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Title: Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature

Abstract

During routine pharmaceutical development and scale-up work, severe corrosion of a Hastelloy Alloy C-22 filter dryer was observed after single, short (several hours) contact with the product slurry at room temperature. Initial investigations showed that the presence of both 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and HCl was sufficient in an acetonitrile solution to cause rapid corrosion of C-22. More detailed mass loss studies showed initial corrosion rates exceeding25 mm/year that then decreased over several hours to steady state rates of 3-5 mm/year. The corrosion was highly uniform. Electrochemical measurements demonstrated that although C-22 is spontaneously passive in acetonitrile solution, the presence of HCl leads to the development of a transpassive region. Furthermore, DDQ is a sufficiently strong oxidizer, particularly in acidic solutions, to polarize the C-22 well into the transpassive region, leading to the observed high corrosion rates.

Authors:
 [1];  [2];  [2];  [3]
  1. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  2. Teva Branded Pharmaceuticals, Malvern, PA (United States)
  3. Univ. of Virginia, Charlottesville, VA (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1259672
Report Number(s):
SAND-2016-2348J
Journal ID: ISSN 0010-9312; 621995
Grant/Contract Number:  
AC04-94AL85000
Resource Type:
Accepted Manuscript
Journal Name:
Corrosion
Additional Journal Information:
Journal Name: Corrosion; Journal ID: ISSN 0010-9312
Publisher:
NACE International
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; hastelloy C22; nickel; chromium; molybdenum; transpassivity; alloy 22; organic solvent; non-aqueous; hydrochloric acid; quinone

Citation Formats

Schindelholz, Eric J., Christie, Michael A., Allwein, Shawn P., and Kelly, Robert G. Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature. United States: N. p., 2016. Web. doi:10.5006/2081.
Schindelholz, Eric J., Christie, Michael A., Allwein, Shawn P., & Kelly, Robert G. Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature. United States. doi:10.5006/2081.
Schindelholz, Eric J., Christie, Michael A., Allwein, Shawn P., and Kelly, Robert G. Tue . "Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature". United States. doi:10.5006/2081. https://www.osti.gov/servlets/purl/1259672.
@article{osti_1259672,
title = {Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature},
author = {Schindelholz, Eric J. and Christie, Michael A. and Allwein, Shawn P. and Kelly, Robert G.},
abstractNote = {During routine pharmaceutical development and scale-up work, severe corrosion of a Hastelloy Alloy C-22 filter dryer was observed after single, short (several hours) contact with the product slurry at room temperature. Initial investigations showed that the presence of both 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and HCl was sufficient in an acetonitrile solution to cause rapid corrosion of C-22. More detailed mass loss studies showed initial corrosion rates exceeding25 mm/year that then decreased over several hours to steady state rates of 3-5 mm/year. The corrosion was highly uniform. Electrochemical measurements demonstrated that although C-22 is spontaneously passive in acetonitrile solution, the presence of HCl leads to the development of a transpassive region. Furthermore, DDQ is a sufficiently strong oxidizer, particularly in acidic solutions, to polarize the C-22 well into the transpassive region, leading to the observed high corrosion rates.},
doi = {10.5006/2081},
journal = {Corrosion},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {6}
}

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