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Title: Performance of the Tachyon Time-of-Flight PET Camera

Abstract

We have constructed and characterized a time-of-flight Positron Emission Tomography (TOF PET) camera called the Tachyon. The Tachyon is a single-ring Lutetium Oxyorthosilicate (LSO) based camera designed to obtain significantly better timing resolution than the ~ 550 ps found in present commercial TOF cameras, in order to quantify the benefit of improved TOF resolution for clinically relevant tasks. The Tachyon's detector module is optimized for timing by coupling the 6.15 ×25 mm 2 side of 6.15 ×6.15 ×25 mm 3 LSO scintillator crystals onto a 1-inch diameter Hamamatsu R-9800 PMT with a super-bialkali photocathode. We characterized the camera according to the NEMA NU 2-2012 standard, measuring the energy resolution, timing resolution, spatial resolution, noise equivalent count rates and sensitivity. The Tachyon achieved a coincidence timing resolution of 314 ps +/- 20 ps FWHM over all crystal-crystal combinations. Experiments were performed with the NEMA body phantom to assess the imaging performance improvement over non-TOF PET. We find that the results show that at a matched contrast, incorporating 314 ps TOF reduces the standard deviation of the contrast by a factor of about 2.3.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [1];  [2];  [2];  [1]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  2. Univ. of California, Davis, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1257993
Grant/Contract Number:  
AC02- 05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
IEEE Transactions on Nuclear Science
Additional Journal Information:
Journal Volume: 62; Journal Issue: 1; Journal ID: ISSN 0018-9499
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Peng, Q., Choong, W. -S., Vu, C., Huber, J. S., Janecek, M., Wilson, D., Huesman, R. H., Qi, Jinyi, Zhou, Jian, and Moses, W. W. Performance of the Tachyon Time-of-Flight PET Camera. United States: N. p., 2015. Web. doi:10.1109/tns.2014.2375176.
Peng, Q., Choong, W. -S., Vu, C., Huber, J. S., Janecek, M., Wilson, D., Huesman, R. H., Qi, Jinyi, Zhou, Jian, & Moses, W. W. Performance of the Tachyon Time-of-Flight PET Camera. United States. doi:10.1109/tns.2014.2375176.
Peng, Q., Choong, W. -S., Vu, C., Huber, J. S., Janecek, M., Wilson, D., Huesman, R. H., Qi, Jinyi, Zhou, Jian, and Moses, W. W. Fri . "Performance of the Tachyon Time-of-Flight PET Camera". United States. doi:10.1109/tns.2014.2375176. https://www.osti.gov/servlets/purl/1257993.
@article{osti_1257993,
title = {Performance of the Tachyon Time-of-Flight PET Camera},
author = {Peng, Q. and Choong, W. -S. and Vu, C. and Huber, J. S. and Janecek, M. and Wilson, D. and Huesman, R. H. and Qi, Jinyi and Zhou, Jian and Moses, W. W.},
abstractNote = {We have constructed and characterized a time-of-flight Positron Emission Tomography (TOF PET) camera called the Tachyon. The Tachyon is a single-ring Lutetium Oxyorthosilicate (LSO) based camera designed to obtain significantly better timing resolution than the ~ 550 ps found in present commercial TOF cameras, in order to quantify the benefit of improved TOF resolution for clinically relevant tasks. The Tachyon's detector module is optimized for timing by coupling the 6.15 ×25 mm2 side of 6.15 ×6.15 ×25 mm3 LSO scintillator crystals onto a 1-inch diameter Hamamatsu R-9800 PMT with a super-bialkali photocathode. We characterized the camera according to the NEMA NU 2-2012 standard, measuring the energy resolution, timing resolution, spatial resolution, noise equivalent count rates and sensitivity. The Tachyon achieved a coincidence timing resolution of 314 ps +/- 20 ps FWHM over all crystal-crystal combinations. Experiments were performed with the NEMA body phantom to assess the imaging performance improvement over non-TOF PET. We find that the results show that at a matched contrast, incorporating 314 ps TOF reduces the standard deviation of the contrast by a factor of about 2.3.},
doi = {10.1109/tns.2014.2375176},
journal = {IEEE Transactions on Nuclear Science},
number = 1,
volume = 62,
place = {United States},
year = {2015},
month = {1}
}

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