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Title: Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties

Here, silver nanoparticles have been of great interest as plasmonic substrates for sensing and imaging, catalysts, or antimicrobial systems. Their physical properties are strongly dependent on parameters that remain challenging to control such as size, chemical composition, and spatial distribution. We report here on supramolecular assemblies of a novel peptide amphiphile containing aldehyde functionality in order to reduce silver ions and subsequently nucleate silver metal nanoparticles in water. This system spontaneously generates monodisperse silver particles at fairly regular distances along the length of the filamentous organic assemblies. The metal–organic hybrid structures exhibited antimicrobial activity and significantly less toxicity toward eukaryotic cells. Metallized organic nanofibers of the type described here offer the possibility to create hydrogels, which integrate the useful functions of silver nanoparticles with controllable metallic content.
Authors:
 [1] ;  [2] ;  [2] ;  [3] ;  [3] ;  [3]
  1. Northwestern Univ., Chicago, IL (United States); Centre Tecnologic de la Quimica de Catalunya, Tarragona (Spain)
  2. Northwestern Univ., Chicago, IL (United States)
  3. Northwestern Univ., Chicago, IL (United States); Northwestern Univ., Evanston, IL (United States)
Publication Date:
Grant/Contract Number:
FG02-00ER45810
Type:
Published Article
Journal Name:
Journal of the American Chemical Society
Additional Journal Information:
Journal Volume: 138; Journal Issue: 17; Journal ID: ISSN 0002-7863
Publisher:
American Chemical Society (ACS)
Research Org:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
OSTI Identifier:
1250930
Alternate Identifier(s):
OSTI ID: 1439055

Pazos, Elena, Sleep, Eduard, Rubert Perez, Charles M., Lee, Sungsoo S., Tantakitti, Faifan, and Stupp, Samuel I.. Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties. United States: N. p., Web. doi:10.1021/jacs.6b01570.
Pazos, Elena, Sleep, Eduard, Rubert Perez, Charles M., Lee, Sungsoo S., Tantakitti, Faifan, & Stupp, Samuel I.. Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties. United States. doi:10.1021/jacs.6b01570.
Pazos, Elena, Sleep, Eduard, Rubert Perez, Charles M., Lee, Sungsoo S., Tantakitti, Faifan, and Stupp, Samuel I.. 2016. "Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties". United States. doi:10.1021/jacs.6b01570.
@article{osti_1250930,
title = {Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties},
author = {Pazos, Elena and Sleep, Eduard and Rubert Perez, Charles M. and Lee, Sungsoo S. and Tantakitti, Faifan and Stupp, Samuel I.},
abstractNote = {Here, silver nanoparticles have been of great interest as plasmonic substrates for sensing and imaging, catalysts, or antimicrobial systems. Their physical properties are strongly dependent on parameters that remain challenging to control such as size, chemical composition, and spatial distribution. We report here on supramolecular assemblies of a novel peptide amphiphile containing aldehyde functionality in order to reduce silver ions and subsequently nucleate silver metal nanoparticles in water. This system spontaneously generates monodisperse silver particles at fairly regular distances along the length of the filamentous organic assemblies. The metal–organic hybrid structures exhibited antimicrobial activity and significantly less toxicity toward eukaryotic cells. Metallized organic nanofibers of the type described here offer the possibility to create hydrogels, which integrate the useful functions of silver nanoparticles with controllable metallic content.},
doi = {10.1021/jacs.6b01570},
journal = {Journal of the American Chemical Society},
number = 17,
volume = 138,
place = {United States},
year = {2016},
month = {4}
}