nature Communications, Vol. 9, Issue 1
Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children
journal, January 2019
- Mathew, Shilu; Smatti, Maria K.; Al Ansari, Khalid
- Scientific Reports, Vol. 9, Issue 1
Using pseudoalignment and base quality to accurately quantify microbial community composition
posted_content, January 2017
- Reppell, M.; Novembre, J.
- PLOS Computational Biology
Environmental plasticity and colonisation history in the Atlantic salmon microbiome: a translocation experiment
journal, March 2019
- Uren Webster, Tamsyn M.; Rodriguez-Barreto, Deiene; Castaldo, Giovanni
- Molecular Ecology
Environmental plasticity and colonisation history in the Atlantic salmon microbiome: A translocation experiment
journal, February 2020
- Uren Webster, Tamsyn M.; Rodriguez‐Barreto, Deiene; Castaldo, Giovanni
- Molecular Ecology, Vol. 29, Issue 5
Prophages in Lactobacillus reuteri Are Associated with Fitness Trade-Offs but Can Increase Competitiveness in the Gut Ecosystem
journal, December 2019
- Oh, Jee-Hwan; Lin, Xiaoxi B.; Zhang, Shenwei
- Applied and Environmental Microbiology, Vol. 86, Issue 1
Fecal Viral Community Responses to High-Fat Diet in Mice
journal, February 2020
- Schulfer, Anjelique; Santiago-Rodriguez, Tasha M.; Ly, Melissa
- mSphere, Vol. 5, Issue 1
Considering the Other Half of the Gut Microbiome: Bacteriophages
journal, June 2019
- Maurice, Corinne F.
- mSystems, Vol. 4, Issue 3
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study
journal, January 2017
- Kang, Dae-Wook; Adams, James B.; Gregory, Ann C.
- Microbiome, Vol. 5, Issue 1
Dietary energy drives the dynamic response of bovine rumen viral communities
journal, November 2017
- Anderson, Christopher L.; Sullivan, Matthew B.; Fernando, Samodha C.
- Microbiome, Vol. 5, Issue 1
Microbial Ecology along the Gastrointestinal Tract
journal, January 2017
- Hillman, Ethan T.; Lu, Hang; Yao, Tianming
- Microbes and Environments, Vol. 32, Issue 4
A theoretical model of temperate phages as mediators of gut microbiome dysbiosis
journal, July 2019
- Lin, Derek M.; Lin, Henry C.
- F1000Research, Vol. 8
Bacteriophages shift the focus of the mammalian microbiota
journal, October 2018
- Duerkop, Breck A.
- PLOS Pathogens, Vol. 14, Issue 10
The Human Gut Phage Community and Its Implications for Health and Disease
journal, June 2017
- Manrique, Pilar; Dills, Michael; Young, Mark
- Viruses, Vol. 9, Issue 6
How the other half lives: CRISPR-Cas's influence on bacteriophages
text, January 2017
- Bonomo, Melia E.; Deem, Michael W.
- arXiv
Assessing Illumina technology for the high-throughput sequencing of bacteriophage genomes
journal, June 2016
- Rihtman, Branko; Meaden, Sean; Clokie, Martha R. J.
- PeerJ, Vol. 4