Kinetic and Mechanistic Examination of Acid–Base Bifunctional Aminosilica Catalysts in Aldol and Nitroaldol Condensations
Abstract
The kinetic and mechanistic understanding of cooperatively catalyzed aldol and nitroaldol condensations is probed using a series of mesoporous silicas functionalized with aminosilanes to provide bifunctional acid-base character. Mechanistically, a Hammett analysis is performed to determine the effects of electron-donating and electron-withdrawing groups of para-substituted benzaldehyde derivatives on the catalytic activity of each condensation reaction. This information is also used to discuss the validity of previously proposed catalytic mechanisms and to propose a revised mechanism with plausible reaction intermediates. For both reactions, electron-withdrawing groups increase the observed rates of reaction, though resonance effects played an important, yet subtle, role in the nitroaldol condensation, in which a p-methoxy electron-donating group was also able to stabilize the proposed carbocation intermediate. Additionally, activation energies and pre-exponential factors are calculated via the Arrhenius analysis of two catalysts with similar amine loadings: one catalyst had silanols available for cooperative interactions (acid-base catalysis) while the other was treated with a silanol-capping reagent to prevent such cooperativity (base only catalysis). The values obtained for activation energies and pre-exponential factors in each reaction are discussed in the context of the proposed mechanisms and the importance of cooperative interactions in each reaction. The catalytic activity decreases for all reactionsmore »
- Authors:
-
- School of Chemical &, Biomolecular Engineering Georgia Institute of Technology 311 Ferst Drive NW, Atlanta, Georgia 30332, United States
- Publication Date:
- Research Org.:
- Georgia Institute of Technology, Atlanta, GA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division
- OSTI Identifier:
- 1234153
- Alternate Identifier(s):
- OSTI ID: 1439317; OSTI ID: 1657457
- Grant/Contract Number:
- FG02-03ER15459
- Resource Type:
- Published Article
- Journal Name:
- ACS Catalysis
- Additional Journal Information:
- Journal Name: ACS Catalysis Journal Volume: 6 Journal Issue: 1; Journal ID: ISSN 2155-5435
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Arrhenius analysis; bifunctional acid-base catalysts; carbon-carbon coupling; condensation reactions; cooperative catalysis; Hammett analysis
Citation Formats
Collier, Virginia E., Ellebracht, Nathan C., Lindy, George I., Moschetta, Eric G., and Jones, Christopher W. Kinetic and Mechanistic Examination of Acid–Base Bifunctional Aminosilica Catalysts in Aldol and Nitroaldol Condensations. United States: N. p., 2015.
Web. doi:10.1021/acscatal.5b02398.
Collier, Virginia E., Ellebracht, Nathan C., Lindy, George I., Moschetta, Eric G., & Jones, Christopher W. Kinetic and Mechanistic Examination of Acid–Base Bifunctional Aminosilica Catalysts in Aldol and Nitroaldol Condensations. United States. https://doi.org/10.1021/acscatal.5b02398
Collier, Virginia E., Ellebracht, Nathan C., Lindy, George I., Moschetta, Eric G., and Jones, Christopher W. Fri .
"Kinetic and Mechanistic Examination of Acid–Base Bifunctional Aminosilica Catalysts in Aldol and Nitroaldol Condensations". United States. https://doi.org/10.1021/acscatal.5b02398.
