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Title: Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy

Abstract

Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence-expressed in terms of total cross sections-as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Thus the consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies.

Authors:
 [1];  [1];  [2];  [2];  [3];  [2];  [2];  [2]
  1. Univ. de Bordeaux, CNRS/IN2P3, Gradignan (France)
  2. CONICET and Univ. Nacional de Rosario, Rosario (Argentina)
  3. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1236225
Report Number(s):
SAND-2015-1838J
Journal ID: ISSN 0031-9155; 579662
Grant/Contract Number:  
AC04-94AL85000
Resource Type:
Accepted Manuscript
Journal Name:
Physics in Medicine and Biology
Additional Journal Information:
Journal Volume: 60; Journal Issue: 20; Journal ID: ISSN 0031-9155
Publisher:
IOP Publishing
Country of Publication:
United States
Language:
English
Subject:
73 NUCLEAR PHYSICS AND RADIATION PHYSICS

Citation Formats

Champion, Christophe, Quinto, Michele A., Monti, Juan M., Galassi, Mariel E., Weck, Philippe F., Fojon, Omar A., Hanssen, Jocelyn, and Rivarola, Roberto D. Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy. United States: N. p., 2015. Web. doi:10.1088/0031-9155/60/20/7805.
Champion, Christophe, Quinto, Michele A., Monti, Juan M., Galassi, Mariel E., Weck, Philippe F., Fojon, Omar A., Hanssen, Jocelyn, & Rivarola, Roberto D. Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy. United States. doi:10.1088/0031-9155/60/20/7805.
Champion, Christophe, Quinto, Michele A., Monti, Juan M., Galassi, Mariel E., Weck, Philippe F., Fojon, Omar A., Hanssen, Jocelyn, and Rivarola, Roberto D. Fri . "Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy". United States. doi:10.1088/0031-9155/60/20/7805. https://www.osti.gov/servlets/purl/1236225.
@article{osti_1236225,
title = {Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy},
author = {Champion, Christophe and Quinto, Michele A. and Monti, Juan M. and Galassi, Mariel E. and Weck, Philippe F. and Fojon, Omar A. and Hanssen, Jocelyn and Rivarola, Roberto D.},
abstractNote = {Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence-expressed in terms of total cross sections-as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Thus the consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies.},
doi = {10.1088/0031-9155/60/20/7805},
journal = {Physics in Medicine and Biology},
number = 20,
volume = 60,
place = {United States},
year = {2015},
month = {9}
}

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Cited by: 12 works
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