Title: Preparation of highly luminescent and color tunable carbon nanodots under visible light excitation for in vitro and in vivo bio-imaging

Journal Article · · Journal of Materials Research
 [1];  [2];  [2];  [3];  [3];  [2];  [4];  [5];  [2]
  1. Beijing Univ. of Technology, Beijing (China)
  2. Chinese Academy of Sciences, Jilin, (People's Republic of China)
  3. Chinese Academy of Sciences, Jilin (People's Republic of China)
  4. Beijing Univ. of Technology, Beijing (People's Republic of China); Chinese Academy of Sciences, Jilin, (People's Republic of China)
  5. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Univ. of New Mexico, Albuquerque, NM (United States)
+ Show Author Affiliations

Carbon nanodots (CDs) have generated enormous excitement because of their superiority in water solubility, chemical inertness, low toxicity, ease of functionalization and resistance to photobleaching. Here we report a facile thermal pyrolysis route to prepare CDs with high quantum yield (QY) using citric acid as the carbon source and ethylene diamine derivatives (EDAs) including triethylenetetramine (TETA), tetraethylenepentamine (TEPA) and polyene polyamine (PEPA) as the passivation agents. We find that the CDs prepared from EDAs, such as TETA, TEPA and PEPA, show relatively high photoluminescence (PL) QY (11.4, 10.6, and 9.8%, respectively) at 1ex of 465 nm. The cytotoxicity of the CDs has been investigated through in vitro and in vivo bio-imaging studies. The results indicate that these CDs possess low toxicity and good biocompatibility. As a result, the unique properties such as the high PL QY at large excitation wave length and the low toxicity of the resulting CDs make them promising fluorescent nanoprobes for applications in optical bio-imaging and biosensing.

Research Organization:
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Grant/Contract Number:
AC04-94AL85000
OSTI ID:
1240098
Report Number(s):
SAND2016-0800J; 618955
Journal Information:
Journal of Materials Research, Journal Name: Journal of Materials Research Journal Issue: 22 Vol. 30; ISSN 0884-2914
Publisher:
Materials Research SocietyCopyright Statement
Country of Publication:
United States
Language:
English

References (35)

Highly Luminescent Organosilane-Functionalized Carbon Dots journal February 2011
Hydrothermal Treatment of Grass: A Low-Cost, Green Route to Nitrogen-Doped, Carbon-Rich, Photoluminescent Polymer Nanodots as an Effective Fluorescent Sensing Platform for Label-Free Detection of Cu(II) Ions journal March 2012
Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy journal June 2012
Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine journal March 2014
Three Colors Emission from S,N Co-doped Graphene Quantum Dots for Visible Light H 2 Production and Bioimaging journal January 2015
Fluorescent Carbon Nanoparticles Derived from Candle Soot journal August 2007
Water-Soluble Fluorescent Carbon Quantum Dots and Photocatalyst Design journal June 2010
Luminescent Carbon Nanodots: Emergent Nanolights journal August 2010
Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions journal March 2012
Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging journal February 2013
Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence journal May 2012
On–Off–On Fluorescent Carbon Dot Nanosensor for Recognition of Chromium(VI) and Ascorbic Acid Based on the Inner Filter Effect journal December 2013
Photoluminescent Carbogenic Dots journal July 2008
Nanosized Carbon Particles From Natural Gas Soot journal July 2009
Electrophoretic Analysis and Purification of Fluorescent Single-Walled Carbon Nanotube Fragments journal October 2004
Quantum-Sized Carbon Dots for Bright and Colorful Photoluminescence journal June 2006
An Electrochemical Avenue to Blue Luminescent Nanocrystals from Multiwalled Carbon Nanotubes (MWCNTs) journal January 2007
Carbon Dots for Multiphoton Bioimaging journal September 2007
Carbon Nanoparticles as Visible-Light Photocatalysts for Efficient CO 2 Conversion and Beyond journal April 2011
Formation Mechanism of Carbogenic Nanoparticles with Dual Photoluminescence Emission journal December 2011
Carbon Dots for Optical Imaging in Vivo journal August 2009
Deep Ultraviolet Photoluminescence of Water-Soluble Self-Passivated Graphene Quantum Dots journal May 2012
Color-Switchable Electroluminescence of Carbon Dot Light-Emitting Diodes journal November 2013
Tailoring color emissions from N-doped graphene quantum dots for bioimaging applications journal December 2015
Microwave synthesis of fluorescent carbon nanoparticles with electrochemiluminescence properties journal January 2009
Intrinsically fluorescent carbon dots with tunable emission derived from hydrothermal treatment of glucose in the presence of monopotassium phosphate journal January 2011
Facile access to versatile fluorescent carbon dots toward light-emitting diodes journal January 2012
Facile synthesis of graphitic carbon quantum dots with size tunability and uniformity using reverse micelles journal January 2012
Highly luminescent carbon nanodots by microwave-assisted pyrolysis journal January 2012
Large scale electrochemical synthesis of high quality carbon nanodots and their photocatalytic property journal January 2012
One-step ultrasonic synthesis of fluorescent N-doped carbon dots from glucose and their visible-light sensitive photocatalytic ability journal January 2012
Highly luminescent S, N co-doped graphene quantum dots with broad visible absorption bands for visible light photocatalysts journal January 2013
Carbon “quantum” dots for optical bioimaging journal January 2013
Metal-free efficient photocatalyst for stable visible water splitting via a two-electron pathway journal February 2015
Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging journal January 2012

Cited By (3)

Graphene quantum dot-based theranostic agents for active targeting of breast cancer journal January 2017
Facile and scalable preparation of highly luminescent N,S co-doped graphene quantum dots and their application for parallel detection of multiple metal ions journal January 2017
Short-wave infrared emitted/excited fluorescence from carbon dots and preliminary applications in bioimaging journal January 2018

Similar Records

Hydrothermal syntheses, crystal structures and characterization of new vanadoborates: The novel decorated cage cluster [V₆B₂₂O₄₄(OH)₁₀]
Journal Article · 2013 · Journal of Solid State Chemistry · OSTI ID:22306270
+3 more
Modified polyamines for CO{sub 2} absorption. Product preparation and characterization
Journal Article · 2000 · Industrial and Engineering Chemistry Research · OSTI ID:20076078
+2 more
Dynamics of Magnetic Skyrmions in Nanodots
Journal Article · 2018 · Physics of the Solid State · OSTI ID:22770961

Related Subjects

36 MATERIALS SCIENCE