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Title: Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma

Here, primary effusion lymphoma (PEL) is a rare large B-cell neoplasm particularly affecting immunodeficient hosts with an increased incidence in young or middle-aged males infected with the HIV. 1 The clinical outcome of patients with PEL is unfavorable with a median survival of <6 months. 1 PEL has been closely associated with human herpes virus 8 (HHV8, previously called Kaposi sarcoma herpesvirus) infection. 1 In some cases a coinfection of HHV8 with the Epstein–Barr Virus (EBV) has been described. 1 HHV8 encodes various genes homologous to cellular genes that have proliferative and anti-apoptotic functions. 2 Although HHV8 is supposed to be a major driver of PEL, it alone is not sufficient for a full-blown lymphomagenesis. 2 PEL usually shows complex karyotypes with many chromosomal aberrations. 3 This chromosomal complexity might be driven by the viral infection and lead to genetic alterations cooperating with HHV8 in PEL lymphomagenesis. 4
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [1] ;  [5] ;  [1] ;  [6] ;  [6] ;  [1]
  1. Univ. Hospital Schleswig-Holstein, Christian-Albrechts-Univ., Kiel (Germany)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. Univ. Hospital of Cologne, Cologne (Germany)
  4. Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Heidelberg (Germany)
  5. Leibniz-Institute DSMZ, Braunschweig (Germany)
  6. Wellcome Trust Cancer Sanger Institute, Hinxton (United Kingdom)
Publication Date:
Report Number(s):
LA-UR-15-20054
Journal ID: ISSN 0887-6924; leu201522
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Leukemia
Additional Journal Information:
Journal Volume: 29; Journal Issue: 7; Journal ID: ISSN 0887-6924
Publisher:
Nature Publishing Group (NPG)
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES
OSTI Identifier:
1248630