skip to main content

DOE PAGESDOE PAGES

Title: Phase-contrast Hounsfield units of fixated and non-fixated soft-tissue samples

X-ray phase-contrast imaging is a novel technology that achieves high soft-tissue contrast. Although its clinical impact is still under investigation, the technique may potentially improve clinical diagnostics. In conventional attenuation-based X-ray computed tomography, radiological diagnostics are quantified by Hounsfield units. Corresponding Hounsfield units for phase-contrast imaging have been recently introduced, enabling a setup-independent comparison and standardized interpretation of imaging results. Thus far, the experimental values of few tissue types have been reported; these values have been determined from fixated tissue samples. This study presents phase-contrast Hounsfield units for various types of non-fixated human soft tissues. A large variety of tissue specimens ranging from adipose, muscle and connective tissues to liver, kidney and pancreas tissues were imaged by a grating interferometer with a rotating-anode X-ray tube and a photon-counting detector. In addition, we investigated the effects of formalin fixation on the quantitative phase-contrast imaging results.
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [2] ;  [3] ;  [3] ;  [3] ;  [1] ;  [1] ;  [4]
  1. Technische Univ. Munchen, Garching (Germany)
  2. Ludwig-Maximilians-Univ., Munchen (Germany)
  3. Technische Univ. Munchen, Munich (Germany)
  4. Argonne National Lab. (ANL), Argonne, IL (United States)
Publication Date:
Grant/Contract Number:
AC02-06CH11357
Type:
Accepted Manuscript
Journal Name:
PLoS ONE
Additional Journal Information:
Journal Volume: 10; Journal Issue: 8; Journal ID: ISSN 1932-6203
Publisher:
Public Library of Science
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; formaldehyde; muscle tissue; X-ray radiography; electron density; adipose tissue; computed axial tomography; formalin fixation; kidneys
OSTI Identifier:
1223866

Willner, Marian, Fior, Gabriel, Marschner, Mathias, Birnbacher, Lorenz, Schock, Jonathan, Braun, Christian, Fingerle, Alexander A., Noël, Peter B., Rummeny, Ernst J., Pfeiffer, Franz, Herzen, Julia, and Rozhkova, Elena A.. Phase-contrast Hounsfield units of fixated and non-fixated soft-tissue samples. United States: N. p., Web. doi:10.1371/journal.pone.0137016.
Willner, Marian, Fior, Gabriel, Marschner, Mathias, Birnbacher, Lorenz, Schock, Jonathan, Braun, Christian, Fingerle, Alexander A., Noël, Peter B., Rummeny, Ernst J., Pfeiffer, Franz, Herzen, Julia, & Rozhkova, Elena A.. Phase-contrast Hounsfield units of fixated and non-fixated soft-tissue samples. United States. doi:10.1371/journal.pone.0137016.
Willner, Marian, Fior, Gabriel, Marschner, Mathias, Birnbacher, Lorenz, Schock, Jonathan, Braun, Christian, Fingerle, Alexander A., Noël, Peter B., Rummeny, Ernst J., Pfeiffer, Franz, Herzen, Julia, and Rozhkova, Elena A.. 2015. "Phase-contrast Hounsfield units of fixated and non-fixated soft-tissue samples". United States. doi:10.1371/journal.pone.0137016. https://www.osti.gov/servlets/purl/1223866.
@article{osti_1223866,
title = {Phase-contrast Hounsfield units of fixated and non-fixated soft-tissue samples},
author = {Willner, Marian and Fior, Gabriel and Marschner, Mathias and Birnbacher, Lorenz and Schock, Jonathan and Braun, Christian and Fingerle, Alexander A. and Noël, Peter B. and Rummeny, Ernst J. and Pfeiffer, Franz and Herzen, Julia and Rozhkova, Elena A.},
abstractNote = {X-ray phase-contrast imaging is a novel technology that achieves high soft-tissue contrast. Although its clinical impact is still under investigation, the technique may potentially improve clinical diagnostics. In conventional attenuation-based X-ray computed tomography, radiological diagnostics are quantified by Hounsfield units. Corresponding Hounsfield units for phase-contrast imaging have been recently introduced, enabling a setup-independent comparison and standardized interpretation of imaging results. Thus far, the experimental values of few tissue types have been reported; these values have been determined from fixated tissue samples. This study presents phase-contrast Hounsfield units for various types of non-fixated human soft tissues. A large variety of tissue specimens ranging from adipose, muscle and connective tissues to liver, kidney and pancreas tissues were imaged by a grating interferometer with a rotating-anode X-ray tube and a photon-counting detector. In addition, we investigated the effects of formalin fixation on the quantitative phase-contrast imaging results.},
doi = {10.1371/journal.pone.0137016},
journal = {PLoS ONE},
number = 8,
volume = 10,
place = {United States},
year = {2015},
month = {8}
}