Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion
Abstract
Recently, predominantly closed-cell low density shape memory polymer (SMP) foam was reported to be an effective aneurysm filling device in a porcine model (Rodriguez et al., Journal of Biomedical Materials Research Part A 2013: (http://dx.doi.org/10.1002/jbm.a.34782)). Because healing involves blood clotting and cell migration throughout the foam volume, a more open-cell structure may further enhance the healing response. This research sought to develop a non-destructive reticulation process for this SMP foam to disrupt the membranes between pore cells. Non-destructive mechanical reticulation was achieved using a gravity-driven floating nitinol pin array coupled with vibratory agitation of the foam and supplemental chemical etching. Lastly, reticulation resulted in a reduced elastic modulus and increased permeability, but did not impede the shape memory behavior. Reticulated foams were capable of achieving rapid vascular occlusion in an in vivo porcine model.
- Authors:
-
- Texas A & M Univ., College Station, TX (United States)
- Texas A & M Univ., College Station, TX (United States). Inst. for Preclinical Studies
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH)
- OSTI Identifier:
- 1763946
- Alternate Identifier(s):
- OSTI ID: 1282115; OSTI ID: 1556639
- Report Number(s):
- LLNL-JRNL-651670
Journal ID: ISSN 1751-6161; 772029
- Grant/Contract Number:
- AC52-07NA27344; R01EB000462
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of the Mechanical Behavior of Biomedical Materials
- Additional Journal Information:
- Journal Volume: 40; Journal Issue: na; Journal ID: ISSN 1751-6161
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Rodriguez, Jennifer N., Miller, Matthew W., Boyle, Anthony, Horn, John, Yang, Cheng-Kang, Wilson, Thomas S., Ortega, Jason M., Small, Ward, Nash, Landon, Skoog, Hunter, and Maitland, Duncan J. Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion. United States: N. p., 2014.
Web. doi:10.1016/j.jmbbm.2014.07.037.
Rodriguez, Jennifer N., Miller, Matthew W., Boyle, Anthony, Horn, John, Yang, Cheng-Kang, Wilson, Thomas S., Ortega, Jason M., Small, Ward, Nash, Landon, Skoog, Hunter, & Maitland, Duncan J. Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion. United States. https://doi.org/10.1016/j.jmbbm.2014.07.037
Rodriguez, Jennifer N., Miller, Matthew W., Boyle, Anthony, Horn, John, Yang, Cheng-Kang, Wilson, Thomas S., Ortega, Jason M., Small, Ward, Nash, Landon, Skoog, Hunter, and Maitland, Duncan J. Mon .
"Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion". United States. https://doi.org/10.1016/j.jmbbm.2014.07.037. https://www.osti.gov/servlets/purl/1763946.
@article{osti_1763946,
title = {Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion},
author = {Rodriguez, Jennifer N. and Miller, Matthew W. and Boyle, Anthony and Horn, John and Yang, Cheng-Kang and Wilson, Thomas S. and Ortega, Jason M. and Small, Ward and Nash, Landon and Skoog, Hunter and Maitland, Duncan J.},
abstractNote = {Recently, predominantly closed-cell low density shape memory polymer (SMP) foam was reported to be an effective aneurysm filling device in a porcine model (Rodriguez et al., Journal of Biomedical Materials Research Part A 2013: (http://dx.doi.org/10.1002/jbm.a.34782)). Because healing involves blood clotting and cell migration throughout the foam volume, a more open-cell structure may further enhance the healing response. This research sought to develop a non-destructive reticulation process for this SMP foam to disrupt the membranes between pore cells. Non-destructive mechanical reticulation was achieved using a gravity-driven floating nitinol pin array coupled with vibratory agitation of the foam and supplemental chemical etching. Lastly, reticulation resulted in a reduced elastic modulus and increased permeability, but did not impede the shape memory behavior. Reticulated foams were capable of achieving rapid vascular occlusion in an in vivo porcine model.},
doi = {10.1016/j.jmbbm.2014.07.037},
journal = {Journal of the Mechanical Behavior of Biomedical Materials},
number = na,
volume = 40,
place = {United States},
year = {Mon Dec 01 00:00:00 EST 2014},
month = {Mon Dec 01 00:00:00 EST 2014}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 32 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association
journal, March 2009
- Bederson, Joshua B.; Connolly, E. Sander; Batjer, H. Hunt
- Stroke, Vol. 40, Issue 3
In vivo response to an implanted shape memory polyurethane foam in a porcine aneurysm model
journal, May 2013
- Rodriguez, Jennifer N.; Clubb, Fred J.; Wilson, Thomas S.
