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Title: SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

Authors:
 [1] ;  [2] ;  [1] ;  [2] ;  [3] ;  [4] ;  [4] ;  [2] ;  [2] ;  [2] ;  [5] ;  [1] ;  [1] ;  [6] ;  [6] ;  [6] ;  [1] ;  [1] ;  [7] ;  [7] more »;  [8] ;  [3] ;  [9] ;  [5] ;  [10] ;  [1] « less
  1. Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States
  2. Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington 98109, United States
  3. Department of Chemistry, University of Washington, Seattle, Washington 98195, United States
  4. Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States
  5. Portland VA Medical Center, Portland, Oregon 97239, United States
  6. AbbVie, N. Chicago, Illinois 60064, United States
  7. PATH, San Francisco, California 94102, United States
  8. Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, United States
  9. Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States, Department of Global Health, University of Washington, Seattle, Washington 98195, United States
  10. Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington 98109, United States, Department of Global Health, University of Washington, Seattle, Washington 98195, United States
Publication Date:
Grant/Contract Number:
AC02-76SF00515
Type:
Published Article
Journal Name:
ACS Medicinal Chemistry Letters
Additional Journal Information:
Journal Volume: 6; Journal Issue: 12; Related Information: CHORUS Timestamp: 2017-12-11 09:52:00; Journal ID: ISSN 1948-5875
Publisher:
American Chemical Society
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
OSTI Identifier:
1227228