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Title: A Potent d -Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo

Authors:
 [1] ;  [2] ;  [2] ;  [3] ;  [4] ;  [5] ;  [5] ;  [1] ;  [6] ;  [2] ;  [1]
  1. Banting and Best Department of Medical Research and Department of Molecular Genetics, the Donnelly Centre, University of Toronto, Toronto, Ontario, Canada M5S 3E1
  2. Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, United States
  3. Pharmacokinetics &, Drug Metabolism, Amgen, Inc., Thousand Oaks, California 91320, United States
  4. Therapeutic Discovery, Amgen, Inc., Thousand Oaks, California 91320, United States
  5. Antibody Solutions, Sunnyvale, California 94089, United States
  6. Reflexion Pharmaceuticals, Inc., San Francisco, California 94104, United States
Publication Date:
Grant/Contract Number:
AC02-06CH11357
Type:
Published Article
Journal Name:
ACS Chemical Biology
Additional Journal Information:
Journal Volume: 11; Journal Issue: 4; Related Information: CHORUS Timestamp: 2017-12-06 10:32:19; Journal ID: ISSN 1554-8929
Publisher:
American Chemical Society
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
OSTI Identifier:
1236725