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Title: Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties

Abstract

Here, silver nanoparticles have been of great interest as plasmonic substrates for sensing and imaging, catalysts, or antimicrobial systems. Their physical properties are strongly dependent on parameters that remain challenging to control such as size, chemical composition, and spatial distribution. We report here on supramolecular assemblies of a novel peptide amphiphile containing aldehyde functionality in order to reduce silver ions and subsequently nucleate silver metal nanoparticles in water. This system spontaneously generates monodisperse silver particles at fairly regular distances along the length of the filamentous organic assemblies. The metal–organic hybrid structures exhibited antimicrobial activity and significantly less toxicity toward eukaryotic cells. Metallized organic nanofibers of the type described here offer the possibility to create hydrogels, which integrate the useful functions of silver nanoparticles with controllable metallic content.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1]
  1. Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, Illinois 60611, United States
Publication Date:
Research Org.:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1250930
Alternate Identifier(s):
OSTI ID: 1439055
Grant/Contract Number:  
FG02-00ER45810
Resource Type:
Published Article
Journal Name:
Journal of the American Chemical Society
Additional Journal Information:
Journal Name: Journal of the American Chemical Society Journal Volume: 138 Journal Issue: 17; Journal ID: ISSN 0002-7863
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Pazos, Elena, Sleep, Eduard, Rubert Pérez, Charles M., Lee, Sungsoo S., Tantakitti, Faifan, and Stupp, Samuel I. Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties. United States: N. p., 2016. Web. doi:10.1021/jacs.6b01570.
Pazos, Elena, Sleep, Eduard, Rubert Pérez, Charles M., Lee, Sungsoo S., Tantakitti, Faifan, & Stupp, Samuel I. Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties. United States. doi:10.1021/jacs.6b01570.
Pazos, Elena, Sleep, Eduard, Rubert Pérez, Charles M., Lee, Sungsoo S., Tantakitti, Faifan, and Stupp, Samuel I. Fri . "Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties". United States. doi:10.1021/jacs.6b01570.
@article{osti_1250930,
title = {Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties},
author = {Pazos, Elena and Sleep, Eduard and Rubert Pérez, Charles M. and Lee, Sungsoo S. and Tantakitti, Faifan and Stupp, Samuel I.},
abstractNote = {Here, silver nanoparticles have been of great interest as plasmonic substrates for sensing and imaging, catalysts, or antimicrobial systems. Their physical properties are strongly dependent on parameters that remain challenging to control such as size, chemical composition, and spatial distribution. We report here on supramolecular assemblies of a novel peptide amphiphile containing aldehyde functionality in order to reduce silver ions and subsequently nucleate silver metal nanoparticles in water. This system spontaneously generates monodisperse silver particles at fairly regular distances along the length of the filamentous organic assemblies. The metal–organic hybrid structures exhibited antimicrobial activity and significantly less toxicity toward eukaryotic cells. Metallized organic nanofibers of the type described here offer the possibility to create hydrogels, which integrate the useful functions of silver nanoparticles with controllable metallic content.},
doi = {10.1021/jacs.6b01570},
journal = {Journal of the American Chemical Society},
number = 17,
volume = 138,
place = {United States},
year = {2016},
month = {4}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1021/jacs.6b01570

Citation Metrics:
Cited by: 23 works
Citation information provided by
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Works referencing / citing this record:

Preparation of an antimicrobial surface by direct assembly of antimicrobial peptide with its surface binding activity
journal, January 2017

  • Chen, Junjian; Zhu, Yuchen; Song, Yancheng
  • Journal of Materials Chemistry B, Vol. 5, Issue 13
  • DOI: 10.1039/c6tb03337g