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Title: Revealing the mechanism of passive transport in lipid bilayers via phonon-mediated nanometre-scale density fluctuations

Abstract

We report the high resolution inelastic x-ray study of the in-plane phonon excitations in dipalmitoyl phosphatidylcholine (DPPC) above and below main transition temperature. In the Lβ' gel phase, we observe high frequency longitudinal phonon mode previously predicted by the molecular dynamics simulations and for the first time, we reveal low frequency weakly dispersive transverse acoustic mode which softens and exhibits a low-frequency phonon gap when the DPPC lipid transitions into the Lα fluid phase. The phonon softening of the high frequency longitudinal excitations and the transformation of the transverse excitations upon the phase transition from the Lβ' to Lα phase is explained within the framework of the phonon theory of liquids. These findings illustrate the importance of the collective dynamics of biomembranes and reveal that hydrocarbon tails can act as an efficient mediator in controlling the passive transport across the bilayer plane.

Authors:
 [1];  [1];  [2];  [3];  [4];  [1];  [5];  [1]
  1. Brookhaven National Lab. (BNL), Upton, NY (United States)
  2. Joint Inst. for Nuclear Research (JINR), Dubna (Russian Federation)
  3. Inst. of Nanoscience and Cryogenics, Grenoble (France)
  4. Petersburg Nuclear Physics Inst. Gatchina (Russia)
  5. European Synchrotron Radiation Facility (ESRF), Grenoble (France)
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); Russian Foundation for Basic Research
OSTI Identifier:
1237168
Alternate Identifier(s):
OSTI ID: 1340385
Report Number(s):
BNL-108276-2015-JA; BNL-112571-2016-JA
Journal ID: ISSN 2041-1723; R&D Project: LS001
Grant/Contract Number:  
SC0012704
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 7; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; Membrane biophysics; Membrane lipids; 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Zhernenkov, Mikhail, Bolmatov, Dima, Soloviov, Dmitry, Zhernenkov, Kirill, Toperverg, Boris P., Cunsolo, Alessandro, Bosak, Alexey, and Cai, Yong. Revealing the mechanism of passive transport in lipid bilayers via phonon-mediated nanometre-scale density fluctuations. United States: N. p., 2016. Web. doi:10.1038/ncomms11575.
Zhernenkov, Mikhail, Bolmatov, Dima, Soloviov, Dmitry, Zhernenkov, Kirill, Toperverg, Boris P., Cunsolo, Alessandro, Bosak, Alexey, & Cai, Yong. Revealing the mechanism of passive transport in lipid bilayers via phonon-mediated nanometre-scale density fluctuations. United States. doi:10.1038/ncomms11575.
Zhernenkov, Mikhail, Bolmatov, Dima, Soloviov, Dmitry, Zhernenkov, Kirill, Toperverg, Boris P., Cunsolo, Alessandro, Bosak, Alexey, and Cai, Yong. Thu . "Revealing the mechanism of passive transport in lipid bilayers via phonon-mediated nanometre-scale density fluctuations". United States. doi:10.1038/ncomms11575. https://www.osti.gov/servlets/purl/1237168.
@article{osti_1237168,
title = {Revealing the mechanism of passive transport in lipid bilayers via phonon-mediated nanometre-scale density fluctuations},
author = {Zhernenkov, Mikhail and Bolmatov, Dima and Soloviov, Dmitry and Zhernenkov, Kirill and Toperverg, Boris P. and Cunsolo, Alessandro and Bosak, Alexey and Cai, Yong},
abstractNote = {We report the high resolution inelastic x-ray study of the in-plane phonon excitations in dipalmitoyl phosphatidylcholine (DPPC) above and below main transition temperature. In the Lβ' gel phase, we observe high frequency longitudinal phonon mode previously predicted by the molecular dynamics simulations and for the first time, we reveal low frequency weakly dispersive transverse acoustic mode which softens and exhibits a low-frequency phonon gap when the DPPC lipid transitions into the Lα fluid phase. The phonon softening of the high frequency longitudinal excitations and the transformation of the transverse excitations upon the phase transition from the Lβ' to Lα phase is explained within the framework of the phonon theory of liquids. These findings illustrate the importance of the collective dynamics of biomembranes and reveal that hydrocarbon tails can act as an efficient mediator in controlling the passive transport across the bilayer plane.},
doi = {10.1038/ncomms11575},
journal = {Nature Communications},
number = ,
volume = 7,
place = {United States},
year = {2016},
month = {5}
}

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Cited by: 11 works
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