Tools for the microbiome. Nano and beyond
Here, the microbiome presents great opportunities for understanding and improving the world around us and elucidating the interactions that compose it. The microbiome also poses tremendous challenges for mapping and manipulating the entangled networks of interactions among myriad diverse organisms. Here, we describe the opportunities, technical needs, and potential approaches to address these challenges, based on recent and upcoming advances in measurement and control at the nanoscale and beyond. Moreover, these technical needs will provide the basis for advancing the largely descriptive studies of the microbiome to the theoretical and mechanistic understandings that will underpin the discipline of microbiome engineering. We anticipate that the new tools and methods developed will also be more broadly useful in environmental monitoring, medicine, forensics, and other areas.
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- Univ. of Michigan, Ann Arbor, MI (United States)
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- Marine Biological Lab., Woods Hole, MA (United States)
- The Kavli Foundation, Oxnard, CA (United States)
- Harvard Medical School, Boston, MA (United States); Harvard Univ., Boston, MA (United States)
- Univ. of California, San Diego, La Jolla, CA (United States)
- Univ. of Southern California, Los Angeles, CA (United States)
- Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, Chicago, IL (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Univ. of California, Los Angeles, CA (United States)
- Stanford Univ., Stanford, CA (United States)
- Univ. of Hawaii-Manoa, Honolulu, HI (United States)
- Harvard Univ., Boston, MA (United States); Harvard Medical School, Boston, MA (United States)
- Center for Marine Cytometry, Concrete, WA (United States); Univ. de Concepcion, Concepcion (Chile)
- Publication Date:
- Report Number(s):
- PNNL-SA-115178
Journal ID: ISSN 1936-0851; KP1601010
- Grant/Contract Number:
- AC05-76RL01830; OBER; PNNL - DE-AC06-76RL01830
- Type:
- Published Article
- Journal Name:
- ACS Nano
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 1936-0851
- Publisher:
- American Chemical Society
- Research Org:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org:
- USDOE
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
- OSTI Identifier:
- 1233975
- Alternate Identifier(s):
- OSTI ID: 1237801
Biteen, Julie S., Blainey, Paul C., Cardon, Zoe G., Chun, Miyoung, Church, George, Dorrestein, Pieter C., Fraser, Scott E., Gilbert, Jack A., Jansson, Janet K., Knight, Rob, Miller, Jeff F., Ozcan, Aydogan, Prather, Kimberly A., Quake, Stephen R., Ruby, Edward G., Silver, Pamela A., Taha, Sharif A., van den Engh, Ger, Weiss, Paul S., Wong, Gerard C. L., Wright, Aaron T., and Young, Thomas D.. Tools for the microbiome. Nano and beyond. United States: N. p.,
Web. doi:10.1021/acsnano.5b07826.
Biteen, Julie S., Blainey, Paul C., Cardon, Zoe G., Chun, Miyoung, Church, George, Dorrestein, Pieter C., Fraser, Scott E., Gilbert, Jack A., Jansson, Janet K., Knight, Rob, Miller, Jeff F., Ozcan, Aydogan, Prather, Kimberly A., Quake, Stephen R., Ruby, Edward G., Silver, Pamela A., Taha, Sharif A., van den Engh, Ger, Weiss, Paul S., Wong, Gerard C. L., Wright, Aaron T., & Young, Thomas D.. Tools for the microbiome. Nano and beyond. United States. doi:10.1021/acsnano.5b07826.
Biteen, Julie S., Blainey, Paul C., Cardon, Zoe G., Chun, Miyoung, Church, George, Dorrestein, Pieter C., Fraser, Scott E., Gilbert, Jack A., Jansson, Janet K., Knight, Rob, Miller, Jeff F., Ozcan, Aydogan, Prather, Kimberly A., Quake, Stephen R., Ruby, Edward G., Silver, Pamela A., Taha, Sharif A., van den Engh, Ger, Weiss, Paul S., Wong, Gerard C. L., Wright, Aaron T., and Young, Thomas D.. 2015.
"Tools for the microbiome. Nano and beyond". United States.
doi:10.1021/acsnano.5b07826.
@article{osti_1233975,
title = {Tools for the microbiome. Nano and beyond},
author = {Biteen, Julie S. and Blainey, Paul C. and Cardon, Zoe G. and Chun, Miyoung and Church, George and Dorrestein, Pieter C. and Fraser, Scott E. and Gilbert, Jack A. and Jansson, Janet K. and Knight, Rob and Miller, Jeff F. and Ozcan, Aydogan and Prather, Kimberly A. and Quake, Stephen R. and Ruby, Edward G. and Silver, Pamela A. and Taha, Sharif A. and van den Engh, Ger and Weiss, Paul S. and Wong, Gerard C. L. and Wright, Aaron T. and Young, Thomas D.},
abstractNote = {Here, the microbiome presents great opportunities for understanding and improving the world around us and elucidating the interactions that compose it. The microbiome also poses tremendous challenges for mapping and manipulating the entangled networks of interactions among myriad diverse organisms. Here, we describe the opportunities, technical needs, and potential approaches to address these challenges, based on recent and upcoming advances in measurement and control at the nanoscale and beyond. Moreover, these technical needs will provide the basis for advancing the largely descriptive studies of the microbiome to the theoretical and mechanistic understandings that will underpin the discipline of microbiome engineering. We anticipate that the new tools and methods developed will also be more broadly useful in environmental monitoring, medicine, forensics, and other areas.},
doi = {10.1021/acsnano.5b07826},
journal = {ACS Nano},
number = 1,
volume = 10,
place = {United States},
year = {2015},
month = {12}
}