Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering
Abstract
In this paper, we review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by the sometimes conflicting results found in the literature, even in the case of the most studied lipid bilayers. Increasingly, accurate and detailed structural models require more experimental data, such as those from contrast varied neutron scattering and X-ray scattering experiments that are jointly refined with molecular dynamics simulations. This experimental and computational approach produces robust bilayer structural parameters that enable insights, for example, into the interplay between collective membrane properties and its components (e.g., hydrocarbon chain length and unsaturation, and lipid headgroup composition). Finally, from model studies such as these, one is better able to appreciate how a real biological membrane can be tuned by balancing the contributions from the lipid’s different moieties (e.g., acyl chains, headgroups, backbones, etc.).
- Authors:
-
- Joint Inst. for Nuclear Research (JINR), Dubna (Russian Federation). Frank Lab. of Neutron Physics; Comenius Univ., Bratislava (Slovakia). Dept. of Physical Chemistry of Drugs
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences
- Univ. of South Florida, Tampa, FL (United States). Dept. of Physics
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences; Univ. of Tennessee, Knoxville, TN (United States). Dept. of Physics and Astronomy
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); Ministry of Education, Science, Research and Sport of the Slovak Republic (Slovakia); Joint Inst. for Nuclear Research (JINR) (Russian Federation)
- OSTI Identifier:
- 1265608
- Grant/Contract Number:
- AC05-00OR22725; 1/1224/12; 04-4-1121-2015/2017
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Membranes
- Additional Journal Information:
- Journal Volume: 5; Journal Issue: 3; Journal ID: ISSN 2077-0375
- Publisher:
- MDPI
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; lipidome; bilayer; structure; X-ray scattering; neutron scattering; lipid area
Citation Formats
Kučerka, Norbert, Heberle, Frederick A., Pan, Jianjun, and Katsaras, John. Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering. United States: N. p., 2015.
Web. doi:10.3390/membranes5030454.
Kučerka, Norbert, Heberle, Frederick A., Pan, Jianjun, & Katsaras, John. Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering. United States. https://doi.org/10.3390/membranes5030454
Kučerka, Norbert, Heberle, Frederick A., Pan, Jianjun, and Katsaras, John. Mon .
"Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering". United States. https://doi.org/10.3390/membranes5030454. https://www.osti.gov/servlets/purl/1265608.
@article{osti_1265608,
title = {Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering},
author = {Kučerka, Norbert and Heberle, Frederick A. and Pan, Jianjun and Katsaras, John},
abstractNote = {In this paper, we review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by the sometimes conflicting results found in the literature, even in the case of the most studied lipid bilayers. Increasingly, accurate and detailed structural models require more experimental data, such as those from contrast varied neutron scattering and X-ray scattering experiments that are jointly refined with molecular dynamics simulations. This experimental and computational approach produces robust bilayer structural parameters that enable insights, for example, into the interplay between collective membrane properties and its components (e.g., hydrocarbon chain length and unsaturation, and lipid headgroup composition). Finally, from model studies such as these, one is better able to appreciate how a real biological membrane can be tuned by balancing the contributions from the lipid’s different moieties (e.g., acyl chains, headgroups, backbones, etc.).},
doi = {10.3390/membranes5030454},
journal = {Membranes},
number = 3,
volume = 5,
place = {United States},
year = {Mon Sep 21 00:00:00 EDT 2015},
month = {Mon Sep 21 00:00:00 EDT 2015}
}
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