Search Menu
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search Scholarly Publications

Title: SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

Authors:
 [1];  [2];  [1];  [2];  [3];  [4];  [4];  [2];  [2];  [2];  [5];  [1];  [1];  [6];  [6];  [6];  [1];  [1];  [7];  [7] more »;  [8];  [3];  [9];  [5];  [10];  [1] « less
+ Show Author Affiliations
  1. Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States
  2. Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington 98109, United States
  3. Department of Chemistry, University of Washington, Seattle, Washington 98195, United States
  4. Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States
  5. Portland VA Medical Center, Portland, Oregon 97239, United States
  6. AbbVie, N. Chicago, Illinois 60064, United States
  7. PATH, San Francisco, California 94102, United States
  8. Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, United States
  9. Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States, Department of Global Health, University of Washington, Seattle, Washington 98195, United States
  10. Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington 98109, United States, Department of Global Health, University of Washington, Seattle, Washington 98195, United States
Publication Date:
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1227228
Grant/Contract Number:  
AC02-76SF00515
Resource Type:
Published Article
Journal Name:
ACS Medicinal Chemistry Letters
Additional Journal Information:
Journal Name: ACS Medicinal Chemistry Letters Journal Volume: 6 Journal Issue: 12; Journal ID: ISSN 1948-5875
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English

Citation Formats

Huang, Wenlin, Ojo, Kayode K., Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Hulverson, Matthew A., Barrett, Lynn K., Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M., Kurnick, Matthew D., Freiberg, Gail M., Kempf, Dale, Hol, Wim G. J., Merritt, Ethan A., Neckermann, Georg, de Hostos, Eugenio L., Isoherranen, Nina, Maly, Dustin J., Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C., and Fan, Erkang. SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. United States: N. p., 2015. Web. doi:10.1021/acsmedchemlett.5b00319.
Copy to clipboard
Huang, Wenlin, Ojo, Kayode K., Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Hulverson, Matthew A., Barrett, Lynn K., Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M., Kurnick, Matthew D., Freiberg, Gail M., Kempf, Dale, Hol, Wim G. J., Merritt, Ethan A., Neckermann, Georg, de Hostos, Eugenio L., Isoherranen, Nina, Maly, Dustin J., Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C., & Fan, Erkang. SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. United States. https://doi.org/10.1021/acsmedchemlett.5b00319
Copy to clipboard
Huang, Wenlin, Ojo, Kayode K., Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Hulverson, Matthew A., Barrett, Lynn K., Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M., Kurnick, Matthew D., Freiberg, Gail M., Kempf, Dale, Hol, Wim G. J., Merritt, Ethan A., Neckermann, Georg, de Hostos, Eugenio L., Isoherranen, Nina, Maly, Dustin J., Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C., and Fan, Erkang. Mon . "SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1". United States. https://doi.org/10.1021/acsmedchemlett.5b00319.
Copy to clipboard
@article{osti_1227228,
title = {SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1},
author = {Huang, Wenlin and Ojo, Kayode K. and Zhang, Zhongsheng and Rivas, Kasey and Vidadala, Rama Subba Rao and Scheele, Suzanne and DeRocher, Amy E. and Choi, Ryan and Hulverson, Matthew A. and Barrett, Lynn K. and Bruzual, Igor and Siddaramaiah, Latha Kallur and Kerchner, Keshia M. and Kurnick, Matthew D. and Freiberg, Gail M. and Kempf, Dale and Hol, Wim G. J. and Merritt, Ethan A. and Neckermann, Georg and de Hostos, Eugenio L. and Isoherranen, Nina and Maly, Dustin J. and Parsons, Marilyn and Doggett, J. Stone and Van Voorhis, Wesley C. and Fan, Erkang},
abstractNote = {},
doi = {10.1021/acsmedchemlett.5b00319},
journal = {ACS Medicinal Chemistry Letters},
number = 12,
volume = 6,
place = {United States},
year = {Mon Oct 26 00:00:00 EDT 2015},
month = {Mon Oct 26 00:00:00 EDT 2015}
}
Copy to clipboard
Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1021/acsmedchemlett.5b00319
Copyright Statement
Other availability
Search WorldCat Search WorldCat to find libraries that may hold this journal
Citation Metrics:
Cited by: 29 works
Citation information provided by
Web of Science
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

Works referenced in this record:

Attachment of Toxoplasma gondii to Host Cells Involves Major Surface Protein, SAG-1 (P-30)
journal, August 1994

Use of the Kinase Inhibitor Analog 1NM-PP1 Reveals a Role for Toxoplasma gondii CDPK1 in the Invasion Step
journal, April 2010

  • Sugi, Tatsuki; Kato, Kentaro; Kobayashi, Kyosuke
  • Eukaryotic Cell, Vol. 9, Issue 4
  • DOI: 10.1128/EC.00351-09

