SerpinB1 Promotes Pancreatic β Cell Proliferation

El Ouaamari, Abdelfattah; Dirice, Ercument; Gedeon, Nicholas; Hu, Jiang; Zhou, Jian-Ying; Shirakawa, Jun; Hou, Lifei; Goodman, Jessica; Karampelias, Christos; Qiang, Guifeng; Boucher, Jeremie; Martinez, Rachael; Gritsenko, Marina A.; De Jesus, Dario F.; Kahraman, Sevim; Bhatt, Shweta; Smith, Richard D.; Beer, Hans-Dietmar; Jungtrakoon, Prapaporn; Gong, Yanping; Goldfine, Allison B.; Liew, Chong Wee; Doria, Alessandro; Andersson, Olov; Qian, Wei-Jun; Remold-O’Donnell, Eileen; Kulkarni, Rohit N.

doi:10.1016/j.cmet.2015.12.001

Title: SerpinB1 Promotes Pancreatic β Cell Proliferation

Full Record
Other Related Research

Publication Date:: Fri Jan 01 00:00:00 EST 2016

Sponsoring Org.:: USDOE

OSTI Identifier:: 1339000

Alternate Identifier(s):: OSTI ID: 1252573

Resource Type:: Published Article

Journal Name:: Cell Metabolism

Additional Journal Information:: Journal Name: Cell Metabolism Journal Volume: 23 Journal Issue: 1; Journal ID: ISSN 1550-4131

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Citation Formats


                    El Ouaamari, Abdelfattah, Dirice, Ercument, Gedeon, Nicholas, Hu, Jiang, Zhou, Jian-Ying, Shirakawa, Jun, Hou, Lifei, Goodman, Jessica, Karampelias, Christos, Qiang, Guifeng, Boucher, Jeremie, Martinez, Rachael, Gritsenko, Marina A., De Jesus, Dario F., Kahraman, Sevim, Bhatt, Shweta, Smith, Richard D., Beer, Hans-Dietmar, Jungtrakoon, Prapaporn, Gong, Yanping, Goldfine, Allison B., Liew, Chong Wee, Doria, Alessandro, Andersson, Olov, Qian, Wei-Jun, Remold-O’Donnell, Eileen, and Kulkarni, Rohit N. SerpinB1 Promotes Pancreatic β Cell Proliferation.  United States: N. p., 2016. 
Web.  doi:10.1016/j.cmet.2015.12.001.

Copy to clipboard


                    El Ouaamari, Abdelfattah, Dirice, Ercument, Gedeon, Nicholas, Hu, Jiang, Zhou, Jian-Ying, Shirakawa, Jun, Hou, Lifei, Goodman, Jessica, Karampelias, Christos, Qiang, Guifeng, Boucher, Jeremie, Martinez, Rachael, Gritsenko, Marina A., De Jesus, Dario F., Kahraman, Sevim, Bhatt, Shweta, Smith, Richard D., Beer, Hans-Dietmar, Jungtrakoon, Prapaporn, Gong, Yanping, Goldfine, Allison B., Liew, Chong Wee, Doria, Alessandro, Andersson, Olov, Qian, Wei-Jun, Remold-O’Donnell, Eileen, & Kulkarni, Rohit N. SerpinB1 Promotes Pancreatic β Cell Proliferation.  United States.  https://doi.org/10.1016/j.cmet.2015.12.001

Copy to clipboard


                    El Ouaamari, Abdelfattah, Dirice, Ercument, Gedeon, Nicholas, Hu, Jiang, Zhou, Jian-Ying, Shirakawa, Jun, Hou, Lifei, Goodman, Jessica, Karampelias, Christos, Qiang, Guifeng, Boucher, Jeremie, Martinez, Rachael, Gritsenko, Marina A., De Jesus, Dario F., Kahraman, Sevim, Bhatt, Shweta, Smith, Richard D., Beer, Hans-Dietmar, Jungtrakoon, Prapaporn, Gong, Yanping, Goldfine, Allison B., Liew, Chong Wee, Doria, Alessandro, Andersson, Olov, Qian, Wei-Jun, Remold-O’Donnell, Eileen, and Kulkarni, Rohit N. Fri .  
"SerpinB1 Promotes Pancreatic β Cell Proliferation".  United States.  https://doi.org/10.1016/j.cmet.2015.12.001.

Copy to clipboard


                    
@article{osti_1339000,

  title        = {SerpinB1 Promotes Pancreatic β Cell Proliferation},

  author       = {El Ouaamari, Abdelfattah and Dirice, Ercument and Gedeon, Nicholas and Hu, Jiang and Zhou, Jian-Ying and Shirakawa, Jun and Hou, Lifei and Goodman, Jessica and Karampelias, Christos and Qiang, Guifeng and Boucher, Jeremie and Martinez, Rachael and Gritsenko, Marina A. and De Jesus, Dario F. and Kahraman, Sevim and Bhatt, Shweta and Smith, Richard D. and Beer, Hans-Dietmar and Jungtrakoon, Prapaporn and Gong, Yanping and Goldfine, Allison B. and Liew, Chong Wee and Doria, Alessandro and Andersson, Olov and Qian, Wei-Jun and Remold-O’Donnell, Eileen and Kulkarni, Rohit N.},

  abstractNote = {},

  doi          = {10.1016/j.cmet.2015.12.001},

  journal      = {Cell Metabolism},

  number       = 1,

  volume       = 23,

  place        = {United States},

  year         = {Fri Jan 01 00:00:00 EST 2016},

  month        = {Fri Jan 01 00:00:00 EST 2016}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Publisher's Version of Record
https://doi.org/10.1016/j.cmet.2015.12.001

