Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature

Schindelholz, Eric J.; Christie, Michael A.; Allwein, Shawn P.; Kelly, Robert G.

doi:10.5006/2081

Title: Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature

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Abstract

During routine pharmaceutical development and scale-up work, severe corrosion of a Hastelloy Alloy C-22 filter dryer was observed after single, short (several hours) contact with the product slurry at room temperature. Initial investigations showed that the presence of both 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and HCl was sufficient in an acetonitrile solution to cause rapid corrosion of C-22. More detailed mass loss studies showed initial corrosion rates exceeding25 mm/year that then decreased over several hours to steady state rates of 3-5 mm/year. The corrosion was highly uniform. Electrochemical measurements demonstrated that although C-22 is spontaneously passive in acetonitrile solution, the presence of HCl leads to the development of a transpassive region. Furthermore, DDQ is a sufficiently strong oxidizer, particularly in acidic solutions, to polarize the C-22 well into the transpassive region, leading to the observed high corrosion rates.

Authors:

Schindelholz, Eric J. ^[1]; Christie, Michael A. ^[2]; Allwein, Shawn P. ^[2]; Kelly, Robert G. ^[3]

Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Teva Branded Pharmaceuticals, Malvern, PA (United States)
Univ. of Virginia, Charlottesville, VA (United States)

Publication Date:: Tue Jun 21 00:00:00 EDT 2016

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE National Nuclear Security Administration (NNSA)

OSTI Identifier:: 1259672

Report Number(s):: SAND-2016-2348J
Journal ID: ISSN 0010-9312; 621995

Grant/Contract Number:: AC04-94AL85000

Resource Type:: Accepted Manuscript

Journal Name:: Corrosion

Additional Journal Information:: Journal Name: Corrosion; Journal ID: ISSN 0010-9312

Publisher:: NACE International

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE; hastelloy C22; nickel; chromium; molybdenum; transpassivity; alloy 22; organic solvent; non-aqueous; hydrochloric acid; quinone

Citation Formats


                    Schindelholz, Eric J., Christie, Michael A., Allwein, Shawn P., and Kelly, Robert G. Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature.  United States: N. p., 2016. 
Web.  doi:10.5006/2081.

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                    Schindelholz, Eric J., Christie, Michael A., Allwein, Shawn P., & Kelly, Robert G. Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature.  United States.  https://doi.org/10.5006/2081

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                    Schindelholz, Eric J., Christie, Michael A., Allwein, Shawn P., and Kelly, Robert G. Tue .  
"Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature".  United States.  https://doi.org/10.5006/2081.  https://www.osti.gov/servlets/purl/1259672.

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@article{osti_1259672,

  title        = {Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature},

  author       = {Schindelholz, Eric J. and Christie, Michael A. and Allwein, Shawn P. and Kelly, Robert G.},

  abstractNote = {During routine pharmaceutical development and scale-up work, severe corrosion of a Hastelloy Alloy C-22 filter dryer was observed after single, short (several hours) contact with the product slurry at room temperature. Initial investigations showed that the presence of both 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and HCl was sufficient in an acetonitrile solution to cause rapid corrosion of C-22. More detailed mass loss studies showed initial corrosion rates exceeding25 mm/year that then decreased over several hours to steady state rates of 3-5 mm/year. The corrosion was highly uniform. Electrochemical measurements demonstrated that although C-22 is spontaneously passive in acetonitrile solution, the presence of HCl leads to the development of a transpassive region. Furthermore, DDQ is a sufficiently strong oxidizer, particularly in acidic solutions, to polarize the C-22 well into the transpassive region, leading to the observed high corrosion rates.},

  doi          = {10.5006/2081},

  journal      = {Corrosion},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jun 21 00:00:00 EDT 2016},

  month        = {Tue Jun 21 00:00:00 EDT 2016}

}

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