A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices
Abstract
Devices resident in the stomach used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric-retentive dosage forms for prolonged drug delivery typically incorporate elastic polymers to compress the devices during delivery through the oesophagus and other narrow orifices in the digestive system. In the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. We determine that these enteric elastomers should increase the safety profile for a wide range of gastricretentive devices.
- Authors:
-
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Harvard Medical School, Boston, MA (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Texas A & M Univ., College Station, TX (United States)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1265875
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Materials
- Additional Journal Information:
- Journal Volume: 14; Journal Issue: 10; Journal ID: ISSN 1476-1122
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; hydrogel; gastric devices; synchrotron x-ray scattering
Citation Formats
Zhang, Shiyi, Bellinger, Andrew M., Glettig, Dean L., Barman, Ross, Lee, Young-Ah Lucy, Zhu, Jiahua, Cleveland, Cody, Montgomery, Veronica A., Gu, Li, Nash, Landon D., Maitland, Duncan J., Langer, Robert, and Traverso, Giovanni. A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices. United States: N. p., 2015.
Web. doi:10.1038/nmat4355.
Zhang, Shiyi, Bellinger, Andrew M., Glettig, Dean L., Barman, Ross, Lee, Young-Ah Lucy, Zhu, Jiahua, Cleveland, Cody, Montgomery, Veronica A., Gu, Li, Nash, Landon D., Maitland, Duncan J., Langer, Robert, & Traverso, Giovanni. A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices. United States. https://doi.org/10.1038/nmat4355
Zhang, Shiyi, Bellinger, Andrew M., Glettig, Dean L., Barman, Ross, Lee, Young-Ah Lucy, Zhu, Jiahua, Cleveland, Cody, Montgomery, Veronica A., Gu, Li, Nash, Landon D., Maitland, Duncan J., Langer, Robert, and Traverso, Giovanni. Mon .
"A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices". United States. https://doi.org/10.1038/nmat4355. https://www.osti.gov/servlets/purl/1265875.
@article{osti_1265875,
title = {A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices},
author = {Zhang, Shiyi and Bellinger, Andrew M. and Glettig, Dean L. and Barman, Ross and Lee, Young-Ah Lucy and Zhu, Jiahua and Cleveland, Cody and Montgomery, Veronica A. and Gu, Li and Nash, Landon D. and Maitland, Duncan J. and Langer, Robert and Traverso, Giovanni},
abstractNote = {Devices resident in the stomach used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric-retentive dosage forms for prolonged drug delivery typically incorporate elastic polymers to compress the devices during delivery through the oesophagus and other narrow orifices in the digestive system. In the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. We determine that these enteric elastomers should increase the safety profile for a wide range of gastricretentive devices.},
doi = {10.1038/nmat4355},
journal = {Nature Materials},
number = 10,
volume = 14,
place = {United States},
year = {Mon Jul 27 00:00:00 EDT 2015},
month = {Mon Jul 27 00:00:00 EDT 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 238 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Endoluminal bariatric techniques
journal, July 2012
- Kethu, Sripathi R.; Banerjee, Subbhas; Barth, Bradley A.
- Gastrointestinal Endoscopy, Vol. 76, Issue 1
BioEnterics Intragastric Balloon: The Italian Experience with 2,515 Patients
journal, September 2005
- Genco, A.; Bruni, T.; Doldi, S. B.
- Obesity Surgery, Vol. 15, Issue 8
Oligopeptide complex for targeted non-viral gene delivery to adipocytes
journal, October 2014
- Won, Young-Wook; Adhikary, Partho Protim; Lim, Kwang Suk
- Nature Materials, Vol. 13, Issue 12
Silk-Based Conformal, Adhesive, Edible Food Sensors
journal, January 2012
- Tao, Hu; Brenckle, Mark A.; Yang, Miaomiao
- Advanced Materials, Vol. 24, Issue 8
Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices
journal, December 2013
- Kim, Y. J.; Wu, W.; Chun, S. -E.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 52
The ingestible telemetric body core temperature sensor: a review of validity and exercise applications
journal, March 2007
- Byrne, C.; Lim, C. L.
- British Journal of Sports Medicine, Vol. 41, Issue 3
Feasibility of an Ingestible Sensor-Based System for Monitoring Adherence to Tuberculosis Therapy
journal, January 2013
- Belknap, Robert; Weis, Steve; Brookens, Andrew
- PLoS ONE, Vol. 8, Issue 1
Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention
journal, February 2000
- Singh, B.
