Effects of non-invasive brain stimulation on associative memory
Abstract
Associative memory refers to remembering the association between two items, such as a face and a name. It is a crucial part of daily life, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer’s disease. Evidence suggests that transcranial direct current stimulation (tDCS) can improve memory performance, but few tDCS studies have investigated its impact on associative memory. In addition, no prior study of the effects of tDCS on memory performance has systematically evaluated the impact of tDCS on different types of memory assessments, such as recognition and recall tests. In this study, we measured the effects of tDCS on associative memory performance in healthy adults, using both recognition and recall tests. Participants studied face-name pairs while receiving either active (30 minutes, 2 mA) or sham (30 minutes, 0.1 mA) stimulation with the anode placed at F9 and the cathode placed on the contralateral upper arm. Participants in the active stimulation group performed significantly better on the recall test than participants in the sham group, recalling 50% more names, on average, and making fewer recall errors. However, the two groups did not differ significantly in terms of their performancemore »
- Authors:
-
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)'
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)'; Univ. of New Mexico, Albuquerque, NM (United States)
- Univ. of Illinois, Chicago, IL (United States)
- Publication Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1339280
- Alternate Identifier(s):
- OSTI ID: 1246660
- Report Number(s):
- SAND-2017-0115J
Journal ID: ISSN 0006-8993; PII: S000689931500579X
- Grant/Contract Number:
- AC04-94AL85000
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Brain Research
- Additional Journal Information:
- Journal Volume: 1624; Journal ID: ISSN 0006-8993
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; tDCS; Associative Memory; Recall; Recognition
Citation Formats
Matzen, Laura E., Trumbo, Michael C., Leach, Ryan C., and Leshikar, Eric D. Effects of non-invasive brain stimulation on associative memory. United States: N. p., 2015.
Web. doi:10.1016/j.brainres.2015.07.036.
Matzen, Laura E., Trumbo, Michael C., Leach, Ryan C., & Leshikar, Eric D. Effects of non-invasive brain stimulation on associative memory. United States. https://doi.org/10.1016/j.brainres.2015.07.036
Matzen, Laura E., Trumbo, Michael C., Leach, Ryan C., and Leshikar, Eric D. Thu .
"Effects of non-invasive brain stimulation on associative memory". United States. https://doi.org/10.1016/j.brainres.2015.07.036. https://www.osti.gov/servlets/purl/1339280.
@article{osti_1339280,
title = {Effects of non-invasive brain stimulation on associative memory},
author = {Matzen, Laura E. and Trumbo, Michael C. and Leach, Ryan C. and Leshikar, Eric D.},
abstractNote = {Associative memory refers to remembering the association between two items, such as a face and a name. It is a crucial part of daily life, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer’s disease. Evidence suggests that transcranial direct current stimulation (tDCS) can improve memory performance, but few tDCS studies have investigated its impact on associative memory. In addition, no prior study of the effects of tDCS on memory performance has systematically evaluated the impact of tDCS on different types of memory assessments, such as recognition and recall tests. In this study, we measured the effects of tDCS on associative memory performance in healthy adults, using both recognition and recall tests. Participants studied face-name pairs while receiving either active (30 minutes, 2 mA) or sham (30 minutes, 0.1 mA) stimulation with the anode placed at F9 and the cathode placed on the contralateral upper arm. Participants in the active stimulation group performed significantly better on the recall test than participants in the sham group, recalling 50% more names, on average, and making fewer recall errors. However, the two groups did not differ significantly in terms of their performance on the recognition memory test. This investigation provides evidence that stimulation at the time of study improves associative memory encoding, but that this memory benefit is evident only under certain retrieval conditions.},
doi = {10.1016/j.brainres.2015.07.036},
journal = {Brain Research},
number = ,
volume = 1624,
place = {United States},
year = {Thu Jul 30 00:00:00 EDT 2015},
month = {Thu Jul 30 00:00:00 EDT 2015}
}
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Works referenced in this record:
Recognition and Source Memory as Multivariate Decision Processes
journal, July 2000
- Banks, William P.
- Psychological Science, Vol. 11, Issue 4
Mechanisms of Action Underlying the Effect of Repetitive Transcranial Magnetic Stimulation on Mood: Behavioral and Brain Imaging Studies
journal, March 2004
- Barrett, Jennifer; Della-Maggiore, Valeria; Chouinard, Philippe A.
