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Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication and pathogenesis in the past decade. Here we review the most recent molecular advances in CCHFV-related research, and provide perspectives on future research.

Authors:
 [1];  [1];  [1];  [1];  [1]
  1. Centers for Disease Control and Prevention, Atlanta, GA (United States). Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology
Publication Date:
Research Org.:
Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States); Centers for Disease Control and Prevention, Atlanta, GA (United States). Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology
Sponsoring Org.:
USDOE; Centers for Disease Control and Prevention
OSTI Identifier:
1258588
Resource Type:
Accepted Manuscript
Journal Name:
Viruses
Additional Journal Information:
Journal Volume: 8; Journal Issue: 4; Journal ID: ISSN 1999-4915
Publisher:
MDPI
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Crimean-Congo hemorrhagic fever; viral hemorrhagic fever; reverse genetics; pathogenesis; tick-borne virus

Citation Formats

Zivcec, Marko, Scholte, Florine, Spiropoulou, Christina, Spengler, Jessica, and Bergeron, Éric. Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. United States: N. p., 2016. Web. doi:10.3390/v8040106.
Zivcec, Marko, Scholte, Florine, Spiropoulou, Christina, Spengler, Jessica, & Bergeron, Éric. Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. United States. doi:10.3390/v8040106.
Zivcec, Marko, Scholte, Florine, Spiropoulou, Christina, Spengler, Jessica, and Bergeron, Éric. Thu . "Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus". United States. doi:10.3390/v8040106. https://www.osti.gov/servlets/purl/1258588.
@article{osti_1258588,
title = {Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus},
author = {Zivcec, Marko and Scholte, Florine and Spiropoulou, Christina and Spengler, Jessica and Bergeron, Éric},
abstractNote = {Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication and pathogenesis in the past decade. Here we review the most recent molecular advances in CCHFV-related research, and provide perspectives on future research.},
doi = {10.3390/v8040106},
journal = {Viruses},
number = 4,
volume = 8,
place = {United States},
year = {2016},
month = {4}
}

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Cited by: 4 works
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  • Kortekaas, Jeroen; Vloet, Rianka P. M.; McAuley, Alexander J.
  • Vector-Borne and Zoonotic Diseases, Vol. 15, Issue 12
  • DOI: 10.1089/vbz.2015.1855

Immunization of Knock-Out α/β Interferon Receptor Mice against High Lethal Dose of Crimean-Congo Hemorrhagic Fever Virus with a Cell Culture Based Vaccine
journal, March 2015


A Novel Vaccine against Crimean-Congo Haemorrhagic Fever Protects 100% of Animals against Lethal Challenge in a Mouse Model
journal, March 2014


Type I interferon inhibits Crimean-Congo hemorrhagic fever virus in human target cells
journal, January 2005

  • Andersson, Ida; Lundkvist, Åke; Haller, Otto
  • Journal of Medical Virology, Vol. 78, Issue 2
  • DOI: 10.1002/jmv.20530

    Works referencing / citing this record:

    Tick-Borne Viruses
    journal, February 2018


    The DEVD motif of Crimean-Congo hemorrhagic fever virus nucleoprotein is essential for viral replication in tick cells
    journal, December 2018

    • Salata, Cristiano; Monteil, Vanessa; Karlberg, Helen
    • Emerging Microbes & Infections, Vol. 7, Issue 1
    • DOI: 10.1038/s41426-018-0192-0

    Tick-Borne Viruses
    journal, February 2018