Triazine‐Based Sequence‐Defined Polymers with Side‐Chain Diversity and Backbone–Backbone Interaction Motifs
Abstract
Abstract Sequence control in polymers, well‐known in nature, encodes structure and functionality. Here we introduce a new architecture, based on the nucleophilic aromatic substitution chemistry of cyanuric chloride, that creates a new class of sequence‐defined polymers dubbed TZPs. Proof of concept is demonstrated with two synthesized hexamers, having neutral and ionizable side chains. Molecular dynamics simulations show backbone–backbone interactions, including H‐bonding motifs and pi–pi interactions. This architecture is arguably biomimetic while differing from sequence‐defined polymers having peptide bonds. The synthetic methodology supports the structural diversity of side chains known in peptides, as well as backbone–backbone hydrogen‐bonding motifs, and will thus enable new macromolecules and materials with useful functions.
- Authors:
-
- Pacific Northwest National Laboratory P.O. Box 999 Richland WA 99352 USA
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1241918
- Alternate Identifier(s):
- OSTI ID: 1241919
- Resource Type:
- Published Article
- Journal Name:
- Angewandte Chemie
- Additional Journal Information:
- Journal Name: Angewandte Chemie Journal Volume: 128 Journal Issue: 12; Journal ID: ISSN 0044-8249
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Germany
- Language:
- English
Citation Formats
Grate, Jay W., Mo, Kai‐For, and Daily, Michael D. Triazine‐Based Sequence‐Defined Polymers with Side‐Chain Diversity and Backbone–Backbone Interaction Motifs. Germany: N. p., 2016.
Web. doi:10.1002/ange.201509864.
Grate, Jay W., Mo, Kai‐For, & Daily, Michael D. Triazine‐Based Sequence‐Defined Polymers with Side‐Chain Diversity and Backbone–Backbone Interaction Motifs. Germany. https://doi.org/10.1002/ange.201509864
Grate, Jay W., Mo, Kai‐For, and Daily, Michael D. Wed .
"Triazine‐Based Sequence‐Defined Polymers with Side‐Chain Diversity and Backbone–Backbone Interaction Motifs". Germany. https://doi.org/10.1002/ange.201509864.
@article{osti_1241918,
title = {Triazine‐Based Sequence‐Defined Polymers with Side‐Chain Diversity and Backbone–Backbone Interaction Motifs},
author = {Grate, Jay W. and Mo, Kai‐For and Daily, Michael D.},
abstractNote = {Abstract Sequence control in polymers, well‐known in nature, encodes structure and functionality. Here we introduce a new architecture, based on the nucleophilic aromatic substitution chemistry of cyanuric chloride, that creates a new class of sequence‐defined polymers dubbed TZPs. Proof of concept is demonstrated with two synthesized hexamers, having neutral and ionizable side chains. Molecular dynamics simulations show backbone–backbone interactions, including H‐bonding motifs and pi–pi interactions. This architecture is arguably biomimetic while differing from sequence‐defined polymers having peptide bonds. The synthetic methodology supports the structural diversity of side chains known in peptides, as well as backbone–backbone hydrogen‐bonding motifs, and will thus enable new macromolecules and materials with useful functions.},
doi = {10.1002/ange.201509864},
journal = {Angewandte Chemie},
number = 12,
volume = 128,
place = {Germany},
year = {Wed Feb 10 00:00:00 EST 2016},
month = {Wed Feb 10 00:00:00 EST 2016}
}
https://doi.org/10.1002/ange.201509864
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