- Journal of Controlled Release, Vol. 63, Issue 3
Sustained gastrointestinal activity of dendronized polymer–enzyme conjugates
journal, June 2013
- Fuhrmann, Gregor; Grotzky, Andrea; Lukić, Ružica
- Nature Chemistry, Vol. 5, Issue 7
Localization of magnetic pills
journal, January 2011
- Laulicht, B.; Gidmark, N. J.; Tripathi, A.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 6
Measurement of the diameter of the pylorus in man
journal, September 1972
- Salessiotis, Nikolaos
- The American Journal of Surgery, Vol. 124, Issue 3
Direct measurement of pyloric diameter and tone in man and their response to cholecystokinin
book, January 1978
- Munk, J. F.; Gannaway, R. M.; Hoare, M.
- Gastrointestinal Motility in Health and Disease
Esophageal diameter and the treatment of achalasia
journal, September 1969
- Sultan, Michael; Norton, Richard A.
- The American Journal of Digestive Diseases, Vol. 14, Issue 9
A new endoscopic elastic band ligating device
journal, June 1986
- Van Stiegmann, Greg; Cambre, Tel; Sun, John H.
- Gastrointestinal Endoscopy, Vol. 32, Issue 3
Evidence-based Review of the Bioenterics Intragastric Balloon for Weight Loss
journal, June 2008
- Dumonceau, Jean-Marc
- Obesity Surgery, Vol. 18, Issue 12
The Risk of Retention of the Capsule Endoscope in Patients with Known or Suspected Crohn's Disease
journal, October 2006
- Cheifetz, Adam S.; Kornbluth, Asher A.; Legnani, Peter
- The American Journal of Gastroenterology, Vol. 101, Issue 10
Efficacy, Tolerance and Safety of New Intragastric Air-Filled Balloon (Heliosphere BAG) for Obesity: the Experience of 17 Cases
journal, December 2008
- Trande, Paolo; Mussetto, Alessandro; Mirante, Vincenzo G.
- Obesity Surgery, Vol. 20, Issue 9
Intragastric Balloon for "Non-Morbid" Obesity: A Retrospective Evaluation of Tolerance and Efficacy
journal, April 2004
- Roman, Sabine; Napoléon, Bertrand; Mion, François
- Obesity Surgery, Vol. 14, Issue 4
Perspective: Special delivery for the gut
journal, March 2015
- Traverso, Giovanni; Langer, Robert
- Nature, Vol. 519, Issue 7544
Synthetic Polymers as Potential Enteric and Sustained-Release Coatings
journal, August 1962
- Lappas, Lewis C.; McKeehan, Wayne
- Journal of Pharmaceutical Sciences, Vol. 51, Issue 8
Polymer blends for controlled release coatings
journal, January 2008
- Siepmann, F.; Siepmann, J.; Walther, M.
- Journal of Controlled Release, Vol. 125, Issue 1
Stimuli-responsive supramolecular polymeric materials
journal, January 2012
- Yan, Xuzhou; Wang, Feng; Zheng, Bo
- Chemical Society Reviews, Vol. 41, Issue 18
Using the dynamic bond to access macroscopically responsive structurally dynamic polymers
journal, December 2010
- Wojtecki, Rudy J.; Meador, Michael A.; Rowan, Stuart J.
- Nature Materials, Vol. 10, Issue 1
Shape-Memory Effects in Polymer Networks Containing Reversibly Associating Side-Groups
journal, October 2007
- Li, J.; Viveros, J. A.; Wrue, M. H.
- Advanced Materials, Vol. 19, Issue 19
A Multiresponsive, Shape-Persistent, and Elastic Supramolecular Polymer Network Gel Constructed by Orthogonal Self-Assembly
journal, December 2011
- Yan, Xuzhou; Xu, Donghua; Chi, Xiaodong
- Advanced Materials, Vol. 24, Issue 3
Controlled Supramolecular Assembly of Micelle-Like Gold Nanoparticles in PS- b -P2VP Diblock Copolymers via Hydrogen Bonding
journal, October 2011
- Jang, Se Gyu; Kramer, Edward J.; Hawker, Craig J.
- Journal of the American Chemical Society, Vol. 133, Issue 42
An electrically and mechanically self-healing composite with pressure- and flexion-sensitive properties for electronic skin applications
journal, November 2012
- Tee, Benjamin C-K.; Wang, Chao; Allen, Ranulfo
- Nature Nanotechnology, Vol. 7, Issue 12
Multiphase design of autonomic self-healing thermoplastic elastomers
journal, April 2012
- Chen, Yulin; Kushner, Aaron M.; Williams, Gregory A.
- Nature Chemistry, Vol. 4, Issue 6
Saloplastics: Processing Compact Polyelectrolyte Complexes
journal, March 2015
- Schaaf, Pierre; Schlenoff, Joseph B.
- Advanced Materials, Vol. 27, Issue 15
Advanced Functional Polymers for Medicine
journal, December 2014
- Lendlein, Andreas; Neffe, Axel T.; Jérôme, Christine
- Advanced Healthcare Materials, Vol. 3, Issue 12
Emerging applications of stimuli-responsive polymer materials
journal, January 2010
- Stuart, Martien A. Cohen; Huck, Wilhelm T. S.; Genzer, Jan
- Nature Materials, Vol. 9, Issue 2, p. 101-113
Floating Drug Delivery Systems for Prolonging Gastric Residence Time: A Review
journal, September 2011
- Sathish, D.; Himabindu, S.; Shravan Kumar, Y.
- Current Drug Delivery, Vol. 8, Issue 5
Rapid self-healing hydrogels
journal, March 2012
- Phadke, A.; Zhang, C.; Arman, B.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 12, p. 4383-4388
Structure and hydrogen bond dynamics of water–dimethyl sulfoxide mixtures by computer simulations
journal, May 1993
- Luzar, Alenka; Chandler, David
- The Journal of Chemical Physics, Vol. 98, Issue 10
The return of a forgotten polymer—Polycaprolactone in the 21st century
journal, October 2010
- Woodruff, Maria Ann; Hutmacher, Dietmar Werner
- Progress in Polymer Science, Vol. 35, Issue 10
Macroscale delivery systems for molecular and cellular payloads
journal, October 2013
- Kearney, Cathal J.; Mooney, David J.
- Nature Materials, Vol. 12, Issue 11
The effect of tablet size on the gastric emptying of non-disintegrating tablets
journal, July 1990
- Khosla, R.; Davis, S. S.
- International Journal of Pharmaceutics, Vol. 62, Issue 2-3
Controlled Gastric Emptying. 1. Effects of Physical Properties on Gastric Residence Times of Nondisintegrating Geometric Shapes in Beagle Dogs
journal, January 1988
- Cargill, Robyn; Caldwell, Larry J.; Engle, Karen
- Pharmaceutical Research, Vol. 05, Issue 8, p. 533-536
Factors Influencing the Gastric Residence of Dosage Forms in Dogs
journal, March 2009
- Martinez, Marilyn N.; Papich, Mark G.
- Journal of Pharmaceutical Sciences, Vol. 98, Issue 3
Swine as Models in Biomedical Research and Toxicology Testing
journal, January 2011
- Swindle, M. M.; Makin, A.; Herron, A. J.
- Veterinary Pathology, Vol. 49, Issue 2
Aqueous gel permeation chromatography: The effect of solvent ionic strength
journal, January 1979
- Cooper, Anthony R.; Matzinger, David P.
- Journal of Applied Polymer Science, Vol. 23, Issue 2
Advanced Functional Polymers for Medicine
journal, December 2016
- Neffe, Axel T.; Grijpma, Dirk W.; Lendlein, Andreas
- Macromolecular Bioscience, Vol. 16, Issue 12
Works referencing / citing this record:
Radiopaque Highly Stiff and Tough Shape Memory Hydrogel Microcoils for Permanent Embolization of Arteries
journal, January 2018
- Zhang, Yinyu; Gao, Haijun; Wang, Hao
- Advanced Functional Materials, Vol. 28, Issue 9
Programmable Hierarchical Kirigami
journal, November 2019
- An, Ning; Domel, August G.; Zhou, Jinxiong
- Advanced Functional Materials, Vol. 30, Issue 6
Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome
journal, September 2016
- Anselmo, Aaron C.; McHugh, Kevin J.; Webster, Jamie
- Advanced Materials, Vol. 28, Issue 43
Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery
journal, February 2017
- Ramin, Michael A.; Sindhu, Kotagudda Ranganath; Appavoo, Ananda
- Advanced Materials, Vol. 29, Issue 13
Advances in Biomaterials for Drug Delivery
journal, May 2018
- Fenton, Owen S.; Olafson, Katy N.; Pillai, Padmini S.
