skip to main content

DOE PAGESDOE PAGES

Title: Genomic Perspectives of Transcriptional Regulation in Forebrain Development

The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric disorders are due to genetic defects affecting forebrain development, making it imperative to understand the underlying genetic circuitry. We report that recent progress now makes it possible to begin fully elucidating the genomic regulatory mechanisms that control forebrain gene expression. Here, we discuss the current knowledge of how transcription factors drive gene expression programs through their interactions with cis-acting genomic elements, such as enhancers; how analyses of chromatin and DNA modifications provide insights into gene expression states; and how these approaches yield insights into the evolution of the human brain.
Authors:
 [1] ;  [2] ;  [3] ;  [2]
  1. Univ. of California, Davis, CA (United States)
  2. Univ. of California, San Francisco, CA (United States)
  3. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); DOE Joint Genome Inst., Walnut Creek, CA (United States); Univ. of California, Merced, CA (United States)
Publication Date:
Grant/Contract Number:
AC02-05CH11231; GM105202; R01NS062859A; R01HG003988; R01NS34661; R01MH081880; R37MH049428; T32 GMO7618
Type:
Published Article
Journal Name:
Neuron
Additional Journal Information:
Journal Volume: 85; Journal Issue: 1; Journal ID: ISSN 0896-6273
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES
OSTI Identifier:
1234146
Alternate Identifier(s):
OSTI ID: 1257835