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Title: A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources

Abstract

The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. Lastly, the setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply.

Authors:
 [1];  [1];  [1];  [1];  [1];  [2];  [3];  [3];  [4];  [1]
  1. Diamond Light Source, Oxfordshire (United Kingdom)
  2. SLAC National Accelerator Lab., Menlo Park, CA (United States)
  3. Univ. of Toronto, Toronto, ON (Canada)
  4. Univ. of Toronto, Toronto, ON (Canada); The Max Planck Institute for the Structure and Dynamics of Matter, and Hamburg Centre for Ultrafast Imaging, Hamburg (Germany)
Publication Date:
Research Org.:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1234721
Grant/Contract Number:  
AC02-76SF00515
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Synchrotron Radiation (Online)
Additional Journal Information:
Journal Name: Journal of Synchrotron Radiation (Online); Journal Volume: 22; Journal Issue: 6; Journal ID: ISSN 1600-5775
Publisher:
International Union of Crystallography
Country of Publication:
United States
Language:
English
Subject:
07 ISOTOPE AND RADIATION SOURCES; fixed-target serial femtosecond crystallography; portable endstation; motion control; sample delivery

Citation Formats

Sherrell, Darren A., Foster, Andrew J., Hudson, Lee, Nutter, Brian, O'Hea, James, Nelson, Silke, Pare-Labrosse, Olivier, Oghbaey, Saeed, Miller, R. J. Dwayne, and Owen, Robin L. A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources. United States: N. p., 2015. Web. doi:10.1107/S1600577515016938.
Sherrell, Darren A., Foster, Andrew J., Hudson, Lee, Nutter, Brian, O'Hea, James, Nelson, Silke, Pare-Labrosse, Olivier, Oghbaey, Saeed, Miller, R. J. Dwayne, & Owen, Robin L. A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources. United States. doi:10.1107/S1600577515016938.
Sherrell, Darren A., Foster, Andrew J., Hudson, Lee, Nutter, Brian, O'Hea, James, Nelson, Silke, Pare-Labrosse, Olivier, Oghbaey, Saeed, Miller, R. J. Dwayne, and Owen, Robin L. Thu . "A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources". United States. doi:10.1107/S1600577515016938. https://www.osti.gov/servlets/purl/1234721.
@article{osti_1234721,
title = {A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources},
author = {Sherrell, Darren A. and Foster, Andrew J. and Hudson, Lee and Nutter, Brian and O'Hea, James and Nelson, Silke and Pare-Labrosse, Olivier and Oghbaey, Saeed and Miller, R. J. Dwayne and Owen, Robin L.},
abstractNote = {The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. Lastly, the setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply.},
doi = {10.1107/S1600577515016938},
journal = {Journal of Synchrotron Radiation (Online)},
number = 6,
volume = 22,
place = {United States},
year = {2015},
month = {1}
}

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Cited by: 11 works
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