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Title: Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug

Abstract

We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.

Authors:
 [1];  [1];  [2];  [2];  [1];  [2];  [2];  [1]
  1. Department of Chemical and Biomolecular Engineering, University of California−Berkeley, Berkeley, California 94720, United States
  2. Department of Radiology and Biomedical Imaging, University of California−San Francisco, San Francisco, California 94107, United States
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States); Univ. of California, San Francisco, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES); National Inst. of Health (NIH) (United States)
OSTI Identifier:
1271469
Alternate Identifier(s):
OSTI ID: 1314044; OSTI ID: 1373378; OSTI ID: 1474958
Report Number(s):
LBNL-1005980
Journal ID: ISSN 2161-1653
Grant/Contract Number:  
AC02-05CH11231; 1R01CA194533; 1R41CA183327
Resource Type:
Published Article
Journal Name:
ACS Macro Letters
Additional Journal Information:
Journal Name: ACS Macro Letters Journal Volume: 5 Journal Issue: 8; Journal ID: ISSN 2161-1653
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Chen, X. Chelsea, Oh, Hee Jeung, Yu, Jay F., Yang, Jeffrey K., Petzetakis, Nikos, Patel, Anand S., Hetts, Steven W., and Balsara, Nitash P.. Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug. United States: N. p., 2016. Web. https://doi.org/10.1021/acsmacrolett.6b00459.
Chen, X. Chelsea, Oh, Hee Jeung, Yu, Jay F., Yang, Jeffrey K., Petzetakis, Nikos, Patel, Anand S., Hetts, Steven W., & Balsara, Nitash P.. Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug. United States. https://doi.org/10.1021/acsmacrolett.6b00459
Chen, X. Chelsea, Oh, Hee Jeung, Yu, Jay F., Yang, Jeffrey K., Petzetakis, Nikos, Patel, Anand S., Hetts, Steven W., and Balsara, Nitash P.. Sat . "Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug". United States. https://doi.org/10.1021/acsmacrolett.6b00459.
@article{osti_1271469,
title = {Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug},
author = {Chen, X. Chelsea and Oh, Hee Jeung and Yu, Jay F. and Yang, Jeffrey K. and Petzetakis, Nikos and Patel, Anand S. and Hetts, Steven W. and Balsara, Nitash P.},
abstractNote = {We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.},
doi = {10.1021/acsmacrolett.6b00459},
journal = {ACS Macro Letters},
number = 8,
volume = 5,
place = {United States},
year = {2016},
month = {7}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1021/acsmacrolett.6b00459

Citation Metrics:
Cited by: 2 works
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Works referenced in this record:

Sulfonated hydrocarbon membranes for medium-temperature and low-humidity proton exchange membrane fuel cells (PEMFCs)
journal, November 2011


A review of reverse osmosis membrane materials for desalination—Development to date and future potential
journal, March 2011


Adsorption of drugs onto a poly(acrylic acid) grafted cation-exchange membrane
journal, December 1999


Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications
journal, September 2010

  • Shi, Jinjun; Votruba, Alexander R.; Farokhzad, Omid C.
  • Nano Letters, Vol. 10, Issue 9
  • DOI: 10.1021/nl102184c

Dendrimers and dendritic polymers in drug delivery
journal, January 2005


Morphology–Conductivity Relationship of Single-Ion-Conducting Block Copolymer Electrolytes for Lithium Batteries
journal, May 2014

  • Inceoglu, Sebnem; Rojas, Adriana A.; Devaux, Didier
  • ACS Macro Letters, Vol. 3, Issue 6
  • DOI: 10.1021/mz5001948

Ion-exchange resins: carrying drug delivery forward
journal, September 2001


Water permeability and water/salt selectivity tradeoff in polymers for desalination
journal, March 2011


Biodegradable block copolymers as injectable drug-delivery systems
journal, August 1997

  • Jeong, Byeongmoon; Bae, You Han; Lee, Doo Sung
  • Nature, Vol. 388, Issue 6645
  • DOI: 10.1038/42218

Anion exchange membranes: Current status and moving forward
journal, October 2013

  • Hickner, Michael A.; Herring, Andrew M.; Coughlin, E. Bryan
  • Journal of Polymer Science Part B: Polymer Physics, Vol. 51, Issue 24, p. 1727-1735
  • DOI: 10.1002/polb.23395

Compliant glass–polymer hybrid single ion-conducting electrolytes for lithium batteries
journal, December 2015

