Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling
Abstract
Defects in the ability to respond properly to an unrepaired DNA lesion blocking replication promote genomic instability and cancer. Human HLTF, implicated in error-free replication of damaged DNA and tumour suppression, exhibits a HIRAN domain, a RING domain, and a SWI/SNF domain facilitating DNA-binding, PCNA-polyubiquitin-ligase, and dsDNA-translocase activities, respectively. Here, we investigate the mechanism of HLTF action with emphasis on its HIRAN domain. We found that in cells HLTF promotes the filling-in of gaps left opposite damaged DNA during replication, and this postreplication repair function depends on its HIRAN domain. Our biochemical assays show that HIRAN domain mutant HLTF proteins retain their ubiquitin ligase, ATPase and dsDNA translocase activities but are impaired in binding to a model replication fork. These data and our structural study indicate that the HIRAN domain recruits HLTF to a stalled replication fork, and it also provides the direction for the movement of the dsDNA translocase motor domain for fork reversal. We suggest functional similarities between the HIRAN, the OB, the HARP2, and other domains found in certain motor proteins, which may explain why only a subset of DNA translocases can carry out fork reversal.
- Authors:
-
- Hungarian Academy of Sciences, Szeged (Hungary)
- Zhejiang Univ., Hangzhou (China)
- Dana Farber Cancer Institute, Boston, MA (United States)
- Vilnius Univ., Vilnius (Lithuania)
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1223716
- Grant/Contract Number:
- AC02-06CH11357
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nucleic Acids Research
- Additional Journal Information:
- Journal Name: Nucleic Acids Research; Journal ID: ISSN 0305-1048
- Publisher:
- Oxford University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Achar, Yathish Jagadheesh, Balogh, David, Neculai, Dante, Juhasz, Szilvia, Morocz, Monika, Gali, Himabindu, Dhe-Paganon, Sirano, Venclovas, Česlovas, and Haracska, Lajos. Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling. United States: N. p., 2015.
Web. doi:10.1093/nar/gkv896.
Achar, Yathish Jagadheesh, Balogh, David, Neculai, Dante, Juhasz, Szilvia, Morocz, Monika, Gali, Himabindu, Dhe-Paganon, Sirano, Venclovas, Česlovas, & Haracska, Lajos. Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling. United States. https://doi.org/10.1093/nar/gkv896
Achar, Yathish Jagadheesh, Balogh, David, Neculai, Dante, Juhasz, Szilvia, Morocz, Monika, Gali, Himabindu, Dhe-Paganon, Sirano, Venclovas, Česlovas, and Haracska, Lajos. Tue .
"Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling". United States. https://doi.org/10.1093/nar/gkv896. https://www.osti.gov/servlets/purl/1223716.
@article{osti_1223716,
title = {Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling},
author = {Achar, Yathish Jagadheesh and Balogh, David and Neculai, Dante and Juhasz, Szilvia and Morocz, Monika and Gali, Himabindu and Dhe-Paganon, Sirano and Venclovas, Česlovas and Haracska, Lajos},
abstractNote = {Defects in the ability to respond properly to an unrepaired DNA lesion blocking replication promote genomic instability and cancer. Human HLTF, implicated in error-free replication of damaged DNA and tumour suppression, exhibits a HIRAN domain, a RING domain, and a SWI/SNF domain facilitating DNA-binding, PCNA-polyubiquitin-ligase, and dsDNA-translocase activities, respectively. Here, we investigate the mechanism of HLTF action with emphasis on its HIRAN domain. We found that in cells HLTF promotes the filling-in of gaps left opposite damaged DNA during replication, and this postreplication repair function depends on its HIRAN domain. Our biochemical assays show that HIRAN domain mutant HLTF proteins retain their ubiquitin ligase, ATPase and dsDNA translocase activities but are impaired in binding to a model replication fork. These data and our structural study indicate that the HIRAN domain recruits HLTF to a stalled replication fork, and it also provides the direction for the movement of the dsDNA translocase motor domain for fork reversal. We suggest functional similarities between the HIRAN, the OB, the HARP2, and other domains found in certain motor proteins, which may explain why only a subset of DNA translocases can carry out fork reversal.},
doi = {10.1093/nar/gkv896},
journal = {Nucleic Acids Research},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 08 00:00:00 EDT 2015},
month = {Tue Sep 08 00:00:00 EDT 2015}
}
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