- Advanced Materials, Vol. 30, Issue 29
Programmable Self‐Assembling 3D Architectures Generated by Patterning of Swellable MOF‐Based Composite Films
journal, April 2019
- Troyano, Javier; Carné‐Sánchez, Arnau; Maspoch, Daniel
- Advanced Materials, Vol. 31, Issue 21
Biohybrid Design Gets Personal: New Materials for Patient‐Specific Therapy
journal, July 2019
- Raman, Ritu; Langer, Robert
- Advanced Materials
3D‐Printed Gastric Resident Electronics
journal, December 2018
- Kong, Yong Lin; Zou, Xingyu; McCandler, Caitlin A.
- Advanced Materials Technologies, Vol. 4, Issue 3
Hydrogels as Emerging Materials for Translational Biomedicine
journal, October 2018
- Xue, Kun; Wang, Xiaoyuan; Yong, Pei Wern
- Advanced Therapeutics, Vol. 2, Issue 1
A Proresolving Peptide Nanotherapy for Site‐Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota
journal, July 2019
- Li, Chenwen; Zhao, Yang; Cheng, Juan
- Advanced Science, Vol. 6, Issue 18
Materialien und Strukturen für schluckbare elektromechanische medizinische Funktionseinheiten
journal, October 2018
- Bettinger, Christopher J.
- Angewandte Chemie, Vol. 130, Issue 52
Supramolecular Interfacial Polymerization: A Controllable Method of Fabricating Supramolecular Polymeric Materials
journal, May 2017
- Qin, Bo; Zhang, Shuai; Song, Qiao
- Angewandte Chemie International Edition, Vol. 56, Issue 26
Advances in Materials and Structures for Ingestible Electromechanical Medical Devices
journal, October 2018
- Bettinger, Christopher J.
- Angewandte Chemie International Edition, Vol. 57, Issue 52
Drawing with Iron on a Gel Containing a Supramolecular Siderophore
journal, November 2019
- Xiao, Songjun; Paukstelis, Paul J.; Ash, Richard D.
- Angewandte Chemie International Edition, Vol. 58, Issue 51
Impact of the aluminum sulfate 18‐hydrate particle size on the coordination crosslinking behaviors of acrylonitrile–butadiene rubber–aluminum sulfate 18‐hydrate composites
journal, May 2019
- Cao, Changlin; Cai, Congyu; Wang, Yangtao
- Journal of Applied Polymer Science, Vol. 136, Issue 36
Gel Formed by Self‐Assembly of a Urea‐Modified Monopyrrolotetrathiafulvalene Derivative Displays Multi‐Stimuli Responsiveness and Absorption of Rhodamine B
journal, October 2018
- Liu, Yucun; Liu, Lihui; Zhu, Enwei
- ChemPlusChem, Vol. 83, Issue 12
A pH-Responsive Hydrogel Based on a Tumor-Targeting Mesoporous Silica Nanocomposite for Sustained Cancer Labeling and Therapy
journal, July 2016
- Chen, Xin; Liu, Zhongning
- Macromolecular Rapid Communications, Vol. 37, Issue 18
Supramolecular Polymerization from Controllable Fabrication to Living Polymerization
journal, July 2017
- Huang, Zehuan; Qin, Bo; Chen, Linghui
- Macromolecular Rapid Communications, Vol. 38, Issue 17
Photoredox-Based Actuation of an Artificial Molecular Muscle
journal, January 2018
- Liles, Kevin P.; Greene, Angelique F.; Danielson, Mary K.
- Macromolecular Rapid Communications, Vol. 39, Issue 17
Dually Cross‐Linked Supramolecular Hydrogel as Surface Plasmon Resonance Sensor for Small Molecule Detection
journal, May 2019
- Li, Jie; Ji, Chendong; Yu, Xiaoqian
- Macromolecular Rapid Communications, Vol. 40, Issue 14
Mechano-Based Transductive Sensing for Wearable Healthcare
journal, January 2018
- Wang, Ting; Yang, Hui; Qi, Dianpeng
- Small, Vol. 14, Issue 11
pH-responsive nanosystems based on reduced graphene oxide grafted with polycaprolactone-block-poly(succinyloxyethylmethacrylate) for doxorubicin release
journal, April 2019
- Massoumi, Bakhshali; Sarvari, Raana; Khanizadeh, Leila
- Journal of the Iranian Chemical Society, Vol. 16, Issue 9
Designing hydrogels for controlled drug delivery
journal, October 2016
- Li, Jianyu; Mooney, David J.
