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Title: Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion

Recently, predominantly closed-cell low density shape memory polymer (SMP) foam was reported to be an effective aneurysm filling device in a porcine model (Rodriguez et al., Journal of Biomedical Materials Research Part A 2013: (http://dx.doi.org/10.1002/jbm.a.34782)). Because healing involves blood clotting and cell migration throughout the foam volume, a more open-cell structure may further enhance the healing response. This research sought to develop a non-destructive reticulation process for this SMP foam to disrupt the membranes between pore cells. Non-destructive mechanical reticulation was achieved using a gravity-driven floating nitinol pin array coupled with vibratory agitation of the foam and supplemental chemical etching. Lastly, reticulation resulted in a reduced elastic modulus and increased permeability, but did not impede the shape memory behavior. Reticulated foams were capable of achieving rapid vascular occlusion in an in vivo porcine model.
Authors:
 [1] ;  [2] ;  [1] ;  [1] ;  [3] ;  [4] ;  [4] ;  [4] ;  [1] ;  [1] ;  [1]
  1. Texas A&M Univ., College Station, TX (United States). Dept. of Biomedical Engineering
  2. Texas A&M Univ., College Station, TX (United States). Texas Inst. for Preclinical Studies
  3. Texas A&M Univ., College Station, TX (United States). Dept. of Mechanical Engineering
  4. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Publication Date:
OSTI Identifier:
1282115
Grant/Contract Number:
AC52-07NA27344; R01EB000462
Type:
Accepted Manuscript
Journal Name:
Journal of the Mechanical Behavior of Biomedical Materials
Additional Journal Information:
Journal Volume: 40; Journal Issue: C; Journal ID: ISSN 1751-6161
Publisher:
Elsevier
Research Org:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE; National Inst. of Health (NIH)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES