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Title: Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy

Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence-expressed in terms of total cross sections-as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Thus the consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies.
Authors:
 [1] ;  [1] ;  [2] ;  [2] ;  [3] ;  [2] ;  [2] ;  [2]
  1. Univ. de Bordeaux, CNRS/IN2P3, Gradignan (France)
  2. CONICET and Univ. Nacional de Rosario, Rosario (Argentina)
  3. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Report Number(s):
SAND-2015-1838J
Journal ID: ISSN 0031-9155; 579662
Grant/Contract Number:
AC04-94AL85000
Type:
Accepted Manuscript
Journal Name:
Physics in Medicine and Biology
Additional Journal Information:
Journal Volume: 60; Journal Issue: 20; Journal ID: ISSN 0031-9155
Publisher:
IOP Publishing
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA)
Country of Publication:
United States
Language:
English
Subject:
73 NUCLEAR PHYSICS AND RADIATION PHYSICS
OSTI Identifier:
1236225

Champion, Christophe, Quinto, Michele A., Monti, Juan M., Galassi, Mariel E., Weck, Philippe F., Fojon, Omar A., Hanssen, Jocelyn, and Rivarola, Roberto D.. Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy. United States: N. p., Web. doi:10.1088/0031-9155/60/20/7805.
Champion, Christophe, Quinto, Michele A., Monti, Juan M., Galassi, Mariel E., Weck, Philippe F., Fojon, Omar A., Hanssen, Jocelyn, & Rivarola, Roberto D.. Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy. United States. doi:10.1088/0031-9155/60/20/7805.
Champion, Christophe, Quinto, Michele A., Monti, Juan M., Galassi, Mariel E., Weck, Philippe F., Fojon, Omar A., Hanssen, Jocelyn, and Rivarola, Roberto D.. 2015. "Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy". United States. doi:10.1088/0031-9155/60/20/7805. https://www.osti.gov/servlets/purl/1236225.
@article{osti_1236225,
title = {Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy},
author = {Champion, Christophe and Quinto, Michele A. and Monti, Juan M. and Galassi, Mariel E. and Weck, Philippe F. and Fojon, Omar A. and Hanssen, Jocelyn and Rivarola, Roberto D.},
abstractNote = {Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence-expressed in terms of total cross sections-as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Thus the consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies.},
doi = {10.1088/0031-9155/60/20/7805},
journal = {Physics in Medicine and Biology},
number = 20,
volume = 60,
place = {United States},
year = {2015},
month = {9}
}