- Neuropsychopharmacology, Vol. 29, Issue 6
Signal detection with criterion noise: Applications to recognition memory.
journal, January 2009
- Benjamin, Aaron S.; Diaz, Michael; Wee, Serena
- Psychological Review, Vol. 116, Issue 1
Prolonged visual memory enhancement after direct current stimulation in Alzheimer's disease
journal, July 2012
- Boggio, Paulo Sergio; Ferrucci, Roberta; Mameli, Francesca
- Brain Stimulation, Vol. 5, Issue 3
Temporal Lobe Cortical Electrical Stimulation during the Encoding and Retrieval Phase Reduces False Memories
journal, March 2009
- Boggio, Paulo S.; Fregni, Felipe; Valasek, Claudia
- PLoS ONE, Vol. 4, Issue 3
Visual memory improved by non-invasive brain stimulation
journal, September 2010
- Chi, Richard P.; Fregni, Felipe; Snyder, Allan W.
- Brain Research, Vol. 1353
TDCS guided using fMRI significantly accelerates learning to identify concealed objects
journal, January 2012
- Clark, Vincent P.; Coffman, Brian A.; Mayer, Andy R.
- NeuroImage, Vol. 59, Issue 1
Enhancement of object detection with transcranial direct current stimulation is associated with increased attention
journal, January 2012
- Coffman, Brian A.; Trumbo, Michael C.; Clark, Vincent P.
- BMC Neuroscience, Vol. 13, Issue 1
Battery powered thought: Enhancement of attention, learning, and memory in healthy adults using transcranial direct current stimulation
journal, January 2014
- Coffman, Brian A.; Clark, Vincent P.; Parasuraman, Raja
- NeuroImage, Vol. 85
Noninvasive brain stimulation: from physiology to network dynamics and back
journal, June 2013
- Dayan, Eran; Censor, Nitzan; Buch, Ethan R.
- Nature Neuroscience, Vol. 16, Issue 7
Perception of comfort during transcranial DC stimulation: Effect of NaCl solution concentration applied to sponge electrodes
journal, May 2007
- Dundas, J. E.; Thickbroom, G. W.; Mastaglia, F. L.
- Clinical Neurophysiology, Vol. 118, Issue 5
FACES—A database of facial expressions in young, middle-aged, and older women and men: Development and validation
journal, February 2010
- Ebner, Natalie C.; Riediger, Michaela; Lindenberger, Ulman
- Behavior Research Methods, Vol. 42, Issue 1
Direct current induced short-term modulation of the left dorsolateral prefrontal cortex while learning auditory presented nouns
journal, January 2009
- Elmer, Stefan; Burkard, Marcel; Renz, Basil
- Behavioral and Brain Functions, Vol. 5, Issue 1
Transcranial Direct Current Stimulation Augments Perceptual Sensitivity and 24-Hour Retention in a Complex Threat Detection Task
journal, April 2012
- Falcone, Brian; Coffman, Brian A.; Clark, Vincent P.
- PLoS ONE, Vol. 7, Issue 4
Transcranial Direct Current Stimulation Improves Word Retrieval in Healthy and Nonfluent Aphasic Subjects
journal, September 2011
- Fiori, Valentina; Coccia, Michela; Marinelli, Chiara V.
- Journal of Cognitive Neuroscience, Vol. 23, Issue 9
Noninvasive Brain Stimulation Improves Language Learning
journal, August 2008
- Flöel, Agnes; Rösser, Nina; Michka, Olesya
- Journal of Cognitive Neuroscience, Vol. 20, Issue 8
Non-invasive brain stimulation improves object-location learning in the elderly
journal, August 2012
- Flöel, Agnes; Suttorp, Wiebke; Kohl, Oliver
- Neurobiology of Aging, Vol. 33, Issue 8
Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory
journal, July 2005
- Fregni, Felipe; Boggio, Paulo S.; Nitsche, Michael
- Experimental Brain Research, Vol. 166, Issue 1
Paired associate performance in the early detection of DAT
journal, January 2002
- Fowler, Kylie S.; Saling, Michael M.; Conway, Elizabeth L.
- Journal of the International Neuropsychological Society, Vol. 8, Issue 1
It's the Thought That Counts: Examining the Task-dependent Effects of Transcranial Direct Current Stimulation on Executive Function
journal, March 2015
- Gill, Jay; Shah-Basak, Priyanka P.; Hamilton, Roy
- Brain Stimulation, Vol. 8, Issue 2
Own-Ethnicity Bias in the Recognition of Black, East Asian, Hispanic, and White Faces
journal, May 2009
- Gross, Thomas F.
