Title: Orally bioavailable Syk inhibitors with activity in a rat PK/PD model

Journal Article · · Bioorganic and Medicinal Chemistry Letters

Not Available

Sponsoring Organization:
USDOE
Grant/Contract Number:
AC03-76SF00098
OSTI ID:
1250393
Journal Information:
Bioorganic and Medicinal Chemistry Letters, Journal Name: Bioorganic and Medicinal Chemistry Letters Journal Issue: 20 Vol. 25; ISSN 0960-894X
Publisher:
ElsevierCopyright Statement
Country of Publication:
United Kingdom
Language:
English

References (32)

A new synthesis of 2,1-benzisothiazoles journal October 1975
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis journal August 1991
Protein tyrosine kinase Syk in mast cell signaling journal September 2002
Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK) journal April 2003
Syk and pTyr'd: Signaling through the B cell antigen receptor journal July 2009
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor journal August 2011
Pyrazine-based Syk kinase inhibitors journal April 2012
Highly potent aminopyridines as Syk kinase inhibitors journal September 2012
Syk inhibitors with high potency in presence of blood journal May 2014
Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling journal May 2015
Discovery and Development of Spleen Tyrosine Kinase (SYK) Inhibitors journal February 2012
Rational Design of Highly Selective Spleen Tyrosine Kinase Inhibitors journal November 2012
Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors journal February 2013
Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors journal February 2014
Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase journal April 2014
Overcoming Mutagenicity and Ion Channel Activity: Optimization of Selective Spleen Tyrosine Kinase Inhibitors journal February 2015
A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design journal March 2015
Discovery and Profiling of a Selective and Efficacious Syk Inhibitor journal February 2015
Phenyl Carboxamide Analogues as Spleen Tyrosine Kinase (Syk) Inhibitors journal February 2014
Comprehensive analysis of kinase inhibitor selectivity journal October 2011
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond journal January 2006
The SYK tyrosine kinase: a crucial player in diverse biological functions journal May 2010
Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle journal March 2013
The tyrosine kinase network regulating mast cell activation journal March 2009
Autoinhibition and adapter function of Syk journal November 2009
R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation journal August 2006
Specific Inhibition of Spleen Tyrosine Kinase Suppresses Leukocyte Immune Function and Inflammation in Animal Models of Rheumatoid Arthritis journal October 2011
Inhibition of Spleen Tyrosine Kinase Attenuates Allergen-Mediated Airway Constriction journal December 2013
An analysis of the diaminopyrimidine patent estates describing spleen tyrosine kinase inhibitors by Rigel and Portola journal November 2010
Spleen tyrosine kinase inhibitors: a review of the patent literature 2010 – 2013 journal February 2014
Spleen tyrosine kinase: An Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases journal December 2009
Small-molecule inhibitors of spleen tyrosine kinase as therapeutic agents for immune disorders: will promise meet expectations? journal October 2014

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