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Title: Completing the link between exposure science and toxicology for improved environmental health decision making: The aggregate exposure pathway framework

Abstract

Here, driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for exposure science analogous to the “systems approaches” used in the biological sciences is a necessary step in this evolution. Here we propose the aggregate exposure pathway (AEP) concept as the natural and complementary companion in the exposure sciences to the adverse outcome pathway (AOP) concept in the toxicological sciences. Aggregate exposure pathways offer an intuitive framework to organize exposure data within individual units of prediction common to the field, setting the stage for exposure forecasting. Looking farther ahead, we envision direct linkages between aggregate exposure pathways and adverse outcome pathways, completing the source to outcome continuum for more meaningful integration of exposure assessment and hazard identification. Together, the two frameworks form and inform a decision-making framework with the flexibility for risk-based, hazard-based, or exposure-based decision making.

Authors:
 [1];  [2];  [2];  [3];  [4];  [5];  [4];  [4];  [4];  [4];  [5];  [4];  [4];  [4]
+ Show Author Affiliations
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Oregon State Univ., Corvallis, OR (United States)
  2. U.S. Environmental Protection Agency, Durham, NC (United States)
  3. Oak Ridge Institute for Science and Education, Oak Ridge, TN (United States)
  4. Oregon State Univ., Corvallis, OR (United States)
  5. Oregon State Univ., Corvallis, OR (United States); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1249371
Report Number(s):
PNNL-SA-114098
Journal ID: ISSN 0013-936X
Grant/Contract Number:  
P30 ES000210; AC05-7601830
Resource Type:
Accepted Manuscript
Journal Name:
Environmental Science and Technology
Additional Journal Information:
Journal Volume: 136; Journal Issue: 2; Journal ID: ISSN 0013-936X
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 54 ENVIRONMENTAL SCIENCES

Citation Formats

Teeguarden, Justin G., Tan, Yu -Mei, Edwards, Stephen W., Leonard, Jeremy A., Anderson, Kim A., Corley, Richard A., Kile, Molly L., Simonich, Staci M., Stone, David, Tanguay, Robert L., Waters, Katrina M., Harper, Stacey L., Williams, David E., and Harding, Anna K. Completing the link between exposure science and toxicology for improved environmental health decision making: The aggregate exposure pathway framework. United States: N. p., 2016. Web. doi:10.1021/acs.est.5b05311.
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Teeguarden, Justin G., Tan, Yu -Mei, Edwards, Stephen W., Leonard, Jeremy A., Anderson, Kim A., Corley, Richard A., Kile, Molly L., Simonich, Staci M., Stone, David, Tanguay, Robert L., Waters, Katrina M., Harper, Stacey L., Williams, David E., & Harding, Anna K. Completing the link between exposure science and toxicology for improved environmental health decision making: The aggregate exposure pathway framework. United States. https://doi.org/10.1021/acs.est.5b05311
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Teeguarden, Justin G., Tan, Yu -Mei, Edwards, Stephen W., Leonard, Jeremy A., Anderson, Kim A., Corley, Richard A., Kile, Molly L., Simonich, Staci M., Stone, David, Tanguay, Robert L., Waters, Katrina M., Harper, Stacey L., Williams, David E., and Harding, Anna K. Wed . "Completing the link between exposure science and toxicology for improved environmental health decision making: The aggregate exposure pathway framework". United States. https://doi.org/10.1021/acs.est.5b05311. https://www.osti.gov/servlets/purl/1249371.
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@article{osti_1249371,
title = {Completing the link between exposure science and toxicology for improved environmental health decision making: The aggregate exposure pathway framework},
author = {Teeguarden, Justin G. and Tan, Yu -Mei and Edwards, Stephen W. and Leonard, Jeremy A. and Anderson, Kim A. and Corley, Richard A. and Kile, Molly L. and Simonich, Staci M. and Stone, David and Tanguay, Robert L. and Waters, Katrina M. and Harper, Stacey L. and Williams, David E. and Harding, Anna K.},
abstractNote = {Here, driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for exposure science analogous to the “systems approaches” used in the biological sciences is a necessary step in this evolution. Here we propose the aggregate exposure pathway (AEP) concept as the natural and complementary companion in the exposure sciences to the adverse outcome pathway (AOP) concept in the toxicological sciences. Aggregate exposure pathways offer an intuitive framework to organize exposure data within individual units of prediction common to the field, setting the stage for exposure forecasting. Looking farther ahead, we envision direct linkages between aggregate exposure pathways and adverse outcome pathways, completing the source to outcome continuum for more meaningful integration of exposure assessment and hazard identification. Together, the two frameworks form and inform a decision-making framework with the flexibility for risk-based, hazard-based, or exposure-based decision making.},
doi = {10.1021/acs.est.5b05311},
journal = {Environmental Science and Technology},
number = 2,
volume = 136,
place = {United States},
year = {Wed Jan 13 00:00:00 EST 2016},
month = {Wed Jan 13 00:00:00 EST 2016}
}
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https://doi.org/10.1021/acs.est.5b05311
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    Works referencing / citing this record:

    How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology
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    The future trajectory of adverse outcome pathways: a commentary
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    • Tan, Yu-Mei; Leonard, Jeremy A.; Edwards, Stephen
    • Environmental Science: Processes & Impacts, Vol. 20, Issue 3
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    Beyond monoisotopic accurate mass spectrometry: ancillary techniques for identifying unknown features in non-targeted discovery analysis
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    Regulatory assessment and risk management of chemical mixtures: challenges and ways forward
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    Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS)
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    Regulatory assessment and risk management of chemical mixtures: challenges and ways forward
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    Regulatory assessment and risk management of chemical mixtures: challenges and ways forward
    text, January 2019

    Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment
    journal, August 2019

    • Perkins, Edward J.; Ashauer, Roman; Burgoon, Lyle
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    Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
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    Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
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