- Basic and Applied Social Psychology, Vol. 31, Issue 2
Overlap between the Neural Correlates of Cued Recall and Source Memory: Evidence for a Generic Recollection Network?
journal, May 2012
- Hayama, Hiroki R.; Vilberg, Kaia L.; Rugg, Michael D.
- Journal of Cognitive Neuroscience, Vol. 24, Issue 5
Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity
journal, January 2015
- Hunter, Michael A.; Coffman, Brian A.; Gasparovic, Charles
- Brain Research, Vol. 1594
Oppositional transcranial direct current stimulation (tDCS) of parietal substrates of attention during encoding modulates episodic memory
journal, February 2012
- Jacobson, Liron; Goren, Nir; Lavidor, Michal
- Brain Research, Vol. 1439
Transcranial Direct Current Stimulation (tDCS) Enhances Reconsolidation of Long-Term Memory
journal, July 2013
- Javadi, Amir Homayoun; Cheng, Paul
- Brain Stimulation, Vol. 6, Issue 4
Short duration transcranial direct current stimulation (tDCS) modulates verbal memory
journal, October 2012
- Javadi, Amir Homayoun; Cheng, Paul; Walsh, Vincent
- Brain Stimulation, Vol. 5, Issue 4
Transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex modulates declarative memory
journal, July 2012
- Javadi, Amir Homayoun; Walsh, Vincent
- Brain Stimulation, Vol. 5, Issue 3
Differences in the experience of active and sham transcranial direct current stimulation
journal, April 2012
- Kessler, Sudha Kilaru; Turkeltaub, Peter E.; Benson, Jennifer G.
- Brain Stimulation, Vol. 5, Issue 2
Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs
journal, January 2013
- Lakens, Daniël
- Frontiers in Psychology, Vol. 4
Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability
journal, October 2002
- Liebetanz, D.
- Brain, Vol. 125, Issue 10
Memory skills elders want to improve
journal, September 1990
- Leirer, Von O.; Morrow, Daniel G.; Sheikh, Javaid I.
- Experimental Aging Research, Vol. 16, Issue 3
Enhancing verbal episodic memory in older and young subjects after non-invasive brain stimulation
journal, January 2013
- Manenti, Rosa; Brambilla, Michela; Petesi, Michela
- Frontiers in Aging Neuroscience, Vol. 5
Transcranial brain stimulation studies of episodic memory in young adults, elderly adults and individuals with memory dysfunction: A review
journal, April 2012
- Manenti, Rosa; Cotelli, Maria; Robertson, Ian H.
- Brain Stimulation, Vol. 5, Issue 2
Transcranial Direct Current Stimulation during Sleep Improves Declarative Memory
journal, November 2004
- Marshall, L.
- Journal of Neuroscience, Vol. 24, Issue 44
Remembering words not presented in sentences: How study context changes patterns of false memories
journal, January 2009
- Matzen, Laura E.; Benjamin, Aaron S.
- Memory & Cognition, Vol. 37, Issue 1
What does the ratio of injected current to electrode area tell us about current density in the brain during tDCS?
journal, June 2009
- Miranda, Pedro Cavaleiro; Faria, Paula; Hallett, Mark
- Clinical Neurophysiology, Vol. 120, Issue 6
Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation
journal, September 2000
- Nitsche, M. A.; Paulus, W.
- The Journal of Physiology, Vol. 527, Issue 3
Comparison of the neural correlates of retrieval success in tests of cued recall and recognition memory
journal, March 2011
- Okada, Kayoko; Vilberg, Kaia L.; Rugg, Michael D.
- Human Brain Mapping, Vol. 33, Issue 3
Time-dependent effect of transcranial direct current stimulation on the enhancement of working memory
journal, January 2008
- Ohn, Suk Hoon; Park, Chang-Il; Yoo, Woo-Kyoung
- NeuroReport, Vol. 19, Issue 1
The assessment and analysis of handedness: The Edinburgh inventory
journal, March 1971
- Oldfield, R. C.
- Neuropsychologia, Vol. 9, Issue 1
Hypermnesia Occurs in Recall but Not in Recognition
journal, July 1987
- Payne, David G.; Iii, Henry L. Roediger
- The American Journal of Psychology, Vol. 100, Issue 2
Effects of Transcranial Direct Current Stimulation on Episodic Memory Related to Emotional Visual Stimuli
journal, May 2010
- Penolazzi, Barbara; Di Domenico, Alberto; Marzoli, Daniele
- PLoS ONE, Vol. 5, Issue 5
Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients
journal, May 2007
- Poreisz, Csaba; Boros, Klára; Antal, Andrea
- Brain Research Bulletin, Vol. 72, Issue 4-6
The own-age bias in face recognition: A meta-analytic and theoretical review.
journal, January 2012
- Rhodes, Matthew G.; Anastasi, Jeffrey S.
