Insights into the structure and function of membrane-integrated processive glycosyltransferases
Abstract
Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. In this paper, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG).
- Publication Date:
- Research Org.:
- Univ. of Virginia, Charlottesville, VA (United States); Energy Frontier Research Centers (EFRC) (United States). Center for Lignocellulose Structure and Formation (CLSF)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1344504
- Alternate Identifier(s):
- OSTI ID: 1250108
- Grant/Contract Number:
- SC0001090
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Current Opinion in Structural Biology
- Additional Journal Information:
- Journal Volume: 34; Journal ID: ISSN 0959-440X
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Bi, Yunchen, Hubbard, Caitlin, Purushotham, Pallinti, and Zimmer, Jochen. Insights into the structure and function of membrane-integrated processive glycosyltransferases. United States: N. p., 2015.
Web. doi:10.1016/j.sbi.2015.07.008.
Bi, Yunchen, Hubbard, Caitlin, Purushotham, Pallinti, & Zimmer, Jochen. Insights into the structure and function of membrane-integrated processive glycosyltransferases. United States. https://doi.org/10.1016/j.sbi.2015.07.008
Bi, Yunchen, Hubbard, Caitlin, Purushotham, Pallinti, and Zimmer, Jochen. Wed .
"Insights into the structure and function of membrane-integrated processive glycosyltransferases". United States. https://doi.org/10.1016/j.sbi.2015.07.008. https://www.osti.gov/servlets/purl/1344504.
@article{osti_1344504,
title = {Insights into the structure and function of membrane-integrated processive glycosyltransferases},
author = {Bi, Yunchen and Hubbard, Caitlin and Purushotham, Pallinti and Zimmer, Jochen},
abstractNote = {Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. In this paper, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG).},
doi = {10.1016/j.sbi.2015.07.008},
journal = {Current Opinion in Structural Biology},
number = ,
volume = 34,
place = {United States},
year = {Wed Sep 02 00:00:00 EDT 2015},
month = {Wed Sep 02 00:00:00 EDT 2015}
}
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