- Nature Reviews Materials, Vol. 1, Issue 12
Bioresponsive materials
journal, October 2016
- Lu, Yue; Aimetti, Alex A.; Langer, Robert
- Nature Reviews Materials, Vol. 2, Issue 1
In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers
journal, March 2017
- Wang, Rui; Zhou, Lei; Wang, Wenxing
- Nature Communications, Vol. 8, Issue 1
Non-equilibrium dissipative supramolecular materials with a tunable lifetime
journal, July 2017
- Tena-Solsona, Marta; Rieß, Benedikt; Grötsch, Raphael K.
- Nature Communications, Vol. 8, Issue 1
Triggerable tough hydrogels for gastric resident dosage forms
journal, July 2017
- Liu, Jinyao; Pang, Yan; Zhang, Shiyi
- Nature Communications, Vol. 8, Issue 1
Bioinspired ultra-stretchable and anti-freezing conductive hydrogel fibers with ordered and reversible polymer chain alignment
journal, September 2018
- Zhao, Xue; Chen, Fang; Li, Yuanheng
- Nature Communications, Vol. 9, Issue 1
Ingestible hydrogel device
journal, January 2019
- Liu, Xinyue; Steiger, Christoph; Lin, Shaoting
- Nature Communications, Vol. 10, Issue 1
Self-regenerating giant hyaluronan polymer brushes
journal, December 2019
- Wei, Wenbin; Faubel, Jessica L.; Selvakumar, Hemaa
- Nature Communications, Vol. 10, Issue 1
Prolonged energy harvesting for ingestible devices
journal, February 2017
- Nadeau, Phillip; El-Damak, Dina; Glettig, Dean
- Nature Biomedical Engineering, Vol. 1, Issue 3
Robotically handled whole-tissue culture system for the screening of oral drug formulations
journal, April 2020
- von Erlach, Thomas; Saxton, Sarah; Shi, Yunhua
- Nature Biomedical Engineering, Vol. 4, Issue 5
Ingestible electronics for diagnostics and therapy
journal, December 2018
- Steiger, Christoph; Abramson, Alex; Nadeau, Phillip
- Nature Reviews Materials, Vol. 4, Issue 2
Scalable Gastric Resident Systems for Veterinary Application
journal, August 2018
- Hayward, Alison; Bensel, Taylor; Mazdiyasni, Hormoz
- Scientific Reports, Vol. 8, Issue 1
Supramolecular polymer networks: hydrogels and bulk materials
journal, January 2016
- Voorhaar, Lenny; Hoogenboom, Richard
- Chemical Society Reviews, Vol. 45, Issue 14
Insight into the local near-infrared photothermal dynamics of graphene oxide functionalized polymers through optical microfibers
journal, January 2018
- Huang, Yunyun; Chen, Chaoyan; Li, Hongtao
- Physical Chemistry Chemical Physics, Vol. 20, Issue 7
Phosphonium hydrogels for controlled release of ionic cargo
journal, January 2018
- Harrison, Tristan D.; Ragogna, Paul J.; Gillies, Elizabeth R.