@article{osti_1234153,
title = {Kinetic and Mechanistic Examination of Acid–Base Bifunctional Aminosilica Catalysts in Aldol and Nitroaldol Condensations},
author = {Collier, Virginia E. and Ellebracht, Nathan C. and Lindy, George I. and Moschetta, Eric G. and Jones, Christopher W.},
abstractNote = {The kinetic and mechanistic understanding of cooperatively catalyzed aldol and nitroaldol condensations is probed using a series of mesoporous silicas functionalized with aminosilanes to provide bifunctional acid-base character. Mechanistically, a Hammett analysis is performed to determine the effects of electron-donating and electron-withdrawing groups of para-substituted benzaldehyde derivatives on the catalytic activity of each condensation reaction. This information is also used to discuss the validity of previously proposed catalytic mechanisms and to propose a revised mechanism with plausible reaction intermediates. For both reactions, electron-withdrawing groups increase the observed rates of reaction, though resonance effects played an important, yet subtle, role in the nitroaldol condensation, in which a p-methoxy electron-donating group was also able to stabilize the proposed carbocation intermediate. Additionally, activation energies and pre-exponential factors are calculated via the Arrhenius analysis of two catalysts with similar amine loadings: one catalyst had silanols available for cooperative interactions (acid-base catalysis) while the other was treated with a silanol-capping reagent to prevent such cooperativity (base only catalysis). The values obtained for activation energies and pre-exponential factors in each reaction are discussed in the context of the proposed mechanisms and the importance of cooperative interactions in each reaction. The catalytic activity decreases for all reactions when the silanols are capped with trimethylsilyl groups and higher temperatures are required to make accurate rate measurements, emphasizing the vital role the weakly acidic silanols play in the catalytic cycles. The results indicate that loss of acid sites is more detrimental to the catalytic activity of the aldol condensation than the nitroaldol condensation, as evidenced by the significant decrease in the pre-exponential factor for the aldol condensation when silanols are unavailable for cooperative interactions. Cooperative catalysis is evidenced by significant changes in the pre-exponential factor, rather than the activation energy for the aldol condensation.},
doi = {10.1021/acscatal.5b02398},
journal = {ACS Catalysis},
number = 1,
volume = 6,
place = {United States},
year = {Fri Dec 04 00:00:00 EST 2015},
month = {Fri Dec 04 00:00:00 EST 2015}
}
https://doi.org/10.1021/acscatal.5b02398
Web of Science
Works referenced in this record:
Acid−Base Bifunctional and Dielectric Outer-Sphere Effects in Heterogeneous Catalysis: A Comparative Investigation of Model Primary Amine Catalysts
journal, March 2006
- Bass, John D.; Solovyov, Andrew; Pascall, Andrew J.
- Journal of the American Chemical Society, Vol. 128, Issue 11
Optimizing Acid−Base Bifunctional Mesoporous Catalysts for the Henry Reaction: Effects of the Surface Density and Site Isolation of Functional Groups
journal, December 2008
- Sharma, Krishna K.; Buckley, Robert P.; Asefa, Tewodros
- Langmuir, Vol. 24, Issue 24
Catalytic Upgrading of Biomass-Derived Methyl Ketones to Liquid Transportation Fuel Precursors by an Organocatalytic Approach
journal, February 2015
- Sankaranarayanapillai, Shylesh; Sreekumar, Sanil; Gomes, Joseph
- Angewandte Chemie International Edition, Vol. 54, Issue 15
Electrostatic Basis for Enzyme Catalysis
journal, August 2006
- Warshel, Arieh; Sharma, Pankaz K.; Kato, Mitsunori
- Chemical Reviews, Vol. 106, Issue 8
Comparison of Nitroaldol Reaction Mechanisms Using Accurate Ab Initio Calculations
journal, October 2008
- Zorn, Deborah; Lin, Victor S. -Y.; Pruski, Marek
- The Journal of Physical Chemistry A, Vol. 112, Issue 42
A survey of Hammett substituent constants and resonance and field parameters
journal, March 1991
- Hansch, Corwin.; Leo, A.; Taft, R. W.
- Chemical Reviews, Vol. 91, Issue 2
Bifunctional Acid-Base Cooperativity in Heterogeneous Catalytic Reactions: Advances in Silica Supported Organic Functional Groups
journal, December 2010
- Shylesh, Sankaranarayanapillai; Thiel, Werner R.
- ChemCatChem, Vol. 3, Issue 2
Acid–base cooperativity in condensation reactions with functionalized mesoporous silica catalysts
journal, April 2009
- Hruby, Sarah L.; Shanks, Brent H.
- Journal of Catalysis, Vol. 263, Issue 1
Reaction-dependent heteroatom modification of acid–base catalytic cooperativity in aminosilica materials
journal, September 2015
- Moschetta, Eric G.; Brunelli, Nicholas A.; Jones, Christopher W.