Calcium-Dependent Signaling and Kinases in Apicomplexan Parasites
journal, June 2009

Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol
journal, February 2015

  • Goedken, Eric R.; Argiriadi, Maria A.; Banach, David L.
  • Journal of Biological Chemistry, Vol. 290, Issue 8
  • DOI: 10.1074/jbc.M114.595181

Development and Applications of a Broad-Coverage, TR-FRET-Based Kinase Binding Assay Platform
journal, June 2009

  • Lebakken, Connie S.; Riddle, Steven M.; Singh, Upinder
  • Journal of Biomolecular Screening, Vol. 14, Issue 8
  • DOI: 10.1177/1087057109339207

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium
journal, May 2010

  • Wernimont, Amy K.; Artz, Jennifer D.; Finerty, Patrick
  • Nature Structural & Molecular Biology, Vol. 17, Issue 5
  • DOI: 10.1038/nsmb.1795

Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold
journal, November 2013

  • Zhang, Zhongsheng; Ojo, Kayode K.; Vidadala, RamaSubbaRao
  • ACS Medicinal Chemistry Letters, Vol. 5, Issue 1
  • DOI: 10.1021/ml400315s

Intracellular calcium stores in Toxoplasma gondii govern invasion of host cells
journal, July 2003

  • Lovett, Jennie L.; Sibley, L. David
  • Journal of Cell Science, Vol. 116, Issue 14
  • DOI: 10.1242/jcs.00596

Generation of Monospecific Nanomolar Tyrosine Kinase Inhibitors via a Chemical Genetic Approach
journal, February 1999

  • Bishop, Anthony C.; Kung, Chi-yun; Shah, Kavita
  • Journal of the American Chemical Society, Vol. 121, Issue 4
  • DOI: 10.1021/ja983267v

Apical Organelle Discharge by Cryptosporidium parvum Is Temperature, Cytoskeleton, and Intracellular Calcium Dependent and Required for Host Cell Invasion
journal, December 2004

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii
journal, July 2010

  • Murphy, Ryan C.; Ojo, Kayode K.; Larson, Eric T.
  • ACS Medicinal Chemistry Letters, Vol. 1, Issue 7
  • DOI: 10.1021/ml100096t

Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 ( Tg CDPK1) Inhibitors with Potent Anti- Toxoplasma Activity
journal, February 2012

  • Johnson, Steven M.; Murphy, Ryan C.; Geiger, Jennifer A.
  • Journal of Medicinal Chemistry, Vol. 55, Issue 5
  • DOI: 10.1021/jm201713h

Kinetics of parasite burdens in blood and tissues during murine toxoplasmosis
journal, July 2012

  • Djurković-Djaković, Olgica; Djokić, Vitomir; Vujanić, Marija
  • Experimental Parasitology, Vol. 131, Issue 3
  • DOI: 10.1016/j.exppara.2012.05.006

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
journal, May 2010

  • Lourido, Sebastian; Shuman, Joel; Zhang, Chao
  • Nature, Vol. 465, Issue 7296
  • DOI: 10.1038/nature09022

Optimizing Small Molecule Inhibitors of Calcium-Dependent Protein Kinase 1 to Prevent Infection by Toxoplasma gondii
journal, March 2013

  • Lourido, Sebastian; Zhang, Chao; Lopez, Michael S.
  • Journal of Medicinal Chemistry, Vol. 56, Issue 7
  • DOI: 10.1021/jm4001314

Fragment-Based Cocktail Crystallography by the Medical Structural Genomics of Pathogenic Protozoa Consortium
journal, December 2009

  • Verlinde, Christophe; Fan, Erkang; Shibata, Sayaka
  • Current Topics in Medicinal Chemistry, Vol. 9, Issue 18
  • DOI: 10.2174/156802609790102383

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1
journal, August 2012

  • Zhang, Zhongsheng; Ojo, Kayode K.; Johnson, Steven M.
  • Bioorganic & Medicinal Chemistry Letters, Vol. 22, Issue 16
  • DOI: 10.1016/j.bmcl.2012.06.050

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors
journal, May 2010

  • Ojo, Kayode K.; Larson, Eric T.; Keyloun, Katelyn R.
  • Nature Structural & Molecular Biology, Vol. 17, Issue 5
  • DOI: 10.1038/nsmb.1818

A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases
journal, May 2005

  • Zhang, Chao; Kenski, Denise M.; Paulson, Jennifer L.
  • Nature Methods, Vol. 2, Issue 6
  • DOI: 10.1038/nmeth764

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1
journal, March 2012

  • Larson, Eric T.; Ojo, Kayode K.; Murphy, Ryan C.
  • Journal of Medicinal Chemistry, Vol. 55, Issue 6
  • DOI: 10.1021/jm201725v

Toxoplasmosis
book, January 2011

    Sort by:
    [ × clear filter / sort ]

    Similar Records in DOE PAGES and OSTI.GOV collections: