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Title: Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

We report that wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Sampling human sweat, which is rich in physiological information13, could enable non-invasive monitoring. Previously reported sweat-based and other noninvasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state14–18. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Lastly, our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plasticbased sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.
Authors:
 [1] ;  [1] ;  [1] ;  [2] ;  [1] ;  [3] ;  [1] ;  [1] ;  [1] ;  [1] ;  [4] ;  [3] ;  [2] ;  [4]
  1. Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
  2. Stanford Shool of Medicine, Palo Alto, CA (United States). Stanford Genome Center
  3. Univ. of California, Berkeley, CA (United States)
  4. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Publication Date:
Grant/Contract Number:
AC02-05CH11231
Type:
Accepted Manuscript
Journal Name:
Nature (London)
Additional Journal Information:
Journal Name: Nature (London); Journal Volume: 529; Journal Issue: 7587; Journal ID: ISSN 0028-0836
Publisher:
Nature Publishing Group
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; electrical and electronic engineering; materials for devices; techniques and instrumentation; health care
OSTI Identifier:
1252977
Alternate Identifier(s):
OSTI ID: 1414743

Gao, Wei, Emaminejad, Sam, Nyein, Hnin Yin Yin, Challa, Samyuktha, Chen, Kevin, Peck, Austin, Fahad, Hossain M., Ota, Hiroki, Shiraki, Hiroshi, Kiriya, Daisuke, Lien, Der-Hsien, Brooks, George A., Davis, Ronald W., and Javey, Ali. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. United States: N. p., Web. doi:10.1038/nature16521.
Gao, Wei, Emaminejad, Sam, Nyein, Hnin Yin Yin, Challa, Samyuktha, Chen, Kevin, Peck, Austin, Fahad, Hossain M., Ota, Hiroki, Shiraki, Hiroshi, Kiriya, Daisuke, Lien, Der-Hsien, Brooks, George A., Davis, Ronald W., & Javey, Ali. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. United States. doi:10.1038/nature16521.
Gao, Wei, Emaminejad, Sam, Nyein, Hnin Yin Yin, Challa, Samyuktha, Chen, Kevin, Peck, Austin, Fahad, Hossain M., Ota, Hiroki, Shiraki, Hiroshi, Kiriya, Daisuke, Lien, Der-Hsien, Brooks, George A., Davis, Ronald W., and Javey, Ali. 2016. "Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis". United States. doi:10.1038/nature16521. https://www.osti.gov/servlets/purl/1252977.
@article{osti_1252977,
title = {Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis},
author = {Gao, Wei and Emaminejad, Sam and Nyein, Hnin Yin Yin and Challa, Samyuktha and Chen, Kevin and Peck, Austin and Fahad, Hossain M. and Ota, Hiroki and Shiraki, Hiroshi and Kiriya, Daisuke and Lien, Der-Hsien and Brooks, George A. and Davis, Ronald W. and Javey, Ali},
abstractNote = {We report that wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Sampling human sweat, which is rich in physiological information13, could enable non-invasive monitoring. Previously reported sweat-based and other noninvasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state14–18. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Lastly, our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plasticbased sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.},
doi = {10.1038/nature16521},
journal = {Nature (London)},
number = 7587,
volume = 529,
place = {United States},
year = {2016},
month = {1}
}

Works referenced in this record:

A flexible and wearable glucose sensor based on functional polymers with Soft-MEMS techniques
journal, October 2006
  • Kudo, Hiroyuki; Sawada, Takanori; Kazawa, Elito
  • Biosensors and Bioelectronics, Vol. 22, Issue 4, p. 558-562
  • DOI: 10.1016/j.bios.2006.05.006