- Applied Catalysis A: General, Vol. 504
Asymmetric Carbon-Carbon Bond Formation under Continuous-Flow Conditions with Chiral Heterogeneous Catalysts
journal, May 2013
- Tsubogo, Tetsu; Ishiwata, Takanori; Kobayashi, Shū
- Angewandte Chemie International Edition, Vol. 52, Issue 26
Experimental and Theoretical Study of n -Butanal Self-Condensation over Ti Species Supported on Silica
journal, July 2014
- Hanna, David G.; Shylesh, Sankaranarayanapillai; Li, Yi-Pei
- ACS Catalysis, Vol. 4, Issue 9
Tailoring the Cooperative Acid-Base Effects in Silica-Supported Amine Catalysts: Applications in the Continuous Gas-Phase Self-Condensation of n -Butanal
journal, March 2014
- Shylesh, Sankaranarayanapillai; Hanna, David; Gomes, Joseph
- ChemCatChem
Ru-, Rh-, and Pd-Catalyzed C−C Bond Formation Involving C−H Activation and Addition on Unsaturated Substrates: Reactions and Mechanistic Aspects
journal, May 2002
- Ritleng, Vincent; Sirlin, Claude; Pfeffer, Michel
- Chemical Reviews, Vol. 102, Issue 5
Expanding the toolbox of asymmetric organocatalysis by continuous-flow process
journal, January 2015
- Finelli, Fernanda G.; Miranda, Leandro S. M.; de Souza, Rodrigo O. M. A.
- Chemical Communications, Vol. 51, Issue 18
Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way
journal, February 1995
- Trost, Barry M.
- Angewandte Chemie International Edition in English, Vol. 34, Issue 3
Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation
journal, February 2010
- Colby, Denise A.; Bergman, Robert G.; Ellman, Jonathan A.
- Chemical Reviews, Vol. 110, Issue 2
Tuning Cooperativity by Controlling the Linker Length of Silica-Supported Amines in Catalysis and CO 2 Capture
journal, August 2012
- Brunelli, Nicholas A.; Didas, Stephanie A.; Venkatasubbaiah, Krishnan
- Journal of the American Chemical Society, Vol. 134, Issue 34
Supported organic catalysts: synthesis of ( E )-nitrostyrenes from nitroalkanes and aromatic aldehydes over propylamine supported on MCM-41 silica as a reusable catalyst
journal, March 2001
- Demicheli, Giuseppina; Maggi, Raimondo; Mazzacani, Alessandro
- Tetrahedron Letters, Vol. 42, Issue 12
The effect of acid–base pairing on catalysis: An efficient acid–base functionalized catalyst for aldol condensation
journal, April 2007
- Zeidan, R.; Davis, M.
- Journal of Catalysis, Vol. 247, Issue 2
Characterization of Highly Ordered MCM-41 Silicas Using X-ray Diffraction and Nitrogen Adsorption
journal, August 1999
- Kruk, Michal; Jaroniec, Mietek; Kim, Ji Man
- Langmuir, Vol. 15, Issue 16
Separation/recycling methods for homogeneous transition metal catalysts in continuous flow
journal, January 2015
- Vural Gürsel, Iris; Noël, Timothy; Wang, Qi
- Green Chemistry, Vol. 17, Issue 4
Substituent- and Catalyst-Dependent Selectivity to Aldol or Nitrostyrene Products in a Heterogeneous Base-Catalyzed Henry Reaction
journal, January 2010
- Sharma, Krishnaâ K.; Biradar, Ankushâ V.; Asefa, Tewodros
- ChemCatChem, Vol. 2, Issue 1
Electrophilic Substituent Constants
journal, September 1958
- Brown, Herbert C.; Okamoto, Y.
- Journal of the American Chemical Society, Vol. 80, Issue 18
Cooperative Catalysis with Acid–Base Bifunctional Mesoporous Silica: Impact of Grafting and Co-condensation Synthesis Methods on Material Structure and Catalytic Properties
journal, June 2012
- Brunelli, Nicholas A.; Venkatasubbaiah, Krishnan; Jones, Christopher W.
