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Title: On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons

In order to understand the biological role of lipids in cell membranes, it is necessary to determine the mesoscopic structure of well-defined model membrane systems. Neutron and X-ray scattering are non-invasive, probe-free techniques that have been used extensively in such systems to probe length scales ranging from angstroms to microns, and dynamics occurring over picosecond to millisecond time scales. Finally, recent developments in the area of phase separated lipid systems mimicking membrane rafts will be presented, and the underlying concepts of the different scattering techniques used to study them will be discussed in detail.
Authors:
 [1] ;  [2] ;  [3] ;  [1] ;  [4]
  1. Univ. of Graz (Austria). Inst. of Molecular Biosciences. Biophysics Division; BioTechMed-Graz, Graz (Austria)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences; Univ. of Tennessee, Knoxville, TN (United States). Bredesen Center for Interdisciplinary Research and Graduate Education
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences; Univ. of Tennessee, Knoxville, TN (United States). Dept. of Physics
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences; Univ. of Tennessee, Knoxville, TN (United States). Dept. of Physics; Brock Univ., St. Catharines (Canada). Dept. of Physics; Univ. of Tennessee, Knoxville, TN (United States). Bredesen Center for Interdisciplinary Research and Graduate Education
Publication Date:
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Soft Matter
Additional Journal Information:
Journal Volume: 11; Journal Issue: 47; Journal ID: ISSN 1744-683X
Publisher:
Royal Society of Chemistry
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); Austrian Science Fund (FWF)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 47 OTHER INSTRUMENTATION; Neutron Scattering; Biomembranes
OSTI Identifier:
1265606

Marquardt, Drew, Heberle, Frederick A., Nickels, Jonathan D., Pabst, Georg, and Katsaras, John. On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons. United States: N. p., Web. doi:10.1039/C5SM01807B.
Marquardt, Drew, Heberle, Frederick A., Nickels, Jonathan D., Pabst, Georg, & Katsaras, John. On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons. United States. doi:10.1039/C5SM01807B.
Marquardt, Drew, Heberle, Frederick A., Nickels, Jonathan D., Pabst, Georg, and Katsaras, John. 2015. "On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons". United States. doi:10.1039/C5SM01807B. https://www.osti.gov/servlets/purl/1265606.
@article{osti_1265606,
title = {On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons},
author = {Marquardt, Drew and Heberle, Frederick A. and Nickels, Jonathan D. and Pabst, Georg and Katsaras, John},
abstractNote = {In order to understand the biological role of lipids in cell membranes, it is necessary to determine the mesoscopic structure of well-defined model membrane systems. Neutron and X-ray scattering are non-invasive, probe-free techniques that have been used extensively in such systems to probe length scales ranging from angstroms to microns, and dynamics occurring over picosecond to millisecond time scales. Finally, recent developments in the area of phase separated lipid systems mimicking membrane rafts will be presented, and the underlying concepts of the different scattering techniques used to study them will be discussed in detail.},
doi = {10.1039/C5SM01807B},
journal = {Soft Matter},
number = 47,
volume = 11,
place = {United States},
year = {2015},
month = {9}
}