  • Villaluenga, Irune; Wujcik, Kevin H.; Tong, Wei
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 1
  • DOI: 10.1073/pnas.1520394112

Water Uptake and Proton Conductivity in Porous Block Copolymer Electrolyte Membranes
journal, August 2015


Development and Validation of Endovascular Chemotherapy Filter Device for Removing High-Dose Doxorubicin: Preclinical Study
journal, August 2014

  • Patel, Anand S.; Saeed, Maythem; Yee, Erin J.
  • Journal of Medical Devices, Vol. 8, Issue 4
  • DOI: 10.1115/1.4027444

Trans-catheter arterial chemoembolization as first-line treatment for hepatic metastases from endocrine tumors
journal, January 2003


Risk Factors for Doxorubicin-lnduced Congestive Heart Failure
journal, November 1979


A novel approach for preparation of pH-sensitive hydrogels for enteric drug delivery
journal, April 1991


Boronated starburst dendrimer-monoclonal antibody immunoconjugates: Evaluation as a potential delivery system for neutron capture therapy
journal, January 1994

  • Barth, Rolf F.; Adams, Dianne M.; Soloway, Albert H.
  • Bioconjugate Chemistry, Vol. 5, Issue 1
  • DOI: 10.1021/bc00025a008

Enhanced angiogenesis through controlled release of basic fibroblast growth factor from peptide amphiphile for tissue regeneration
journal, December 2006


Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems
journal, November 2006

  • Nasongkla, Norased; Bey, Erik; Ren, Jimin
  • Nano Letters, Vol. 6, Issue 11
  • DOI: 10.1021/nl061412u

Highly Chlorine-Tolerant Polymers for Desalination
journal, July 2008

  • Park, Ho Bum; Freeman, Benny D.; Zhang, Zhong-Bio
  • Angewandte Chemie International Edition, Vol. 47, Issue 32
  • DOI: 10.1002/anie.200800454

Single-ion BAB triblock copolymers as highly efficient electrolytes for lithium-metal batteries
journal, March 2013

  • Bouchet, Renaud; Maria, Sébastien; Meziane, Rachid
  • Nature Materials, Vol. 12, Issue 5
  • DOI: 10.1038/nmat3602

Design of Environment-Sensitive Supramolecular Assemblies for Intracellular Drug Delivery: Polymeric Micelles that are Responsive to Intracellular pH Change
journal, October 2003

  • Bae, Younsoo; Fukushima, Shigeto; Harada, Atsushi
  • Angewandte Chemie International Edition, Vol. 42, Issue 38
  • DOI: 10.1002/anie.200250653

Effect of Morphology of Nanoscale Hydrated Channels on Proton Conductivity in Block Copolymer Electrolyte Membranes
journal, June 2014

  • Chen, X. Chelsea; Wong, David T.; Yakovlev, Sergey
  • Nano Letters, Vol. 14, Issue 7
  • DOI: 10.1021/nl501537p

Block Copolymers for Fuel Cells
journal, January 2011

  • Elabd, Yossef A.; Hickner, Michael A.
  • Macromolecules, Vol. 44, Issue 1
  • DOI: 10.1021/ma101247c

Evaluation of Doxorubicin-Loaded 3-Helix Micelles as Nanocarriers
journal, September 2013

  • Dube, Nikhil; Shu, Jessica Y.; Dong, He
  • Biomacromolecules, Vol. 14, Issue 10
  • DOI: 10.1021/bm4010518

A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery
journal, October 2009

  • Hoare, Todd; Santamaria, Jesus; Goya, Gerardo F.
  • Nano Letters, Vol. 9, Issue 10
  • DOI: 10.1021/nl9018935

Nonresectable Hepatocellular Carcinoma: Long-term Toxicity in Patients Treated with Transarterial Chemoembolization—Single-Center Experience
journal, October 2008


Review on transarterial chemoembolization in hepatocellular carcinoma: Palliative, combined, neoadjuvant, bridging, and symptomatic indications
journal, December 2009

  • Vogl, Thomas J.; Naguib, Nagy N. N.; Nour-Eldin, Nour-Eldin A.
  • European Journal of Radiology, Vol. 72, Issue 3
  • DOI: 10.1016/j.ejrad.2008.08.007

Biodegradable polymeric nanoparticles as drug delivery devices
journal, January 2001

  • Soppimath, Kumaresh S.; Aminabhavi, Tejraj M.; Kulkarni, Anandrao R.
  • Journal of Controlled Release, Vol. 70, Issue 1-2
  • DOI: 10.1016/S0168-3659(00)00339-4