- Psychological Bulletin, Vol. 138, Issue 1
Strengthening of horizontal cortical connections following skill learning
journal, July 1998
- Rioult-Pedotti, Mengia -S.; Friedman, Daniel; Hess, Grzegorz
- Nature Neuroscience, Vol. 1, Issue 3
Noninvasive stimulation of prefrontal cortex strengthens existing episodic memories and reduces forgetting in the elderly
journal, October 2014
- Sandrini, Marco; Brambilla, Michela; Manenti, Rosa
- Frontiers in Aging Neuroscience, Vol. 6
Enhancing language performance with non-invasive brain stimulation—A transcranial direct current stimulation study in healthy humans
journal, January 2008
- Sparing, Roland; Dafotakis, Manuel; Meister, Ingo G.
- Neuropsychologia, Vol. 46, Issue 1
fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease
journal, January 2003
- Sperling, R. A.
- Journal of Neurology, Neurosurgery & Psychiatry, Vol. 74, Issue 1
Putting names to faces:
journal, October 2003
- Sperling, Reisa; Chua, Elizabeth; Cocchiarella, Andrew
- NeuroImage, Vol. 20, Issue 2
Memory retrieval and the parietal cortex: A review of evidence from a dual-process perspective
journal, June 2008
- Vilberg, Kaia L.; Rugg, Michael D.
- Neuropsychologia, Vol. 46, Issue 7
An own gender bias and the importance of hair in face recognition
journal, September 2003
- Wright, Daniel B.; Sladden, Benjamin
- Acta Psychologica, Vol. 114, Issue 1
The Nature of Recollection and Familiarity: A Review of 30 Years of Research
journal, April 2002
- Yonelinas, Andrew P.
- Journal of Memory and Language, Vol. 46, Issue 3
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journal, March 2020
- Bartl, Gergely Janos; Blackshaw, Emily; Crossman, Margot
- Zeitschrift für Psychologie, Vol. 228, Issue 1
Differential Age Effects of Transcranial Direct Current Stimulation on Associative Memory
journal, February 2018
- Leach, Ryan C.; McCurdy, Matthew P.; Trumbo, Michael C.
- The Journals of Gerontology: Series B, Vol. 74, Issue 7
Transcranial Direct Current Stimulation over the Prefrontal Cortex Alters Encoding and Judgments of Learning Based on Fluency
journal, November 2019
- Gaynor, Alexandra M.; Chua, Elizabeth F.
- Journal of Cognitive Neuroscience, Vol. 31, Issue 11
tDCS over the prefrontal cortex alters objective but not subjective encoding
journal, August 2016
- Gaynor, Alexandra M.; Chua, Elizabeth F.
- Cognitive Neuroscience, Vol. 8, Issue 3
Viability of tDCS in Military Environments for Performance Enhancement: A Systematic Review
journal, November 2019
- Feltman, Kathryn A.; Hayes, Amanda M.; Bernhardt, Kyle A.
- Military Medicine, Vol. 185, Issue 1-2
Transcranial stimulation over the left inferior frontal gyrus increases false alarms in an associative memory task in older adults
journal, January 2016
- Leach, Ryan C.; McCurdy, Matthew P.; Trumbo, Michael C.
- Healthy Aging Research, Vol. 5
Transcranial stimulation over the left inferior frontal gyrus increases false alarms in an associative memory task in older adults
journal, January 2016
- Leach, Ryan C.; McCurdy, Matthew P.; Trumbo, Michael C.
- Healthy Aging Research, Vol. 05, Issue 01
Transcranial stimulation over the left inferior frontal gyrus increases false alarms in an associative memory task in older adults
journal, January 2016
- Leach, Ryan C.; McCurdy, Matthew P.; Trumbo, Michael C.
- Healthy Aging Research, Vol. 5, Issue 8
Theta band high definition transcranial alternating current stimulation, but not transcranial direct current stimulation, improves associative memory performance
journal, June 2019
- Lang, Stefan; Gan, Liu Shi; Alrazi, Tazrina
- Scientific Reports, Vol. 9, Issue 1