- Journal of Biomedical Materials Research Part A, Vol. 102, Issue 5, p. 1231-1242
Treatment of type II endoleaks with a novel polyurethane thrombogenic foam: Induction of endoleak thrombosis and elimination of intra-aneurysmal pressure in the canine model
journal, August 2005
- Rhee, Jason Y.; Trocciola, Susan M.; Dayal, Rajeev
- Journal of Vascular Surgery, Vol. 42, Issue 2
Quantitative Characterization of the Hemodynamic Environment in Ruptured and Unruptured Brain Aneurysms
journal, December 2010
- Cebral, J. R.; Mut, F.; Weir, J.
- American Journal of Neuroradiology, Vol. 32, Issue 1
Controlling the Actuation Rate of Low-Density Shape-Memory Polymer Foams in Water
journal, October 2012
- Singhal, Pooja; Boyle, Anthony; Brooks, Marilyn L.
- Macromolecular Chemistry and Physics, Vol. 214, Issue 11, p. 1204-1214
Opacification of Shape Memory Polymer Foam Designed for Treatment of Intracranial Aneurysms
journal, November 2011
- Rodriguez, Jennifer N.; Yu, Ya-Jen; Miller, Matthew W.
- Annals of Biomedical Engineering, Vol. 40, Issue 4
Ultra low density and highly crosslinked biocompatible shape memory polyurethane foams
journal, March 2012
- Singhal, Pooja; Rodriguez, Jennifer N.; Small, Ward
- Journal of Polymer Science Part B: Polymer Physics, Vol. 50, Issue 10, p. 724-737
Estimating the Coefficient of Inertial Resistance in Fluid Flow Through Porous Media
journal, October 1974
- Geertsma, J.
- Society of Petroleum Engineers Journal, Vol. 14, Issue 05
Evaluation of a Novel Endoluminal Vascular Occlusion Device in a Porcine Model : Early and Late Follow-up
journal, August 2005
- Kipshidze, Nicholas; Sadzaglishvili, Kakha; Panarella, Matthew
- Journal of Endovascular Therapy, Vol. 12, Issue 4
Works referencing / citing this record:
Advances in Biomaterials and Technologies for Vascular Embolization
journal, June 2019
- Hu, Jingjie; Albadawi, Hassan; Chong, Brian W.
- Advanced Materials, Vol. 31, Issue 33
Multifunctional Shape-Memory Polymer Foams with Bio-inspired Antimicrobials
journal, December 2017
- Monroe, Mary Beth Browning; Easley, Alexandra D.; Grant, Katie
- ChemPhysChem, Vol. 19, Issue 16
Porous shape memory polymers: Design and applications
journal, January 2016
- Hasan, Sayyeda M.; Nash, Landon D.; Maitland, Duncan J.
- Journal of Polymer Science Part B: Polymer Physics, Vol. 54, Issue 14
Shape-morphing composites with designed micro-architectures
journal, June 2016
- Rodriguez, Jennifer N.; Zhu, Cheng; Duoss, Eric B.
- Scientific Reports, Vol. 6, Issue 1
Shape-morphing composites with designed micro-architectures
journal, June 2016
- Rodriguez, Jennifer N.; Zhu, Cheng; Duoss, Eric B.
- Scientific Reports, Vol. 6, Issue 1