- Chemical Communications, Vol. 54, Issue 79
Sticky ends in a self-assembling ABA triblock copolymer: the role of ureas in stimuli-responsive hydrogels
journal, January 2019
- Shafranek, Ryan T.; Leger, Joel D.; Zhang, Song
- Molecular Systems Design & Engineering, Vol. 4, Issue 1
DN strategy constructed photo-crosslinked PVA/CNC/P(NIPPAm- co -AA) hydrogels with temperature-sensitive and pH-sensitive properties
journal, January 2018
- Li, Zhangkang; Bai, Huiyu; Zhang, Shengwen
- New Journal of Chemistry, Vol. 42, Issue 16
Readily functionalized AAA–DDD triply hydrogen-bonded motifs
journal, January 2018
- Tong, Feng; Linares-Mendez, Iamnica J.; Han, Yi-Fei
- Organic & Biomolecular Chemistry, Vol. 16, Issue 16
A dual-responsive cross-linked supramolecular polymer network gel: hierarchical supramolecular self-assembly driven by pillararene-based molecular recognition and metal–ligand interactions
journal, January 2018
- Shao, Li; Yang, Jie; Hua, Bin
- Polymer Chemistry, Vol. 9, Issue 11
Biomimetic and bioinspired strategies for oral drug delivery
journal, January 2020
- Hu, Xiankang; Yang, Guoyu; Chen, Sheng
- Biomaterials Science, Vol. 8, Issue 4
Fluorescence lifetime imaging of upper gastrointestinal pH in vivo with a lanthanide based near-infrared τ probe
journal, January 2019
- Ning, Yingying; Cheng, Shengming; Wang, Jing-Xiang
- Chemical Science, Vol. 10, Issue 15
Drug delivery across length scales
journal, February 2018
- Delcassian, Derfogail; Patel, Asha K.; Cortinas, Abel B.
- Journal of Drug Targeting, Vol. 27, Issue 3
Changing the pill: developments toward the promise of an ultra-long-acting gastroretentive dosage form
journal, November 2018
- Altreuter, David H.; Kirtane, Ameya R.; Grant, Tyler
- Expert Opinion on Drug Delivery, Vol. 15, Issue 12
Treatment and prevention of HIV infection with long-acting antiretrovirals
journal, March 2018
- Benítez-Gutiérrez, Laura; Soriano, Vicente; Requena, Silvia
- Expert Review of Clinical Pharmacology, Vol. 11, Issue 5
Long-range, selective, on-demand suspension interactions: Combining and triggering soluto-inertial beacons
journal, August 2019
- Banerjee, Anirudha; Squires, Todd M.
- Science Advances, Vol. 5, Issue 8
Light-degradable hydrogels as dynamic triggers for gastrointestinal applications
journal, January 2020
- Raman, Ritu; Hua, Tiffany; Gwynne, Declan
- Science Advances, Vol. 6, Issue 3
Oral, ultra–long-lasting drug delivery: Application toward malaria elimination goals
journal, November 2016
- Bellinger, Andrew M.; Jafari, Mousa; Grant, Tyler M.
- Science Translational Medicine, Vol. 8, Issue 365
A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
journal, March 2019
- Verma, Malvika; Vishwanath, Karan; Eweje, Feyisope
- Science Translational Medicine, Vol. 11, Issue 483
Temperature-responsive biometamaterials for gastrointestinal applications
journal, April 2019
- Babaee, Sahab; Pajovic, Simo; Kirtane, Ameya R.
- Science Translational Medicine, Vol. 11, Issue 488
Continuous fabrication of near-infrared light responsive bilayer hydrogel fibers based on microfluidic spinning
journal, May 2019
- Zhou, Meiling; Gong, Jinghua; Ma, Jinghong
- e-Polymers, Vol. 19, Issue 1
Self-Healing Supramolecular Hydrogels Based on Reversible Physical Interactions
journal, April 2016
- Strandman, Satu; Zhu, X. X.
- Gels, Vol. 2, Issue 2
Synthesis and Characterization of pH and Thermo Dual-Responsive Hydrogels with a Semi-IPN Structure Based on N-Isopropylacrylamide and Itaconamic Acid
journal, April 2018
- Rwei, Syang-Peng; Tuan, Huynh; Chiang, Whe-Yi
- Materials, Vol. 11, Issue 5
Recent Development of pH-Responsive Polymers for Cancer Nanomedicine
journal, December 2018
- Tang, Houliang; Zhao, Weilong; Yu, Jinming
- Molecules, Vol. 24, Issue 1
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
journal, March 2019
- Homayun, Bahman; Lin, Xueting; Choi, Hyo-Jick
- Pharmaceutics, Vol. 11, Issue 3
Supramolecular Nanostructures Based on Cyclodextrin and Poly(ethylene oxide): Syntheses, Structural Characterizations and Applications for Drug Delivery
journal, May 2016
- Zheng, Yue; Wyman, Ian
- Polymers, Vol. 8, Issue 5
Novel pH/reduction responsive graphene oxide nanoparticles based hydrogel for targeted combination chemotherapy
text, January 2019
- Anirudhan, Thayyath Sreenivasan; Manasa, A. M.
