Response to Comment on "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism"

Journal Article · 28 October 2015 · Science

DOI: https://doi.org/10.1126/science.aab2595 · OSTI ID:1252754

Li, Fei ^[1]; Liu, Jian ^[1]; Zheng, Yi ^[1]; Garavito, R. Michael ^[1]; Ferguson-Miller, Shelagh ^[1]

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1. Univ. of California, San Diego, CA (United States)

Wang comments that the diffraction data for the structure of the A139T mutant of translocator protein TSPO from Rhodobacter sphaeroides should be used to 1.65 instead of 1.8 angstroms and that the density interpreted as porphyrin and monoolein is better fitted as polyethylene glycol. Although different practices of data processing exist, in this case they do not substantially influence the final map. Additional data are presented supporting the fit of a porphyrin and monooleins.

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• OSTI ID: 1252754
• Journal Information: Science, Journal Name: Science Journal Issue: 6260 Vol. 350; ISSN 0036-8075
• Publisher: AAASCopyright Statement
• Country of Publication: United States
• Language: ENGLISH