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Title: An embryo of protocells: The capsule of graphene with selective ion channels

In this study, the synthesis of artificial cell is a route for searching the origin of protocell. Here, we create a novel cell model of graphene capsules with selective ion channels, indicating that graphene might be an embryo of protocell membrane. Firstly, we found that the highly oxidized graphene and phospholipid-graphene oxide composite would curl into capsules under a strongly acidic saturated solution of heavy metallic salt solution at low temperature. Secondly, L-amino acids exhibited higher reactivity than D-amino acids on graphene oxides to form peptides, and the formed peptides in the influence of graphene would be transformed into a secondary structure, promoting the formation of left-handed proteins. Lastly, monolayer nanoporous graphene, prepared by unfocused 84Kr 25+, has a high selectivity for permeation of the monovalent metal ions ( Rb + > K + > Cs + > Na + > Li +, based on permeation concentration), but does not allow Cl- go through. It is similar to K+ channels, which would cause an influx of K + into capsule of graphene with the increase of pH in the primitive ocean, creating a suitable inner condition for the origin of life. Therefore, we built a model cell of graphene, whichmore » would provide a route for reproducing the origin of life.« less
 [1] ;  [2] ;  [3] ;  [1] ;  [1] ;  [4] ;  [1] ;  [1] ;  [3] ;  [3] ;  [3] ;  [5] ;  [1] ;  [3] ;  [1] ;  [1] ;  [3] ;  [2] ;  [3]
  1. Chinese Academy of Sciences, Lanzhou (People's Republic of China)
  2. Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou (People's Republic of China)
  3. Lanzhou Univ., Lanzhou (People's Republic of China)
  4. Fudan Univ., Shanghai (People's Republic of China); Lanzhou Univ., Lanzhou (People's Republic of China)
  5. Brookhaven National Lab. (BNL), Upton, NY (United States)
Publication Date:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 5; Journal ID: ISSN 2045-2322
Nature Publishing Group
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
Country of Publication:
United States
59 BASIC BIOLOGICAL SCIENCES; biomaterials-cells; chemical biology; chemical origin of life
OSTI Identifier: