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Title: Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse

Abstract

Understanding x-ray radiation damage is a crucial issue for both medical applications of x rays and x-ray free-electron-laser (XFEL) science aimed at molecular imaging. Decrypting the charge and fragmentation dynamics of nucleobases, the smallest units of a macro-biomolecule, contributes to a bottom-up understanding of the damage via cascades of phenomena following x-ray exposure. We investigate experimentally and by numerical simulations the ultrafast radiation damage induced on a nucleobase analogue (5-iodouracil) by an ultrashort (10 fs) high-intensity radiation pulse generated by XFEL at SPring-8 Angstrom Compact free electron Laser (SACLA). The present study elucidates a plausible underlying radiosensitizing mechanism of 5-iodouracil. This mechanism is independent of the exact composition of 5-iodouracil and thus relevant to other such radiosensitizers. Furthermore, we found that despite a rapid increase of the net molecular charge in the presence of iodine, and of the ultrafast release of hydrogen, the other atoms are almost frozen within the 10-fs duration of the exposure. Finally, this validates single-shot molecular imaging as a consistent approach, provided the radiation pulse used is brief enough.

Authors:
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Publication Date:
Research Org.:
Kansas State Univ., Manhattan, KS (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1257647
Alternate Identifier(s):
OSTI ID: 1286132
Grant/Contract Number:  
FG02-86ER1349; FG02-86ER13491
Resource Type:
Published Article
Journal Name:
Physical Review. X
Additional Journal Information:
Journal Name: Physical Review. X Journal Volume: 6 Journal Issue: 2; Journal ID: ISSN 2160-3308
Publisher:
American Physical Society
Country of Publication:
United States
Language:
English
Subject:
73 NUCLEAR PHYSICS AND RADIATION PHYSICS; ionization; charge; molecules; operation; region; atoms

Citation Formats

Nagaya, K., Motomura, K., Kukk, E., Fukuzawa, H., Wada, S., Tachibana, T., Ito, Y., Mondal, S., Sakai, T., Matsunami, K., Koga, R., Ohmura, S., Takahashi, Y., Kanno, M., Rudenko, A., Nicolas, C., Liu, X. -J., Zhang, Y., Chen, J., Anand, M., Jiang, Y. H., Kim, D. -E., Tono, K., Yabashi, M., Kono, H., Miron, C., Yao, M., and Ueda, K. Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse. United States: N. p., 2016. Web. https://doi.org/10.1103/PhysRevX.6.021035.
Nagaya, K., Motomura, K., Kukk, E., Fukuzawa, H., Wada, S., Tachibana, T., Ito, Y., Mondal, S., Sakai, T., Matsunami, K., Koga, R., Ohmura, S., Takahashi, Y., Kanno, M., Rudenko, A., Nicolas, C., Liu, X. -J., Zhang, Y., Chen, J., Anand, M., Jiang, Y. H., Kim, D. -E., Tono, K., Yabashi, M., Kono, H., Miron, C., Yao, M., & Ueda, K. Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse. United States. https://doi.org/10.1103/PhysRevX.6.021035
Nagaya, K., Motomura, K., Kukk, E., Fukuzawa, H., Wada, S., Tachibana, T., Ito, Y., Mondal, S., Sakai, T., Matsunami, K., Koga, R., Ohmura, S., Takahashi, Y., Kanno, M., Rudenko, A., Nicolas, C., Liu, X. -J., Zhang, Y., Chen, J., Anand, M., Jiang, Y. H., Kim, D. -E., Tono, K., Yabashi, M., Kono, H., Miron, C., Yao, M., and Ueda, K. Thu . "Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse". United States. https://doi.org/10.1103/PhysRevX.6.021035.
@article{osti_1257647,
title = {Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse},
author = {Nagaya, K. and Motomura, K. and Kukk, E. and Fukuzawa, H. and Wada, S. and Tachibana, T. and Ito, Y. and Mondal, S. and Sakai, T. and Matsunami, K. and Koga, R. and Ohmura, S. and Takahashi, Y. and Kanno, M. and Rudenko, A. and Nicolas, C. and Liu, X. -J. and Zhang, Y. and Chen, J. and Anand, M. and Jiang, Y. H. and Kim, D. -E. and Tono, K. and Yabashi, M. and Kono, H. and Miron, C. and Yao, M. and Ueda, K.},
abstractNote = {Understanding x-ray radiation damage is a crucial issue for both medical applications of x rays and x-ray free-electron-laser (XFEL) science aimed at molecular imaging. Decrypting the charge and fragmentation dynamics of nucleobases, the smallest units of a macro-biomolecule, contributes to a bottom-up understanding of the damage via cascades of phenomena following x-ray exposure. We investigate experimentally and by numerical simulations the ultrafast radiation damage induced on a nucleobase analogue (5-iodouracil) by an ultrashort (10 fs) high-intensity radiation pulse generated by XFEL at SPring-8 Angstrom Compact free electron Laser (SACLA). The present study elucidates a plausible underlying radiosensitizing mechanism of 5-iodouracil. This mechanism is independent of the exact composition of 5-iodouracil and thus relevant to other such radiosensitizers. Furthermore, we found that despite a rapid increase of the net molecular charge in the presence of iodine, and of the ultrafast release of hydrogen, the other atoms are almost frozen within the 10-fs duration of the exposure. Finally, this validates single-shot molecular imaging as a consistent approach, provided the radiation pulse used is brief enough.},
doi = {10.1103/PhysRevX.6.021035},
journal = {Physical Review. X},
number = 2,
volume = 6,
place = {United States},
year = {2016},
month = {6}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1103/PhysRevX.6.021035

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Cited by: 9 works
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