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 144 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

SerpinB1 Promotes Pancreatic β Cell Proliferation

Journal Article El Ouaamari, Abdelfattah ; Dirice, Ercument ; Gedeon, Nicholas ; ... - Cell Metabolism

Compensatory β-cell growth in response to insulin resistance is a common feature in diabetes. We recently reported that liver-derived factors participate in this compensatory response in the liver insulin receptor knockout (LIRKO) mouse, a model of significant islet hyperplasia. Here we show that serpinB1 is a liver-derived secretory protein that controls β-cell proliferation. SerpinB1 is abundant in the hepatocyte secretome and sera derived from LIRKO mice. SerpinB1 and small molecule compounds that partially mimic serpinB1 activity enhanced proliferation of zebrafish, mouse and human β-cells. We report that serpinB1-induced β-cell replication requires protease inhibition activity and mice lacking serpinB1 exhibit attenuatedmore »« less
https://doi.org/10.1016/j.cmet.2015.12.001
Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic β-cells

Journal Article Chen, Shan-Shan ; Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing ; Jiang, Teng ; ... - Biochemical and Biophysical Research Communications

Highlights: •PKR can be activated by glucolipitoxicity and pro-inflammatory cytokines in β-cells. •Activated PKR inhibited β-cell proliferation by arresting cell cycle at G1 phase. •Activated PKR fully abrogated the pro-proliferative effects of IGF-I on β-cells. -- Abstract: Double-stranded RNA-dependent protein kinase (PKR) is revealed to participate in the development of insulin resistance in peripheral tissues in type 2 diabetes (T2DM). Meanwhile, PKR is also characterized as a critical regulator of cell proliferation. To date, no study has focused on the impact of PKR on the proliferation of pancreatic β-cells. Here, we adopted insulinoma cell lines and mice islet β-cells tomore »« less
https://doi.org/10.1016/J.BBRC.2013.12.051
Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells

Journal Article Fangxu, Jiang ; Harrison, Leonard C - Experimental Cell Research

We previously reported that bone morphogenetic proteins (BMPs), members of the transforming growth factor superfamily, together with the basement membrane glycoprotein laminin-1 (Ln-1), promote proliferation of fetal pancreatic cells and formation of colonies containing peripheral insulin-positive cells. Here, we further investigate the cross-talk between BMP and Ln-1 signals. By RT-PCR, receptors for BMP (BMPR) (excepting BMPR-1B) and Ln-1 were expressed in the fetal pancreas between E13.5 and E17.5. Specific blocking antibodies to BMP-4 and -6 and selective BMP antagonists partially inhibited colony formation by fetal pancreas cells. Colony formation induced by BMP-6 and Ln-1 was completely abolished in a dose-dependentmore »« less
https://doi.org/10.1016/j.yexcr.2005.03.041
Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway

Journal Article Hama, Kouji ; Ohnishi, Hirohide ; Aoki, Hiroyoshi ; ... - Biochemical and Biophysical Research Communications

Activated pancreatic stellate cells (PSCs) play major roles in promoting pancreatic fibrosis. We previously reported that angiotensin II (Ang II) enhances activated PSC proliferation through EGF receptor transactivation. In the present study, we elucidated a novel intracellular mechanism by which Ang II stimulates cellular proliferation. TGF-{beta}{sub 1} inhibits activated PSC proliferation via a Smad3 and Smad4-dependent pathway in an autocrine manner. We demonstrated that Ang II inhibited TGF-{beta}{sub 1}-induced nuclear accumulation of Smad3 and Smad4. Furthermore, Ang II rapidly induced inhibitory Smad7 mRNA expression. Adenovirus-mediated Smad7 overexpression inhibited TGF-{beta}{sub 1}-induced nuclear accumulation of Smad3 and Smad4, and potentiated activated PSCmore »« less
https://doi.org/10.1016/j.bbrc.2005.12.069
IL-13 promotes the proliferation of rat pancreatic stellate cells through the suppression of NF-{kappa}B/TGF-{beta}{sub 1} pathway

Journal Article Shinozaki, Satoshi ; Mashima, Hirosato ; Ohnishi, Hirohide ; ... - Biochemical and Biophysical Research Communications

In chronic pancreatitis, pancreatic stellate cells (PSCs) play a central role in tissue fibrogenesis. Transforming growth factor {beta}{sub 1} (TGF-{beta}{sub 1}) and the Th2 lymphokines such as interleukin (IL)-13 are major profibrogenic cytokines in many organs. Activated PSCs produce various inflammatory cytokines including TGF-{beta}{sub 1}. In this study, we investigated whether IL-13 affects pancreatic fibrogenesis by modulating the functions of PSCs. IL-13 promoted PSCs proliferation without activation through the suppression of autocrine TGF-{beta}{sub 1}. IL-13 enhanced Stat6 phosphorylation in PSCs but Stat6 was not involved in the suppression of TGF-{beta}{sub 1}. IL-13 inhibited the transcriptional activity of NF-{kappa}B, and themore »« less
https://doi.org/10.1016/J.BBRC.2010.01.078

Similar Records