Proteomics informed by transcriptomics identifies novel secreted proteins in Dermacentor andersoni saliva

Mudenda, Lwiindi; Pierlé, Sebastián Aguilar; Turse, Joshua E.; Scoles, Glen A.; Purvine, Samuel O.; Nicora, Carrie D.; Clauss, Therese R. W.; Ueti, Massaro W.; Brown, Wendy C.; Brayton, Kelly A.

doi:10.1016/j.ijpara.2014.07.003

Title: Proteomics informed by transcriptomics identifies novel secreted proteins in Dermacentor andersoni saliva

Full Record
Other Related Research

Authors:: Mudenda, Lwiindi; Pierlé, Sebastián Aguilar; Turse, Joshua E.; Scoles, Glen A.; Purvine, Samuel O.; Nicora, Carrie D.; Clauss, Therese R. W.; Ueti, Massaro W.; Brown, Wendy C.; Brayton, Kelly A.

Publication Date:: Sat Nov 01 00:00:00 EDT 2014

Sponsoring Org.:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

OSTI Identifier:: 1227547

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: International Journal for Parasitology

Additional Journal Information:: Journal Name: International Journal for Parasitology Journal Volume: 44 Journal Issue: 13; Journal ID: ISSN 0020-7519

Publisher:: Elsevier

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Mudenda, Lwiindi, Pierlé, Sebastián Aguilar, Turse, Joshua E., Scoles, Glen A., Purvine, Samuel O., Nicora, Carrie D., Clauss, Therese R. W., Ueti, Massaro W., Brown, Wendy C., and Brayton, Kelly A. Proteomics informed by transcriptomics identifies novel secreted proteins in Dermacentor andersoni saliva.  United Kingdom: N. p., 2014. 
Web.  doi:10.1016/j.ijpara.2014.07.003.

Copy to clipboard


                    Mudenda, Lwiindi, Pierlé, Sebastián Aguilar, Turse, Joshua E., Scoles, Glen A., Purvine, Samuel O., Nicora, Carrie D., Clauss, Therese R. W., Ueti, Massaro W., Brown, Wendy C., & Brayton, Kelly A. Proteomics informed by transcriptomics identifies novel secreted proteins in Dermacentor andersoni saliva.  United Kingdom.  https://doi.org/10.1016/j.ijpara.2014.07.003

Copy to clipboard


                    Mudenda, Lwiindi, Pierlé, Sebastián Aguilar, Turse, Joshua E., Scoles, Glen A., Purvine, Samuel O., Nicora, Carrie D., Clauss, Therese R. W., Ueti, Massaro W., Brown, Wendy C., and Brayton, Kelly A. Sat .  
"Proteomics informed by transcriptomics identifies novel secreted proteins in Dermacentor andersoni saliva".  United Kingdom.  https://doi.org/10.1016/j.ijpara.2014.07.003.

Copy to clipboard


                    
@article{osti_1227547,

  title        = {Proteomics informed by transcriptomics identifies novel secreted proteins in Dermacentor andersoni saliva},

  author       = {Mudenda, Lwiindi and Pierlé, Sebastián Aguilar and Turse, Joshua E. and Scoles, Glen A. and Purvine, Samuel O. and Nicora, Carrie D. and Clauss, Therese R. W. and Ueti, Massaro W. and Brown, Wendy C. and Brayton, Kelly A.},

  abstractNote = {},

  doi          = {10.1016/j.ijpara.2014.07.003},

  journal      = {International Journal for Parasitology},

  number       = 13,

  volume       = 44,

  place        = {United Kingdom},

  year         = {Sat Nov 01 00:00:00 EDT 2014},

  month        = {Sat Nov 01 00:00:00 EDT 2014}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1016/j.ijpara.2014.07.003

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 45 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Proteomics informed by transcriptomics identifies novel secreted proteins in Dermacentor andersoni saliva

Journal Article Mudenda, Lwiindi ; Aguilar Pierle, Sebastian ; Turse, Joshua E. ; ... - International Journal for Parasitology, 44(13):1029-1037

Dermacentor andersoni, known as the Rocky Mountain wood tick, is found in the western United States and transmits pathogens that cause diseases of veterinary and public health importance including Rocky Mountain spotted fever, tularemia, Colorado tick fever and bovine anaplasmosis. Tick saliva is known to modulate both innate and acquired immune responses, enabling ticks to feed for several days without detection. During feeding ticks subvert host defences such as hemostasis and inflammation, which would otherwise result in coagulation, wound repair and rejection of the tick. Molecular characterization of the proteins and pharmacological molecules secreted in tick saliva offers an opportunitymore »« less
https://doi.org/10.1016/j.ijpara.2014.07.003
Novel Ser/Thr Protein Phosphatase 5 (PP5) Regulated Targets during DNA Damage Identified by Proteomics Analysis

Journal Article Ham, Bryan M ; Jayachandran, Hemalatha ; Yang, Feng ; ... - Journal of Proteome Research, 9(2):945-953

The DNA damage response is a global phosphorylation signaling cascade process involved in sensing the damaged DNA condition and coordinating responses to cope with and repair the perturbed cellular state. We utilized a label-free liquid chromatography-mass spectrometry approach to evaluate changes in protein phosphorylation associated with PP5 activity during the DNA damage response. Biological replicate analyses of bleomycin-treated HeLa cells expressing either WT-PP5 or mutant inactive PP5 lead to the identification of six potential target proteins of PP5 action. Four of these putative targets are known to be involved in DNA damage responses. Using phospho-site specific antibodies, we confirmed thatmore »« less
https://doi.org/10.1021/pr9008207
Proteomic Analysis of Saliva in HIV-positive Heroin Addicts Reveals Proteins Correlated with Cognition

Journal Article Dominy, Stephen ; Brown, Joseph N. ; Ryder, Mark I. ; ... - PLoS One, 9(4):e89366

The prevalence of HIV-associated neurocognitive disorders (HAND) remains high despite effective antiretroviral therapies. Multiple etiologies have been proposed over the last few years to account for this phenomenon, including the neurotoxic effects of antiretrovirals and co-morbid substance abuse. However, no underlying molecular mechanism has been identified. Emerging evidence in several fields has linked the gut to brain diseases, but the effect of the gut on the brain during HIV infection has not been explored. Saliva is the most accessible gut biofluid, and is therefore of great scientific interest for diagnostic and prognostic purposes. This study presents a longitudinal, liquid chromatography-massmore »« less
https://doi.org/10.1371/journal.pone.0089366
Mapping soil carbon from cradle to grave: using comparative transcriptomics, proteomics and metabolite analysis to identify the microbial blueprint for root-enhanced decomposition of organic matter.

Dataset Firestone, Mary
https://doi.org/10.25585/1487760

View Dataset
Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung

Journal Article Du, Yina ; Clair, Geremy CD ; Alam, Denise A. ; ... - American Journal of Physiology-Lung Cellular and Molecular Physiology

Systems biology uses computational approaches to integrate diverse data types to understand cell and organ behavior. Data derived from complementary technologies, for example transcriptomic and proteomic analyses, are providing new insights into development and disease. We compared mRNA and protein profiles from purified endothelial, epithelial, immune, and mesenchymal cells from normal human lung tissue. Signatures for each cell type were identified and compared at both mRNA and protein levels. Cell specific biological processes and pathways were predicted by analysis of concordant and discordant RNA-protein pairs. Cell clustering and gene set enrichment comparisons identified shared versus unique processes associated with transcriptomicmore »« less
https://doi.org/10.1152/ajplung.00475.2018

Similar Records