- Taylor & Francis
Drawing with Iron on a Gel Containing a Supramolecular Siderophore
journal, November 2019
- Xiao, Songjun; Paukstelis, Paul J.; Ash, Richard D.
- Angewandte Chemie, Vol. 131, Issue 51
Functionalization-Directed Stabilization of Hydrogen-Bonded Polymer Complex Fibers: Elasticity and Conductivity
journal, July 2019
- Li, Jiefu; Sun, Jiaxing; Wu, Di
- Advanced Fiber Materials, Vol. 1, Issue 1
Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy
journal, January 2018
- Kirtane, Ameya R.; Abouzid, Omar; Minahan, Daniel
- Nature Communications, Vol. 9, Issue 1
Dual-responsive recurrent self-assembly of a supramolecular polymer based on the host–guest complexation interaction between β-cyclodextrin and azobenzene
journal, January 2018
- Shen, Ping; Qiu, Liyan
- New Journal of Chemistry, Vol. 42, Issue 5
pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms
journal, January 2017
- Liu, Lin; Yao, WenDong; Rao, YueFeng
- Drug Delivery, Vol. 24, Issue 1
Engineering Strategies for Oral Therapeutic Enzymes to Enhance Their Stability and Activity
collection, January 2019
- Lapuhs, Philipp; Fuhrmann, Gregor
- Universität des Saarlandes
Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine
journal, October 2018
- Hoque, Jiaul; Sangaj, Nivedita; Varghese, Shyni
- Macromolecular Bioscience, Vol. 19, Issue 1
Engineering Strategies for Oral Therapeutic Enzymes to Enhance Their Stability and Activity
book, January 2019
- Lapuhs, Philipp; Fuhrmann, Gregor
- Advances in Experimental Medicine and Biology
Novel pH/reduction responsive graphene oxide nanoparticles based hydrogel for targeted combination chemotherapy
journal, December 2019
- Anirudhan, Thayyath Sreenivasan; Manasa, A. M.
- International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 70, Issue 4
Designing Hydrogels for Controlled Drug Delivery
book, February 2020
- Trombino, Sonia; Cassano, Roberta
Novel pH/reduction responsive graphene oxide nanoparticles based hydrogel for targeted combination chemotherapy
text, January 2019
- Anirudhan, Thayyath Sreenivasan; Manasa, A. M.
- Taylor & Francis
Supramolecular Interfacial Polymerization: A Controllable Method of Fabricating Supramolecular Polymeric Materials
journal, May 2017
- Qin, Bo; Zhang, Shuai; Song, Qiao
- Angewandte Chemie, Vol. 129, Issue 26
Using zeta potential to study the ionisation behaviour of polymers employed in modified-release dosage forms and estimating their pKa
journal, December 2019
- Barbosa, Joao A. C.; Abdelsadig, Malaz S. E.; Conway, Barbara R.
- International Journal of Pharmaceutics: X, Vol. 1
Bioinspired ultra-stretchable and anti-freezing conductive hydrogel fibers with ordered and reversible polymer chain alignment
journal, September 2018
- Zhao, Xue; Chen, Fang; Li, Yuanheng
- Nature Communications, Vol. 9, Issue 1
Self-regenerating giant hyaluronan polymer brushes
journal, December 2019
- Wei, Wenbin; Faubel, Jessica L.; Selvakumar, Hemaa
- Nature Communications, Vol. 10, Issue 1
Self-Healing Supramolecular Hydrogels Based on Reversible Physical Interactions
journal, April 2016
- Strandman, Satu; Zhu, X. X.
- Gels, Vol. 2, Issue 2
Synthesis and Characterization of pH and Thermo Dual-Responsive Hydrogels with a Semi-IPN Structure Based on N-Isopropylacrylamide and Itaconamic Acid
journal, April 2018
- Rwei, Syang-Peng; Tuan, Huynh; Chiang, Whe-Yi
- Materials, Vol. 11, Issue 5
Recent Development of pH-Responsive Polymers for Cancer Nanomedicine
journal, December 2018
- Tang, Houliang; Zhao, Weilong; Yu, Jinming
- Molecules, Vol. 24, Issue 1
Supramolecular Nanostructures Based on Cyclodextrin and Poly(ethylene oxide): Syntheses, Structural Characterizations and Applications for Drug Delivery
journal, May 2016
- Zheng, Yue; Wyman, Ian
- Polymers, Vol. 8, Issue 5