Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?
Abstract
Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from 239PuO2 inhalation, as a prophylaxis against lung cancer.
- Authors:
-
- Cuttler & Associates, Vaughan, ON (Canada)
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Publication Date:
- Research Org.:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1263484
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Dose-Response
- Additional Journal Information:
- Journal Volume: 13; Journal Issue: -1; Journal ID: ISSN 1559-3258
- Publisher:
- International Hormesis Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; plutonium-dioxide; inhalation; lung cancer; prophylaxis; radiation hormesis; adaptive protection
Citation Formats
Cuttler, Jerry M., and Feinendegen, Ludwig E. Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?. United States: N. p., 2015.
Web. doi:10.2203/dose-response.15-003.Cuttler.
Cuttler, Jerry M., & Feinendegen, Ludwig E. Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?. United States. https://doi.org/10.2203/dose-response.15-003.Cuttler
Cuttler, Jerry M., and Feinendegen, Ludwig E. Thu .
"Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?". United States. https://doi.org/10.2203/dose-response.15-003.Cuttler. https://www.osti.gov/servlets/purl/1263484.
@article{osti_1263484,
title = {Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?},
author = {Cuttler, Jerry M. and Feinendegen, Ludwig E.},
abstractNote = {Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from 239PuO2 inhalation, as a prophylaxis against lung cancer.},
doi = {10.2203/dose-response.15-003.Cuttler},
journal = {Dose-Response},
number = -1,
volume = 13,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 2015},
month = {Thu Jan 01 00:00:00 EST 2015}
}
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Works referencing / citing this record:
Meta-analysis of thirty-two case–control and two ecological radon studies of lung cancer
journal, November 2017
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