- Chemistry of Materials, Vol. 24, Issue 13
Catalysis using multifunctional organosiliceous hybrid materials
journal, January 2013
- Díaz, Urbano; Brunel, Daniel; Corma, Avelino
- Chemical Society Reviews, Vol. 42, Issue 9
Silanol-Assisted Aldol Condensation on Aminated Silica: Understanding the Arrangement of Functional Groups
journal, October 2013
- Lauwaert, Jeroen; De Canck, Els; Esquivel, Dolores
- ChemCatChem, Vol. 6, Issue 1
Substrate inhibition in the heterogeneous catalyzed aldol condensation: A mechanistic study of supported organocatalysts
journal, July 2012
- Kandel, Kapil; Althaus, Stacey M.; Peeraphatdit, Chorthip
- Journal of Catalysis, Vol. 291
Cooperative Catalysis of Primary and Tertiary Amines Immobilized on Oxide Surfaces for One-Pot CC Bond Forming Reactions
journal, September 2008
- Motokura, Ken; Tada, Mizuki; Iwasawa, Yasuhiro
- Angewandte Chemie International Edition, Vol. 47, Issue 48
Designing bifunctional acid–base mesoporous hybrid catalysts for cascade reactions
journal, January 2013
- Gianotti, Enrica; Diaz, Urbano; Velty, Alexandra
- Catalysis Science & Technology, Vol. 3, Issue 10
Bifunctional Mesoporous Materials with Coexisting Acidic and Basic Sites for CC Bond Formation in Co-operative Catalytic Reactions
journal, July 2010
- Shylesh, Sankaranarayanapillai; Wagener, Alex; Seifert, Andreas
- ChemCatChem, Vol. 2, Issue 10
Engineering the third wave of biocatalysis
journal, May 2012
- Bornscheuer, U. T.; Huisman, G. W.; Kazlauskas, R. J.
- Nature, Vol. 485, Issue 7397
Multifunctional Heterogeneous Catalysts: SBA-15-Containing Primary Amines and Sulfonic Acids
journal, September 2006
- Zeidan, Ryan K.; Hwang, Son-Jong; Davis, Mark E.
- Angewandte Chemie International Edition, Vol. 45, Issue 38
Effects of amine structure and base strength on acid–base cooperative aldol condensation
journal, May 2015
- Lauwaert, Jeroen; De Canck, Els; Esquivel, Dolores
- Catalysis Today, Vol. 246
Substituent Constants for Aromatic Substitution 1-3
journal, April 1957
- Brown, Herbert C.; Okamoto, Y.
- Journal of the American Chemical Society, Vol. 79, Issue 8
Syntheses of Biodiesel Precursors: Sulfonic Acid Catalysts for Condensation of Biomass-Derived Platform Molecules
journal, March 2014
- Balakrishnan, Madhesan; Sacia, Eric R.; Bell, Alexis T.
- ChemSusChem, Vol. 7, Issue 4
Evaluating Pore Sizes in Mesoporous Materials: A Simplified Standard Adsorption Method and a Simplified Broekhoff−de Boer Method
journal, August 1999
- Lukens,, Wayne W.; Schmidt-Winkel, Patrick; Zhao, Dongyuan
- Langmuir, Vol. 15, Issue 16
The Role of Hydroxyl Group Acidity on the Activity of Silica-Supported Secondary Amines for the Self-Condensation of n -Butanal
journal, October 2014
- Shylesh, Sankaranarayanapillai; Hanna, David; Gomes, Joseph
- ChemSusChem, Vol. 8, Issue 3
Spatial arrangement and acid strength effects on acid–base cooperatively catalyzed aldol condensation on aminosilica materials
journal, May 2015
- Lauwaert, Jeroen; Moschetta, Eric G.; Van Der Voort, Pascal
- Journal of Catalysis, Vol. 325
Cooperative catalysis by silica-supported organic functional groups
journal, January 2008
- Margelefsky, Eric L.; Zeidan, Ryan K.; Davis, Mark E.
- Chemical Society Reviews, Vol. 37, Issue 6
Tuning acid–base cooperativity to create next generation silica-supported organocatalysts
journal, December 2013
- Brunelli, Nicholas A.; Jones, Christopher W.
- Journal of Catalysis, Vol. 308
Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism
journal, October 1992
- Kresge, C. T.; Leonowicz, M. E.; Roth, W. J.
- Nature, Vol. 359, Issue 6397, p. 710-712